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CCMI Catalog No.GC12119

Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR)

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10mg
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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 917837-54-8 SDF
Chemical Name (Z)-N-(4-chlorophenyl)-3-((4-chlorophenyl)amino)-2-(3-methylisoxazol-5-yl)acrylamide
Canonical SMILES ClC1=CC=C(C=C1)NC(/C(C2=CC(C)=NO2)=C\NC(C=C3)=CC=C3Cl)=O
Formula C19H15Cl2N3O2 M.Wt 388.25
Solubility <38.83mg/ml in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

CCMI is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs. CCMI has potential in CNS diseases with cognitive dysfunction[1].

CCMI (Compound 6) is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs[1].

References:
[1]. Ng HJ, et al. Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. Proc Natl Acad Sci U S A. 2007 May 8;104(19):8059-64. Epub 2007 Apr 30.