Lipoxygenase
Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.
Targets for Lipoxygenase
Products for Lipoxygenase
- Cat.No. 상품명 정보
- GC38000 β-Boswellic acid β-Boswellic acid는 Boswellia serrate의 고무 수지에서 분리됩니다.ޚ-Boswellic acid는 5-lipoxygenase(5-LO) 생성물 형성을 직접 차단하거나 상호작용하는 전위를 차단하는 비환원형 억제제입니다. . β - 보스웰산은 인간 백혈병 HL-60 세포에서 DNA, RNA 및 단백질 합성을 억제합니다.
- GC41649 (±)13-HODE cholesteryl ester (±)13-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL.
- GC40828 (±)5-HETE lactone (±)5-HETE lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of (±)5-HETE.
- GC41666 (±)9-HODE cholesteryl ester (±)9-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL.
- GC41770 1,2,3-Trieicosapentaenoyl-rac-glycerol 1,2,3-Trieicosapentaenoyl-rac-glycerol (EPA-TG) is a glycerol ester of eicosapentaenoic acid, which is an ω-3 fatty acid.
- GC45948 1,2,3-Trilinoelaidoyl-rac-glycerol A triacylglycerol
- GC42039 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position.
- GC42040 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position.
- GC49730 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11 An internal standard for the quantification of 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE
- GC42041 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position.
- GC42042 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position.
- GC40971 10(S),17(S)-DiHDHA 10(S),17(S)-DiHDHA(신경 조직에서 생성될 때 뉴로프로텍틴 D1이라고도 함)는 DHA에서 파생된 디하이드록시 지방산으로 강력한 보호 및 항염 활성을 나타냅니다.
- GC40368 11(R)-HEPE 11(R)-HEPE is produced by the oxidation of EPA by 11(R)-LO.
- GC40445 11(R)-HETE 11(R)-HETE is biosynthesized by 11(R)-LOs of the sea urchin, S.
- GC10821 11-keto-β-Boswellic Acid 11-Keto-beta-boswellic acid(11-Keto-β-boswellic acid)는 인도 유향으로 널리 알려진 Boswellia serrate tree의 껍질에서 추출한 올레오검 수지의 5환형 트리테르펜산입니다. 11-Keto-beta-boswellic acid는 주로 5-lipoxygenase(5-LOX) 및 후속 류코트리엔 및 핵 인자-카파 B(NF-κB) 활성화 및 종양 괴사 인자 알파 생성을 억제하기 때문에 항염증 활성이 있습니다. 생산.
- GC41144 11-trans Leukotriene C4 11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4.
- GC41147 11-trans Leukotriene D4 11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4.
- GC41149 11-trans Leukotriene E4 11-trans 류코트리엔 E4는 류코트리엔 E4(LTE4)의 이성질체입니다.
- GC40447 12(R)-HETE Biosynthesis of 12(R)-HETE in invertebrates is via lipoxygenation of arachidonic acid.
- GC40371 12(S)-HEPE 12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO.
-
GC40448
12(S)-HETE
12(S)-HETE is the predominant lipoxygenase product of mammalian platelets.
- GC41882 12(S)-HETrE 12(S)-HETrE is produced by 12-lipoxygenase oxidation of dihomo-γ-linolenic acid (DGLA).
-
GC41095
12(S)-HpEPE
12(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 12-lipoxygenase on eicosapentaenoic acid.
- GC41122 12(S)-HpETE 12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid.
- GC41123 12-epi Leukotriene B4 Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes.
- GC41096 12-oxo Leukotriene B4 Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway.
- GC46418 12-oxo-13-HOME An oxylipin
- GC40372 12-OxoETE 12-OxoETE is synthesized by human platelets and Aplysia nervous tissue after incubation with arachidonic acid.
- GC19462 13(R)-HODE 13(R)-HODE is the opposite enantiomer of the 13(S)-HODE produced when linoleic acid is incubated with soybean lipoxygenase.
- GC19463 13(S)-HODE 리놀레산의 15-리폭시게나제(15-LOX) 대사 산물인 13(S)-HODE(13(S)-HODE)는 PPARγ을 활성화하는 내인성 리간드로 기능합니다.
- GC41220 13(S)-HODE methyl ester 13(S)-hydroxyoctadecadienoic acid (13(S)-HODE) is a 15-lipoxygenase metabolite of linoleic acid produced in endothelial cells, leukocytes, and tumor cells.
- GC41896 13(S)-HODE-biotin 13(S)-HODE is the lipoxygenase metabolite of linoleic acid.
- GC46420 13(S)-HODE-d4 An internal standard for the quantification of 13-HODE
- GC41897 13(S)-HOTrE 13(S)-HOTrE is the 15-lipoxygenase (15-LO) product of linolenic acid.
- GC41898 13(S)-HOTrE(γ) 13(S)-HOTrE(γ) is the 15-LO product of γ-linolenic acid.
- GC19474 13(S)-HpODE 13(S)-HpODE is produced by the oxidation of linoleic acid by lipoxygenase-1 (LO-1) in many plants including soybean, flaxseed, apples, and tea leaves,1,2 and by 15-LO in mammals.
-
GC41899
13(S)-HpOTrE
13(S)-HpOTrE is a monohydroperoxy polyunsaturated fatty acid produced in soybeans by the action of soybean LO-2 on esterified α-linolenic acid.
- GC41900 13(S)-HpOTrE(γ) 13(S)-HpOTrE(γ) is a monohydroxy PUFA produced by the action of soybean lipoxygenase-1 (LO-1) on γ-linolenic acid.
- GC41911 13-epi-12-oxo Phytodienoic Acid 13-epi-12-oxo Phytodienoic acid (13-epi-12-oxo PDA) is a lipoxygenase metabolite of α-linolenic acid in the leaves of green plants such as corn.
- GC41206 14(S)-HDHA 14(S)-HDHA(14(S)-HDoHE)는 도코사헥사엔산(DHA)의 산소화 생성물입니다.
- GC41100 14,15-dehydro Leukotriene B4 Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway.
- GC41145 14,15-Leukotriene C4 Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes.
- GC41148 14,15-Leukotriene D4 14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates.
- GC41150 14,15-Leukotriene E4 Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes.
-
GC41415
15(R)-Lipoxin A4
Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function.
- GC40427 15(S)-HEDE 15(S)-HEDE is produced from 11Z,14Z-eicosadienoic acid by 15-LO.
- GC40373 15(S)-HEPE 15(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 15-LO.
- GC40451 15(S)-HETE 15(S)-HETE is a major arachidonic acid metabolite from the 15-lipoxygenase pathway.
- GC41925 15(S)-HETE Ethanolamide Arachidonoyl ethanolamide was the first endogenous cannabinoid (CB) to be isolated and characterized as an agonist acting on the same receptors (CB1 and CB2) as THC.
- GC40839 15(S)-HETE methyl ester 15(S)-HETE methyl ester is a synthetic derivative of 15(S)-HETE, a major arachidonic acid metabolite from the 15-lipoxygenase pathway.
- GC46442 15(S)-HETE-d8 An internal standard for the quantification of 15-HETE
- GC49894 15(S)-HETE-d8 ethyl ester An internal standard for the quantification of 15(S)-HETE ethyl ester
- GC41927 15(S)-HETrE 15(S)-HETrE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of dihomo-γ-linolenic acid.
-
GC41403
15(S)-HpEDE
15(S)-HpEDE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 15-lipoxygenase on eicosadienoic acid.
-
GC41101
15(S)-HpEPE
15(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 15-lipoxygenase on eicosapentaenoic acid.
-
GC41124
15(S)-HpETE
15(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid.
- GC41938 15-Lipoxygenase Inhibitor 1 15-리폭시게나제 억제제 1은 IC50이 18 μ인 15-리폭시게나제의 선택적 억제제입니다. 15-리폭시게나제 억제제 1은 IC50이 각각 19.5 μM 및 19.1 μM입니다. 대두 15-리폭시게나제(SLO) 및 인간 15-리폭시게나제-1(15)-LOX-1(15)- 15-Lipoxygenase Inhibitor 1은 전립선암 연구에 잠재력이 있습니다.
- GC41940 15-OxoEDE 15-OxoEDE is produced by the oxidation of 15-HEDE.
- GC40376 15-OxoETE 15-OxoETE is produced by oxidation of the 15-hydroxyl of 15-HETE.
-
GC41951
17(R)-Resolvin D1
Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.
- GC41227 17(R)-Resolvin D1 methyl ester 17(R)-Resolvin D1 (17(R)-RvD1) is an aspirin-triggered epimer of RvD1 that reduces human polymorphonuclear leukocyte transendothelial migration, the earliest event in acute inflammation, with equipotency to RvD1 (EC50 = ~30 nM).
- GC41952 17(R)-Resolvin D4 17(R)-Resolvin D4 (17(R)-RvD4) is an aspirin-triggered epimer of RvD4 .
- GC41208 17(S)-HDHA 17(S)-HDHA is a primary mono-oxygenation product of docosahexaenoic acid in human whole blood, human leukocytes, and mouse brain.
- GC49356 17(S)-HDoTE A metabolite of adrenic acid
- GC40975 17(S)-HpDHA 17(S)-HpDHA is a mono-oxygenation product of docosahexaenoic acid in human whole blood, human leukocytes, human glial cells, and mouse brain.
- GC41529 17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid 17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity.
- GC41209 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid Docosapentaenoic acid (DPA) is a ω-3 fatty acid found in fish oils.
- GC41980 18-carboxy dinor Leukotriene B4 18-carboxy dinor Leukotriene B4 (18-carboxy dinor LTB4) is a β-oxidation metabolite of LTB4.
- GC46057 2,5-Dihydroxycinnamic Acid phenethyl ester An inhibitor of 5-LO
- GC42082 20-carboxy Leukotriene B4 20-carboxy LTB4 is a metabolite of LTB4 in human neutrophils.
- GC41421 20-hydroxy Leukotriene B4 20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils.
- GC49849 3-Aminosalicylic Acid A salicylic acid derivative
- GC49364 3-Hydroxycoumarin 3-하이드록시쿠마린은 인간 15-LOX-1의 강력한 산화환원 억제제입니다.
- GC64078 3-O-Acetyl-11-hydroxy-beta-boswellic acid 3-O-아세틸-11-하이드록시-베타-보스웰산은 강력한 5-리폭시게나제(5-LO) 억제제입니다.
- GC30277 4',5-Dihydroxyflavone 4',5-디하이드록시플라본은 대두 LOX-1 및 효모 α-글루코시다아제 억제제로서 대두 LOX-1의 Ki는 102.6μM이고 효모 α-글루코시다아제의 IC50은 66μM입니다.
- GC64621 4-Nitrocatechol 4-Nitrocatechol은 강력한 리폭시게나제 억제제입니다.
- GC40459 5(R)-HETE 5(R)-HETE is a rare lipoxygenase product of arachidonic acid.
- GC41126 5(S),12(S)-DiHETE 5(S),12(S)-DiHETE is a natural bioactive lipid derived from arachidonic acid.
- GC41127 5(S),15(S)-DiHETE 5(S),15(S)-DiHETE는 \5(S),15(S)-DiHETE is an “activated” intermediate, inhibits platelet aggregation with an IC50 of 1.3 μM.en_ko_2021q1.md
- GC41128 5(S),6(R)-11-trans DiHETE 5(S),6(R)-11-trans DiHETE is a C-11 double bond isomer of 5(S),6(R)-DiHETE that is formed by the enzymatic isomerization of 5(S),6(R)-DiHETE by a membrane bound factor.
- GC41129 5(S),6(R)-DiHETE 5(S),6(R)-DiHETE is a dihydroxy polyunsaturated fatty acid and a nonenzymatic hydrolysis product of leukotriene A4 (LTA4).
- GC41131 5(S),6(S)-DiHETE 5(S),6(S)-DiHETE is one of the four diastereomeric 5,6-dihydroxy acids produced from the non-enzymatic hydrolysis of LTA4.
- GC40378 5(S)-HEPE 5(S)-HEPE is produced by 5-lipoxygenase catalyzed oxidation of eicosapentaenoic acid (EPA).
- GC40460 5(S)-HETE 5(S)-HETE is produced by the action of 5-LO on arachidonic acid to give 5(S)-HpETE, followed by reduction of the hydroperoxide.
- GC40829 5(S)-HETE lactone 5(S)-HETE lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of 5(S)-HETE.
- GC46679 5(S)-HETE-d8 An internal standard for the quantification of 5-HETE
- GC42479 5(S)-HETrE 5(S)-HETrE is produced by the action of 5-LO when mead acid is the substrate.
- GC41105 5(S)-HpEPE 5(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 5-LO on EPA.
- GC40784 5(Z),8(Z),14(Z)-Eicosatrienoic Acid 5(Z),8(Z),14(Z)-Eicosatrienoic acid is a polyunsaturated fatty acid that can be a substrate for 5-lipoxygenase (5-LO).
- GC40830 5,6-dehydro Arachidonic Acid 5,6-dehydro Arachidonic acid is an analog of arachidonic acid with an acetylene in the 5,6 position.
- GC52413 5-Aminosalicylic Acid-d7 An internal standard for the quantification of 5-aminosalicylic acid
- GC31997 5-Lipoxygenase-In-1 5-리폭시게나제-In-1은 특허 EP 331232 A2, 표 4, 화합물 실시예 4.10에서 추출한 5-리폭시게나제 억제제입니다.
- GC66031 5-LOX-IN-1 5-LOX-IN-1(화합물 2b)은 IC50 값이 2.3 μ인 인간 5-Lipoxygenase(5-LOX)의 억제제입니다. 821d96072c2d58d8970e76f526b0f6b85-LOX-IN-1은 염증 연구에 사용할 수 있습니다.821d96072c2d58d8970e76f526b0f6b8
- GC35168 5-O-Demethylnobiletin 5-O-Demethylnobiletin(5-Demethylnobiletin)은 Sideritis tragoriganum에서 분리된 폴리메톡시플라본으로 COX-2의 발현에 영향을 미치지 않으면서 5-LOX(IC50=0.1μM)를 직접적으로 억제합니다.
-
GC40380
5-OxoETE
5-OxoETE is a polyunsaturated keto acid formed by the oxidation of 5-HETE in human neutrophils by a specific dehydrogenase.
- GC41322 5-OxoETE methyl ester 5-OxoETE methyl ester is an esterified form of the polyunsaturated keto acid 5-oxoETE.
- GC41424 6(S)-Lipoxin A4 The lipoxins are trihydroxy fatty acids containing a 7,9,11,13-conjugated tetraene.
- GC46732 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid A metabolite of DPA with antiinflammatory properties
- GC40978 7-epi Maresin 1 7-epi Maresin 1 is the inactive 7(S) epimer of Maresin 1, which contains a 7(R) hydroxyl group.
- GC40462 8(R)-HETE 8(R)-HETE is biosynthesized by lipoxygenation of arachidonic acid in marine invertebrates such as gorgonian corals and starfish.