Nicotinic Receptor
Nicotinic acetylcholine receptors is a family of ligand-gated ion channels that plays a significant role in the synaptic signaling and involved in neurological diseases, such as Alzheimer’s, Parkinson’s and schizophrenia etc.
Products Related to Nicotinic Receptor(62)
- GC10329Mecamylamine hydrochlorideCAS: 826-39-1Purity: >98.00%
Mecamylamine hydrochloride is a non-selective, non-competitive nicotinic acetylcholine receptor (nAChR) antagonist that can block various nAChR subtypes, such as α3β4, α4β2, and α3β2 receptors, with IC 50 values of 640nM, 2.5μM, and 3.6μM respectively.
- GC10368α-Conotoxin PnIACAS: 705300-84-1Purity: >98%
α-Conotoxin PnIA, a potent and selective antagonist of the mammalian α7 nAChR, has the potential for the research of neurological conditions such as neuropathic pain and Alzheimer's disease.
- GC10872α-Conotoxin AuIBCAS: 216299-21-7Purity: >98%
Selective antagonist of α3β4 nicotinic acetylcholine receptors
- GC10913GTS 21 dihydrochlorideCAS: 156223-05-1Purity: >99.50%
GTS 21 dihydrochloride is a selective partial agonist of the α7 nicotinic acetylcholine receptor (α7-nAChR), possessing anti-inflammatory and cognition-enhancing activities.
- GC10980RJR 2429 dihydrochlorideCAS: 1021418-53-0Purity: >98%
nAChR agonist that displays selectivity for α4β2
- GC11091EVP-6124 hydrochlorideCAS: 550999-74-1Purity: >98.50%
A partial agonist of α7 subunit-containing nAChRs
- GC11406TMPH hydrochlorideCAS: 849461-91-2Purity: >98%
neuronal nicotinic ACh receptors (nAChRs) antagonist
- GC116265-Iodo-A-85380 dihydrochlorideCAS: 1217837-17-6Purity: >98%
α4β2 and α6β2 nicotinic acetylcholine receptors agonist
- GC12432(+)-Anabasine hydrochlorideCAS: 53912-89-3Purity: >98.50%
neuronal nicotinic ACh receptor partial agonist
- GC12593Desformylflustrabromine hydrochlorideCAS: 951322-11-5Purity: >99.50%
Positive allosteric modulator of nicotinic α4β2 receptors
- GC12678PHA 568487CAS: 527680-56-4Purity: >98%
PHA 568487 is a selective alpha 7 nicotinic acetylcholine receptor (α-7 nAchR) agonist.
- GC12952PNU 282987CAS: 123464-89-1Purity: >99.50%
PNU 282987 is a selective α7 nicotinic acetylcholine receptor (α7nAChR) agonist associated with an anti-inflammatory pathway as well as an antagonist of the 5-HT3 receptor, the EC50 of PNU 282987 for α7nAChR is 154nM (K i α7nAChR=27nM, rat brain homogenates) while IC50 for 5-HT3 receptor is 4541nM (K i 5-HT3R=1662nM, GR-65630).
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC12762 | Varenicline | 249296-44-4 | >98.00% | |
α4β2 nAChRs antagonist | ||||
| GC16143 | Varenicline Hydrochloride | 230615-23-3 | >98.50% | |
α4β2 nicotinic receptor agonist | ||||
| GC10009 | Benzoquinonium dibromide | 311-09-1 | >98% | |
inhibitor of AChR and ganglion | ||||
| GC10329 | Mecamylamine hydrochloride | 826-39-1 | >98.00% | |
Mecamylamine hydrochloride is a non-selective, non-competitive nicotinic acetylcholine receptor (nAChR) antagonist that can block various nAChR subtypes, such as α3β4, α4β2, and α3β2 receptors, with IC 50 values of 640nM, 2.5μM, and 3.6μM respectively. | ||||
| GC10368 | α-Conotoxin PnIA | 705300-84-1 | >98% | |
α-Conotoxin PnIA, a potent and selective antagonist of the mammalian α7 nAChR, has the potential for the research of neurological conditions such as neuropathic pain and Alzheimer's disease. | ||||
| GC10484 | 3-pyr-Cytisine | 948027-43-8 | >98% | |
α4β2 receptors agonist | ||||
| GC10575 | RJR-2403 hemioxalate | - | >98% | |
Neuronal nicotinic receptor agonist | ||||
| GC10872 | α-Conotoxin AuIB | 216299-21-7 | >98% | |
Selective antagonist of α3β4 nicotinic acetylcholine receptors | ||||
| GC10913 | GTS 21 dihydrochloride | 156223-05-1 | >99.50% | |
GTS 21 dihydrochloride is a selective partial agonist of the α7 nicotinic acetylcholine receptor (α7-nAChR), possessing anti-inflammatory and cognition-enhancing activities. | ||||
| GC10980 | RJR 2429 dihydrochloride | 1021418-53-0 | >98% | |
nAChR agonist that displays selectivity for α4β2 | ||||
| GC11060 | AR-R 17779 hydrochloride | 178419-42-6 | >98% | |
Selective agonist of α7 nAChRs | ||||
| GC11091 | EVP-6124 hydrochloride | 550999-74-1 | >98.50% | |
A partial agonist of α7 subunit-containing nAChRs | ||||
| GC11406 | TMPH hydrochloride | 849461-91-2 | >98% | |
neuronal nicotinic ACh receptors (nAChRs) antagonist | ||||
| GC11626 | 5-Iodo-A-85380 dihydrochloride | 1217837-17-6 | >98% | |
α4β2 and α6β2 nicotinic acetylcholine receptors agonist | ||||
| GC11757 | 3-Bromocytisine | 207390-14-5 | >98% | |
α4β4, α4β2 and α7 nACh receptor agonist | ||||
| GC12102 | RJR-2403 oxalate | 220662-95-3 | >98% | |
| GC12119 | CCMI | 917837-54-8 | >99.50% | |
Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR) | ||||
| GC12237 | SIB 1508Y maleate | 192231-16-6 | >98% | |
neuronal nicotinic ACh receptor agonist | ||||
| GC12432 | (+)-Anabasine hydrochloride | 53912-89-3 | >98.50% | |
neuronal nicotinic ACh receptor partial agonist | ||||
| GC12593 | Desformylflustrabromine hydrochloride | 951322-11-5 | >99.50% | |
Positive allosteric modulator of nicotinic α4β2 receptors | ||||
| GC12678 | PHA 568487 | 527680-56-4 | >98% | |
PHA 568487 is a selective alpha 7 nicotinic acetylcholine receptor (α-7 nAchR) agonist. | ||||
| GC12770 | LY 2087101 | 913186-74-0 | >98% | |
Allosteric potentiator of α7, α4β2 and α4β4 nAChRs | ||||
| GC12774 | (±)-Anatoxin A fumarate | 1219922-30-1 | >95.00% | |
nicotinic agonist | ||||
| GC12952 | PNU 282987 | 123464-89-1 | >99.50% | |
PNU 282987 is a selective α7 nicotinic acetylcholine receptor (α7nAChR) agonist associated with an anti-inflammatory pathway as well as an antagonist of the 5-HT3 receptor, the EC50 of PNU 282987 for α7nAChR is 154nM (K i α7nAChR=27nM, rat brain homogenates) while IC50 for 5-HT3 receptor is 4541nM (K i 5-HT3R=1662nM, GR-65630). | ||||