GLPBio

ULK

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ULK1, a serine/threonine protein kinase, is an enzyme that in humans is encoded by the ULK1 gene. ULK1 is essential for the initial stages of autophagy. ULK1 is an important protein in autophagy. It is part of the ULK1-complex, which is needed in early steps of autophagosome biogenesis. ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation.

ULK2 is essential for astrocyte transformation and tumor growth. ULK2 also inhibits the growth of glioma cells, which requires autophagy induction as kinase mutant of ULK2 fails to induce autophagy and inhibit growth. ULK2 and its homologue ULK1 are only down-regulated in all grades of glioma. Thus these results altogether suggest that inhibition of autophagy by ULK1/2 down-regulation is essential for glioma development.

Products Related to ULK(13)

  • GC14086 structure
    GC14086MRT68921
    CAS: 1190379-70-4
    Purity: >98%

    MRT68921은 ULK1과 ULK2의 강력한 이중 억제제로서 각각의 IC50 값은 2.9nM 및 1.1nM이다.

  • GC15654 structure
    GC15654SBI-0206965
    CAS: 1884220-36-3
    Purity: >99.00%

    SBI - 0206965 피리미딘 유도체는 IC 50 값이 108nM인 고도로 선택적인 키나제 ULK1 저해제이다.

  • GC17136 structure
    GC17136MRT67307
    CAS: 1190378-57-4
    Purity: >98.50%

    A kinase inhibitor

  • GC19236 structure
    GC19236LYN-1604
    CAS: 2088939-99-3
    Purity: >98%

    LYN-1604는 삼중 음성 유방암(TNBC) 연구를 위한 강력한 UNC-51 유사 키나제 1(ULK1) 활성제(EC50=18.94 nM)입니다.

  • GC34315 structure
    GC34315ULK-101
    CAS: 2443816-45-1
    Purity: >99.50%

    ULK-101은 선택적 ULK1 억제제(IC 50 =1.6nM)로 ULK2 활성도 억제한다(IC 50 =30nM).

  • GC36517 structure
    GC36517LYN-1604 hydrochloride
    CAS: 2216753-86-3
    Purity: >98%

    LYN-1604 염산염은 삼중 음성 유방암(TNBC) 연구를 위한 강력한 UNC-51 유사 키나제 1(ULK1) 활성제(EC50=18.94 nM)입니다.

  • GC36654 structure
    GC36654MRT68921 dihydrochloride
    CAS: 2080306-21-2
    Purity: >99.50%

    MRT68921 디히드로클로라이드는 ULK1 및 ULK2의 강력한 억제제이며 IC50 값은 각각 2.9nM 및 1.1nM입니다.

  • GC60891 structure
    GC60891GW406108X
    CAS: 1644443-92-4
    Purity: >98.00%

    GW406108X는 ATPase 분석에서 IC50이 0.82μM인 특정 Kif15(Kinesin-12) 억제제입니다. 강력한 자가포식 억제제인 GW406108X는 6.37(427nM)의 pIC50으로 ULK1에 대한 ATP 경쟁적 억제를 보여줍니다. GW406108X는 업스트림 신호 전달 키나제 mTORC1 및 AMPK에 영향을 미치지 않으면서 ULK1 키나제 활성을 억제하고 자가포식 플럭스를 차단합니다.

  • GC62146 structure
    GC62146XST-14
    CAS: 2607143-50-8
    Purity: >99.50%

    XST-14는 IC50이 26.6nM인 강력하고 경쟁적이며 고도로 선택적인 ULK1 억제제입니다. XST-14는 ULK1 다운스트림 기질의 인산화를 감소시켜 자가포식 억제를 유도합니다. XST-14는 간세포 암종(HCC) 세포에서 세포자멸사를 유도하고 항종양 효과가 있습니다.

  • GC73892 structure
    GC73892DCC-3116
    CAS: 2543673-19-2
    Purity: >99.00%

    DCC-3116 는 경구 활성 ULK1/2 억제제의 일종이다.

  • GC78994 structure
    GC78994SBP-1750
    CAS: 1884219-70-8
    Purity: >98.00%

    SBP-1750 is an orally active ULK inhibitor and an ATG13 degrader.

  • GC81304 structure
    GC81304GW296115
    CAS: 118458-58-5
    Purity: >98.50%

    GW296115 is a multi-target inhibitor with the following IC 50 values against its targets: 8.4 nM for BRSK2, 21 nM for BRSK1, 1.8 μM for PDGFRβ, 5.5 nM for STK17B/DRAK2, 28 nM for DRAK1, 20 nM for PHKG1, and 89 nM for DCAMKL3.

  • GC81673 structure
    GC81673UE01
    CAS: 486440-74-8
    Purity: >98%

    UE01 is an orally active, selective small-molecule modulator targeting both ULK1/ERK1/2.