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Lipoxygenase

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Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.

Products Related to Lipoxygenase(264)

  • GC41220 structure
    GC4122013(S)-HODE methyl ester
    CAS: 109837-85-6
    Purity: >98.00%

    13(S)-hydroxyoctadecadienoic acid (13(S)-HODE) is a 15-lipoxygenase metabolite of linoleic acid produced in endothelial cells, leukocytes, and tumor cells.

  • GC41227 structure
    GC4122717(R)-Resolvin D1 methyl ester
    CAS: 937738-64-2
    Purity: >95.00%

    17(R)-Resolvin D1 (17(R)-RvD1) is an aspirin-triggered epimer of RvD1 that reduces human polymorphonuclear leukocyte transendothelial migration, the earliest event in acute inflammation, with equipotency to RvD1 (EC50 = ~30 nM).

  • GC41230 structure
    GC41230Resolvin D1 methyl ester
    CAS: 937738-63-1
    Purity: >97.00%

    Resolvin D1 메틸 에스테르(RvD1 메틸 에스테르)는 Resolvin D1의 메틸 에스테르입니다.

  • GC41231 structure
    GC41231Resolvin D2 methyl ester
    CAS: 810668-53-2
    Purity: >95.00%

    Resolvin D2 (RvD2) is a lipid mediator biosynthesized by the sequential oxygenation of docosahexaenoic acid by 15- and 5-lipoxygenase.

  • GC41232 structure
    GC41232Resolvin D3 methyl ester
    Purity: >95.00%

    Resolvin D3 methyl ester is a methyl ester version of the free acid that may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties.

  • GC41289 structure
    GC41289U-75302
    CAS: 119477-85-9
    Purity: >95.00%

    U-75302는 류코트리엔 B4의 강력한 억제제입니다.

  • GC41322 structure
    GC413225-OxoETE methyl ester
    CAS: 74785-00-5
    Purity: >95.00%

    5-OxoETE methyl ester is an esterified form of the polyunsaturated keto acid 5-oxoETE.

  • GC41403 structure
    GC4140315(S)-HpEDE
    CAS: 145375-41-3
    Purity: >98.00%

    15(S)-HpEDE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 15-lipoxygenase on eicosadienoic acid.

  • GC41415 structure
    GC4141515(R)-Lipoxin A4
    CAS: 171030-11-8
    Purity: >95.00%

    Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function.

  • GC41421 structure
    GC4142120-hydroxy Leukotriene B4
    CAS: 79516-82-8
    Purity: >97.00%

    20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils.

  • GC41424 structure
    GC414246(S)-Lipoxin A4
    CAS: 94292-80-5
    Purity: >95.00%

    The lipoxins are trihydroxy fatty acids containing a 7,9,11,13-conjugated tetraene.

  • GC41529 structure
    GC4152917-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
    CAS: 1233715-28-0
    Purity: >90.00%

    17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity.

  • GC41531 structure
    GC41531Anacardic Acid Triene
    CAS: 103904-73-0
    Purity: >98.00%

    Anacardic acid triene is a polyunsaturated form of anacardic acid that has been found in cashew nut shell liquid.

  • GC41649 structure
    GC41649(±)13-HODE cholesteryl ester
    CAS: 167354-91-8
    Purity: >98.00%

    (±)13-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL.

  • GC41666 structure
    GC41666(±)9-HODE cholesteryl ester
    CAS: 33783-76-5
    Purity: >98.00%

    (±)9-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL.

  • GC41770 structure
    GC417701,2,3-Trieicosapentaenoyl-rac-glycerol
    CAS: 99660-94-3
    Purity: >98%

    1,2,3-Trieicosapentaenoyl-rac-glycerol (EPA-TG) is a glycerol ester of eicosapentaenoic acid, which is an ω-3 fatty acid.

  • GC41882 structure
    GC4188212(S)-HETrE
    CAS: 72710-10-2
    Purity: >98.00%

    12(S)-HETrE is produced by 12-lipoxygenase oxidation of dihomo-γ-linolenic acid (DGLA).

  • GC41896 structure
    GC4189613(S)-HODE-biotin
    CAS: 1176496-97-1
    Purity: >98.00%

    13(S)-HODE is the lipoxygenase metabolite of linoleic acid.

  • GC41897 structure
    GC4189713(S)-HOTrE
    CAS: 87984-82-5
    Purity: >98.00%

    13(S)-HOTrE is the 15-lipoxygenase (15-LO) product of linolenic acid.

  • GC41898 structure
    GC4189813(S)-HOTrE(γ)
    CAS: 74784-20-6
    Purity: >98.00%

    13(S)-HOTrE(γ) is the 15-LO product of γ-linolenic acid.

  • GC41899 structure
    GC4189913(S)-HpOTrE
    CAS: 67597-26-6
    Purity: >98.00%

    13(S)-HpOTrE is a monohydroperoxy polyunsaturated fatty acid produced in soybeans by the action of soybean LO-2 on esterified α-linolenic acid.

  • GC41900 structure
    GC4190013(S)-HpOTrE(γ)
    CAS: 121107-97-9
    Purity: >98.00%

    13(S)-HpOTrE(γ) is a monohydroxy PUFA produced by the action of soybean lipoxygenase-1 (LO-1) on γ-linolenic acid.

  • GC41911 structure
    GC4191113-epi-12-oxo Phytodienoic Acid
    CAS: 71606-07-0
    Purity: >95.00%

    13-epi-12-oxo Phytodienoic acid (13-epi-12-oxo PDA) is a lipoxygenase metabolite of α-linolenic acid in the leaves of green plants such as corn.

  • GC41925 structure
    GC4192515(S)-HETE Ethanolamide
    CAS: 161744-53-2
    Purity: >98.00%

    Arachidonoyl ethanolamide was the first endogenous cannabinoid (CB) to be isolated and characterized as an agonist acting on the same receptors (CB1 and CB2) as THC.