FTI-2153 |
| Catalog No.GC60861 |
FTI-2153은 IC50이 1.4nM인 강력하고 고도로 선택적인 파르네실트랜스퍼라제(FTase) 억제제입니다. FTI-2153은 Rap1A 처리보다 H-Ras(IC50, 10nM)를 차단하는 데 3000배 이상 강력합니다. 항암 활성.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 344900-92-1
Sample solution is provided at 25 µL, 10mM.
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FTI-2153 is a potent and highly selective inhibitor of farnesyltransferase (FTase), with an IC50 of 1.4 nM. FTI-2153 is >3000-fold more potent at blocking H-Ras (IC50, 10 nM) than Rap1A processing. Anti-cancer activity[1].
[1]. Sun J, et al. Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine. Cancer Res. 1999 Oct 1;59(19):4919-26.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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