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ADC Cytotoxin

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ADC Cytotoxin are a large collection of toxins for antibody-drug conjugate (ADC) development projects. The toxins that can be used as payloads should be soluble, amenable to conjugation, and stable. There are myriads of cellular toxins in natural or synthesized, but only a few have been found adaptable for an ADC concept.

The toxins targeting tubulin filaments include Maytansinoids, Auristatins, Taxol derivatives, etc. Amatoxins are a class of transcription-inhibiting agents. They bind to RNA polymerase II, leading to cell apoptosis. Protein toxins function in the similar MOA (mechanism of action) with cellular toxins, they could inhibit protein synthesis and induce cell death. While enzyme-based ADCs alter the microenvironment of disease tissues to disturb their functions.

Products Related to ADC Cytotoxin(111)

  • GC73858 structure
    GC73858Glucocorticoid receptor agonist-4
    CAS: 2842165-72-2
    Purity: >99.00%

    Glucocorticoid receptor agonist-4 (화합물제제5)는 TNF-α 항체와 결합하여 자가면역 및 염증성 질환 연구에 사용할 수 있는 당피질 호르몬 수용체 흥분제입니다.

  • GC73938 structure
    GC73938PBD-monoamide
    CAS: 2093165-00-3
    Purity: >96.00%

    PBD-monoamide 수식된 PBD(피프로닐디옥사이드) 이중합체는 ADC 세포독소의 일종이다.

  • GC74118 structure
    GC74118SJG-136 intermediate-1
    CAS: 232931-64-5
    Purity: >99.00%

    SJG-136 intermediate-1(화합물 19)는 SJG-136을 합성하는 중간체다.

  • GC74122 structure
    GC74122Taltobulin intermediate-4
    CAS: 187345-37-5
    Purity: >99.00%

    Taltobulin intermediate-4 는 Taltobulin 합성의 중간체입니다.

  • GC74127 structure
    GC74127(R)-Exatecan Intermediate 1
    CAS: 110351-91-2
    Purity: >99.00%

    (R)-Exatecan Intermediate 1는 엑사테칸 중간체 1의 이성질체입니다.

  • GC74132 structure
    GC74132Exatecan Intermediate 5
    CAS: 143655-70-3
    Purity: >99.00%

    Exatecan Intermediate 5 는 Exatecan의 중간체이며 Exatecan (DX-8951) 은 암 연구에 사용할 수있는 IC50 수치가 2.2 μM (0.975 μg/mL) 인 DNA 토폴로지아제 I 억제제입니다.

  • GC74134 structure
    GC74134Exatecan Intermediate 6
    CAS: 143655-58-7
    Purity: >98.00%

    Exatecan Intermediate 6 는 Exatecan의 중간체이며 Exatecan (DX-8951) 은 암 연구에 사용할 수있는 IC50 수치가 2.2 μM (0.975 μg/mL) 인 DNA 토폴로지아제 I 억제제입니다.

  • GC74135 structure
    GC74135Exatecan Intermediate 7
    CAS: 182182-32-7
    Purity: >99.00%

    Exatecan Intermediate 7 는 Exatecan의 중간체이며 Exatecan (DX-8951) 은 암 연구에 사용할 수있는 IC50 수치가 2.2 μM (0.975 μg/mL) 인 DNA 토폴로지아제 I 억제제입니다.

  • GC74147 structure
    GC74147TAM558 intermediate-5
    CAS: 1415659-15-2
    Purity: >95.00%

    TAM558 intermediate-5는 TAM558 합성에서 중간체입니다.

  • GC74150 structure
    GC74150Exatecan analog 36
    Purity: >98.00%

    Exatecan analog 36 는 Exatecan의 유사 물질입니다.

  • GC74178 structure
    GC74178Ac-Exatecan
    CAS: 2922852-48-8
    Purity: >98.00%

    Ac-Exatecan아세틸화 된 Exatecan입니다.

  • GC74652 structure
    GC74652Exatecan Intermediate 2 hydrochloride
    CAS: 2437603-23-9
    Purity: >99.00%

    Exatecan Intermediate 2 hydrochloride (화합물 B) 는 Exatecan (DX-8951) 의 중간체입니다.

  • GC74653 structure
    GC74653Exatecan Intermediate 4
    CAS: 2436720-50-0

    Exatecan Intermediate 4 (화합물 B)는 엑사테탄 (DX-8951,)의 중간체이다.

  • GC74654 structure
    GC74654Exatecan Intermediate 4 dihydrochloride
    Purity: >99.00%

    Exatecan Intermediate 4 dihydrochloride은 Exatecan(DX-8951)의 중간체입니다.

  • GN10449 structure
    GN10449SN-38 (NK012)
    CAS: 86639-52-3
    Purity: >99.50%