SR 7826 |
| Catalog No.GC50219 |
SR 7826은 LIMK1에 대해 IC50이 43nM인 강력한 선택적 경구 활성 LIMK(LIM kinase) 억제제 계열의 비스-아릴 요소 유래입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1219728-20-7
Sample solution is provided at 25 µL, 10mM.
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Potent and selective LIMK inhibitor (IC50 values are 43, 5536 and 6565 nM for LIMK1, ROCKI and ROCKII, respectively). Inhibits cofilin phosphorylation in A7r5 cells and suppresses migration and invasion of PC-3 cells in vitro. Orally bioavailable.
Yin et al (2015) Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors. J.Med.Chem. 58 1846 PMID:25621531
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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