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Home >> Signaling Pathways >> PI3K/Akt/mTOR Signaling >> AMPK

AMPK

AMPK (5'AMP-activated protein kinase) acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of GLUT4 (glucose transporter 4) and mitochondria.

Products for  AMPK

  1. Cat.No. Product Name Information
  2. GC35124 3α-Hydroxymogrol 3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle, acts as a potent AMPK activator, and enhances AMPK phosphorylation. 3α-Hydroxymogrol Chemical Structure
  3. GC13992 3-Guanidinopropionic Acid RGX-202 (3-Guanidinopropionic acid) is an oral small-molecule SLC6A8 transporter inhibitor. RGX-202 robustly inhibits creatine import in vitro and in vivo, reduces intracellular phosphocreatine and ATP levels, and induces tumor apoptosis. RGX-202 can be used for the research of cancer and duchenne muscular dystrophy. 3-Guanidinopropionic Acid Chemical Structure
  4. GN10093 6-gingerol 6-gingerol Chemical Structure
  5. GC31348 7-Methoxyisoflavone A synthetic isoflavone 7-Methoxyisoflavone Chemical Structure
  6. GC11234 A-769662 A direct activator of AMPK A-769662 Chemical Structure
  7. GC10518 AICAR

    An activator of AMPK

     AICAR Chemical Structure
  8. GC10580 AICAR phosphate AMPK activator AICAR phosphate Chemical Structure
  9. GC66024 Aldometanib Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib can activate lysosomal adenosine monophosphate-activated protein kinase (AMPK) and decreases blood glucose. Aldometanib can be used for the research of metabolic homeostasis. Aldometanib Chemical Structure
  10. GC42776 Amarogentin

    A secoiridoid glycoside with diverse biological activities

     Amarogentin Chemical Structure
  11. GC11190 AMPK activator AMPK activator is a cell penetrant AMPK activator and partially inhibits the mitochondrial complex I. In multiple myeloma cells, AMPK activator inhibits cell growth. AMPK activator Chemical Structure
  12. GC35327 AMPK activator 1 AMPK activator 1 is an AMPK activator extracted from patent WO2013116491A1, compound No.1-75, has an EC50 of <0.1μM. AMPK activator 1 Chemical Structure
  13. GC62841 AMPK activator 4 AMPK activator 4 is a potent AMPK activator without inhibition of mitochondrial complex I. AMPK activator 4 Chemical Structure
  14. GC67961 AMPK-IN-3 AMPK-IN-3 Chemical Structure
  15. GC16534 Ampkinone AMPK activator Ampkinone Chemical Structure
  16. GC67772 BAY-3827 BAY-3827 Chemical Structure
  17. GC62135 BC1618 BC1618, an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling (via preventing activated pAmpkα from Fbxo48-mediated degradation). BC1618 Chemical Structure
  18. GC42987 Buformin (hydrochloride) Buformin is a biguanide derivative with antihyperglycemic activity. Buformin (hydrochloride) Chemical Structure
  19. GC31383 Chitosan oligosaccharide COS Chitosan oligosaccharide COS Chemical Structure
  20. GN10222 Cimigenol-3-O-α-L-arabinoside Cimigenol-3-O-α-L-arabinoside Chemical Structure
  21. GC62548 COH-SR4 COH-SR4 is an AMPK activator. COH-SR4 Chemical Structure
  22. GC30056 Danthron (Dantron) Danthron (Dantron) is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron (Dantron) functions in regulating glucose and lipid metabolism by activating AMPK. Danthron (Dantron) Chemical Structure
  23. GC38101 Demethyleneberberine

    Demethyleneberberine (DMB), as a natural active component of medicinal plant Cortex phellodendri chinensis, has favorable bioactivity.

     Demethyleneberberine Chemical Structure
  24. GC17243 Dorsomorphin (Compound C) Dorsomorphin (Compound C) (Compound C) is a selective and ATP-competitive AMPK inhibitor (Ki=109 nM in the absence of AMP). Dorsomorphin (Compound C) (BML-275) selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin (Compound C) induces autophagy. Dorsomorphin (Compound C) Chemical Structure
  25. GC12560 Dorsomorphin (Compound C) 2HCl Dorsomorphin (Compound C) 2HCl (BML-275 dihydrochloride; Compound C dihydrochloride) is a potent, selective and ATP-competitive AMPK inhibitor, with a Ki of 109 nM. Dorsomorphin (Compound C) 2HCl inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin (Compound C) 2HCl induces autophagy. Dorsomorphin (Compound C) 2HCl Chemical Structure
  26. GC17567 Doxorubicin (Adriamycin) HCl Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin (Adriamycin) HCl Chemical Structure
  27. GC39377 EB-3D EB-3D is a potent and selective choline kinase α (ChoKα) inhibitor, with an IC50 of 1 μM for ChoKα1. EB-3D exerts effects on ChoKα expression, AMPK activation, apoptosis, endoplasmic reticulum stress and lipid metabolism. EB-3D exhibits a potent antiproliferative activity in a panel of T-leukemia cell lines. Anti-cancer activity. EB-3D Chemical Structure
  28. GC38422 Euphorbiasteroid A tricyclic diterpene Euphorbiasteroid Chemical Structure
  29. GC31411 EX229 A potent and allosteric activator of AMPK EX229 Chemical Structure
  30. GC13466 Flufenamic acid

    TRPC activator

     Flufenamic acid Chemical Structure
  31. GC61855 Galegine hydrochloride

    Galegine hydrochloride, a guanidine derivative, contributes to weight loss in mice.

     Galegine hydrochloride Chemical Structure
  32. GN10473 Ginkgolide C Ginkgolide C Chemical Structure
  33. GC36178 Gomisin J A lignan with diverse biological activities Gomisin J Chemical Structure
  34. GC11724 GSK621 AMPK agonist GSK621 Chemical Structure
  35. GC13696 GSK690693

    GSK690693 is an ATP-competitive, low nanomolar inhibitor of Akt kinases with IC50 values of 2, 13, and 9 nM for Akt1, 2, and 3, respectively.

     GSK690693 Chemical Structure
  36. GC13185 HTH-01-015 NUAK1 inhibitor,highly specific and selective HTH-01-015 Chemical Structure
  37. GC10576 Imeglimin

    Antidiabetic agent

     Imeglimin Chemical Structure
  38. GC10956 Imeglimin hydrochloride Antidiabetic agent Imeglimin hydrochloride Chemical Structure
  39. GC38209 Kahweol A natural diterpene with antiinflammatory and antiangiogenic properties Kahweol Chemical Structure
  40. GC63934 Karanjin Karanjin is a major active furanoflavonol constituent of Fordia cauliflora. Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Karanjin can induce cancer cell death through cell cycle arrest and enhance apoptosis. Karanjin Chemical Structure
  41. GC61029 Marein A glucoside chalcone with diverse biological activities Marein Chemical Structure
  42. GC61045 Metformin D6 hydrochloride An internal standard for the quantification of metformin Metformin D6 hydrochloride Chemical Structure
  43. GC17443 Metformin HCl Metformin HCl (1,1-Dimethylbiguanide hydrochloride) inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin HCl Chemical Structure
  44. GC38815 Methyl cinnamate Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate Chemical Structure
  45. GC31361 MK-3903 MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator with an EC50 of 8 nM. MK-3903 Chemical Structure
  46. GC31470 MK8722 MK8722 is a potent and systemic pan-AMPK activator. MK8722 Chemical Structure
  47. GC25648 MOTS-c MOTS-c, a mitochondria-derived peptide (MDP), exerts antinociceptive and anti-inflammatory effects through activating AMPK pathway and inhibiting MAP kinases-c-fos signaling pathway. MOTS-c Chemical Structure
  48. GC60258 MT 63-78 MT 63-78 is a specific and potent direct AMPK activator with an EC50 of 25 μM. MT 63–78 also induces cell mitotic arrest and apoptosis. MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. MT 63-78 has antitumor effects. MT 63-78 Chemical Structure
  49. GC38567 Nepodin A naphthol with diverse biological activities Nepodin Chemical Structure
  50. GC19269 O-304 O-304 is a small molecule AMPK activator. O-304 Chemical Structure
  51. GC33765 Palmitelaidic Acid (9-trans-Hexadecenoic acid) Palmitelaidic Acid (9-trans-Hexadecenoic acid) (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitelaidic Acid (9-trans-Hexadecenoic acid) Chemical Structure
  52. GC19286 PF-06409577 PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC50 of 7 nM. PF-06409577 Chemical Structure
  53. GC66002 PF-06685249 PF-06685249 (PF-249) is a potent and orally active allosteric AMPK activator with an EC50 of 12 nM for recombinant AMPK α1β1γ1. PF-06685249 can be used for diabetic nephropathy research. PF-06685249 Chemical Structure
  54. GC10461 Phenformin HCl Phenformin HCl is an anti-diabetic drug from the biguanide class, can activate AMPK activity. Phenformin HCl Chemical Structure
  55. GN10592 Platycodin D Platycodin D Chemical Structure
  56. GC17204 PT 1 AMPK activator, selective PT 1 Chemical Structure
  57. GC12324 RSVA 405 AMPK activator RSVA 405 Chemical Structure
  58. GC12364 SAMS Peptide SAMS Peptide peptide is a specific substrate for the AMP-activated protein kinase (AMPK). SAMS Peptide Chemical Structure
  59. GC37694 STO-609 A CaMKK inhibitor STO-609 Chemical Structure
  60. GC38679 Urolithin B A metabolite of ellagic acid Urolithin B Chemical Structure
  61. GC16549 WZ4003 NUAK1/2 inhibitor, potent and selective WZ4003 Chemical Structure
  62. GC61382 Xanthoangelol Xanthoangelol, extracted from Angelica keiskei, suppresses obesity-induced inflammatory responses. Xanthoangelol Chemical Structure
  63. GC18208 YLF-466D YLF-466D is an orally bioavailable activator of AMP-activated protein kinase (AMPK), an enzyme involved in regulation of cellular energy homeostasis. YLF-466D Chemical Structure
  64. GC37970 ZLN024 An allosteric activator of AMPK ZLN024 Chemical Structure
  65. GC12162 ZLN024 hydrochloride

    novel AMPK allosteric activator

     ZLN024 hydrochloride Chemical Structure

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