Potent and selective LIMK inhibitor (IC50 values are 43, 5536 and 6565 nM for LIMK1, ROCKI and ROCKII, respectively). Inhibits cofilin phosphorylation in A7r5 cells and suppresses migration and invasion of PC-3 cells in vitro. Orally bioavailable.
Yin et al (2015) Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors. J.Med.Chem. 58 1846 PMID:25621531