GLPBio

Schizandrin B

Catalog No.: GN10132Purity:>98.00%Synonyms: Wuweizisu B
COASDSData Sheet
Schizandrin B is a kind of natural compounds which isolated from Schisandra chinensis, possesses a variety of pharmacokinetic properties, including antioxidant, anti-inflammatory, cardiacprotection and neuroprotection.

제품은 연구용으로만 사용됩니다. 인체에 사용할 수 없으며 환자에게 판매하지 않습니다.

Schizandrin B
Cas No.: 61281-37-6
10mM (in 1mL DMSO)In Stock
$22.00
1
5mgIn Stock
$20.00
1
10mgIn Stock
$30.00
1
25mgIn Stock
$63.00
1
50mgIn Stock
$100.00
1
100mgIn Stock
$140.00
1
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인용 문헌 (Citations)

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    Cell
    183(7):1867-1883 (2020)
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제품 설명 (Description)

Schizandrin B is a kind of natural compounds which isolated from Schisandra chinensis, possesses a variety of pharmacokinetic properties, including antioxidant, anti-inflammatory, cardiacprotection and neuroprotection [1]. Schizandrin B is a natural nonenzymatic antioxidant with low toxicity and low cost and has a broad application prospect oxidation inhibitor and it could be used in the cure of many diseases [1].

Schizandrin B (20μM; 18h) reversed the hypoxia/reoxygenation-induced upregulation of IL-6 and IL-8 in H9c2 cells [2]. Schizandrin B (20μM; 2h) significantly alleviated the reduction in HK‑2 cell viability induced by cis‑dichlorodiammine platinum (DDP) [3]. Schizandrin B (1, 5, 25, 50, 100, 150 and 200μM; 24h) inhibited the growth of RAW 264.7 cells in a concentration-dependent manner [4].

Schizandrin B (50mg/kg; 2 weeks; i.g.) suppressed the level of blood glucose of C57BL/KSJ db/db mice; Schizandrin B (50mg/kg; 2 weeks; i.g.) significantly decreased the relative liver weight of C57BL/KSJ db/db mice [5]. Schizandrin B (20, 40mg/kg; 8 weeks; i.g.) decreased the serum markers of cellular damage, lactate dehydrogenase (LDH) and creatine kinase-cardiac (CK-MB) in diabetic (db/db) mice[6].

References:
[1] Nasser M I, Zhu S, Chen C, et al. A Comprehensive Review on Schisandrin B and Its Biological Properties [J]. Oxidative medicine and cellular longevity, 2020, 2020: 2172740.
[2] Zhao B, Li G P, Peng J J, et al. Schizandrin B attenuates hypoxia/reoxygenation injury in H9c2 cells by activating the AMPK/Nrf2 signaling pathway [J]. Experimental and therapeutic medicine, 2021, 21(3): 220.
[3] Liu Q, Song J, Li H, et al. Schizandrin B inhibits the cis‑DDP‑induced apoptosis of HK‑2 cells by activating ERK/NF‑κB signaling to regulate the expression of survivin [J]. International journal of molecular medicine, 2018, 41(4): 2108-2016.
[4] Zhang Y, Zhou Z W, Jin H, et al. Schisandrin B inhibits cell growth and induces cellular apoptosis and autophagy in mouse hepatocytes and macrophages: implications for its hepatotoxicity [J]. Drug design, development and therapy, 2015, 9: 2001-2027.
[5] Ma R, Zhan Y, Zhang Y, et al. Schisandrin B ameliorates non-alcoholic liver disease through anti-inflammation activation in diabetic mice [J]. Drug development research, 2022, 83(3): 735-744.
[6] Luo W, Lin K, Hua J, et al. Schisandrin B attenuates diabetic cardiomyopathy by targeting MyD88 and inhibiting MyD88-dependent inflammation [J]. Advanced science, 2022, 9(31): e2202590.

실험 프로토콜 (Protocol)

Cell experiment [1]:

Cell lines

H9c2 cells

Preparation Method

The cells were cultured with serum-free medium in an anaerobic chamber containing 1% O2, 5% CO2 and 94% N2 at 37˚C for 6h and then the cells were cultured with normoxic medium in the presence of 95% air and 5% CO2 at 37˚C for 12h in a humidified atmosphere to induce hypoxia/reoxygenation(H/R) injury. Schizandrin B (20μM) was added to the cells prior to H (6h)/R (12h) injury.

Reaction Conditions

20μM; 18h

Applications

Schizandrin B significantly increased cell viability compared with H/R treatment.
Animal experiment [2]:

Animal models

C57BL/KSJ db/db mice

Preparation Method

Mice whose blood glucose levels greater than 11mmol/L were considered as diabetic mice. Schizandrin B was dissolved with DMSO (DMSO final concentration < 0.5%), and each mouse was administrated 0.2ml solution. The control group was given an equal volume of DMSO solution. Blood glucose was recorded after drug treatment of 2-week. Blood samples adopted from the tail of mice were monitored using a commercial glucose monitoring system.

Dosage form

50mg/kg; 2 weeks; i.g.

Applications

Schizandrin B suppressed the level of blood glucose.

References:
[1] Zhao B, Li G P, Peng J J, et al. Schizandrin B attenuates hypoxia/reoxygenation injury in H9c2 cells by activating the AMPK/Nrf2 signaling pathway [J]. Experimental and therapeutic medicine, 2021, 21(3): 220.
[2] Ma R, Zhan Y, Zhang Y, et al. Schisandrin B ameliorates non-alcoholic liver disease through anti-inflammation activation in diabetic mice [J]. Drug development research, 2022, 83(3): 735-744.

제품 문서 (Product Documents)

Purity:>98.00%Appearance:A solid
COASDSData Sheet

화학적 특성 (Chemical Properties)

CAS 번호
61281-37-6
동의어
Wuweizisu B
화학명
1,2,3,13-tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxole
SMILES
[H]C(C([H])([H])C(C1=C2OC([H])([H])[H])=C([H])C3=C2OC([H])([H])O3)(C([H])([H])[H])C(C([H])([H])[H])([H])C([H])([H])C(C1=C4OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C4OC([H])([H])[H]
분자식
C23H28O6
분자량
400.46
용해도
≥ 20mg/mL in DMSO
보관
Store at 2-8°C, protect from light
일반 주의사항
제품의 용해도 데이터에 따라 적절한 용매를 선택하십시오. 조제 후에는 반복적인 동결·해동을 피할 수 있도록 저장 용액을 소분하십시오.
저장 용액은 -80°C 보관 시 6개월 이내, -20°C 보관 시 1개월 이내에 사용하십시오.
용해도를 높이려면 튜브를 37°C로 데운 뒤 적절한 시간 동안 초음파 처리하십시오.
배송 조건
평가용 샘플은 아이스팩과 함께 배송됩니다. 그 외 용량은 실온 배송되며, 요청 시 아이스팩과 함께 배송할 수 있습니다.

계산 도구 (Calculators)몰 농도 / 희석 / 분자량 / 단위 변환 / 생체 내 제형 / 용해도

g/mol

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