GLPBio

MARK4 inhibitor 2

Catalog No.: GC73537Purity:>99.00%
COASDSData Sheet
MARK4 inhibitor 2 is an inhibitor of microtubule affinity-regulating kinase 4 (MARK4) with an Km of 6.3×10 7 and an IC50 of 0.82 μM.

Products are for research use only. Not for human use. We do not sell to patients.

MARK4 inhibitor 2
1 mgIn Stock
$140.00
1
5 mgIn Stock
$351.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

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    187(9):2288-2304 (2024)
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Description

MARK4 inhibitor 2 is an inhibitor of microtubule affinity-regulating kinase 4 (MARK4) with an Km of 6.3×10 7 and an IC50 of 0.82 μM. MARK4 inhibitor 2 inhibits the growth of human cells and can be used for cancer research.

MARK4 inhibitor 2 (Compound 23a) (0-20 μM; 24 hour) inhibits the growth of HeLa, U87MG, MDA-MB-435, U251 and HGFs cells with EC50s ranging from 1.76 μM to 7.98 μM[1].

References:
[1]. Maria Voura, et.al. Synthesis, Structural Modification, and Bioactivity Evaluation of Substituted Acridones as Potent Microtubule Affinity-Regulating Kinase 4 InhibitorsACS Pharmacology & Translational Science 2023 6 (7), 1052-1074.

Product Documents

Purity:>99.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

Molecular Formula
C34H30N4O3
Molecular Weight
542.63
Solubility
DMSO : 100 mg/mL (184.29 mM; Need ultrasonic)
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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