KT-474 hydrochloride (Synonyms: KYM-001 hydrochloride; PROTAC IRAK4 degrader-7 hydrochloride) |
Catalog No.GC80943
One-Click Copy Product Info
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KT-474 (KYM-001; PROTAC IRAK4 degrader-7) hydrochloride is an orally active PROTAC IRAK4 degrader with anti-tumor effects.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2751703-31-6
Sample solution is provided at 25 µL, 10mM.
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References:
[1]. Nello Mainolfi, et al. Irak degraders and uses thereof. Patent WO2020113233A1.
[2]. Ackerman L, et al. IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial. Nat Med. 2023 Dec;29(12):3127-3136.
[3]. Joseph F. Kelleher, et al. Abstract LB-272: KYM-001, a first-in-class oral IRAK4 protein degrader, induces tumor regression in xenograft models of MYD88-mutant ABC DLBCL alone and in combination with BTK inhibition. Cancer Res (2019) 79 (13_Supplement): LB-272.
| Cas No. | 2751703-31-6 | SDF | |
| Synonyms | KYM-001 hydrochloride; PROTAC IRAK4 degrader-7 hydrochloride | ||
| Formula | C44H50ClF2N11O6 | M.Wt | 902.39 |
| Solubility | DMSO: 55 mg/mL (60.95 mM; Need ultrasonic) | Storage | Store at room temperature, keep dry and cool |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.1082 mL | 5.5408 mL | 11.0817 mL |
| 5 mM | 221.6 μL | 1.1082 mL | 2.2163 mL |
| 10 mM | 110.8 μL | 554.1 μL | 1.1082 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)