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CCMI (Synonyms: AVL-3288; UCI-4083)

Catalog No.GC12119

Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR)

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CCMI Chemical Structure

Cas No.: 917837-54-8

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Sample solution is provided at 25 µL, 10mM.

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Background

CCMI is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs. CCMI has potential in CNS diseases with cognitive dysfunction[1].

CCMI (Compound 6) is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs[1].

References:
[1]. Ng HJ, et al. Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. Proc Natl Acad Sci U S A. 2007 May 8;104(19):8059-64. Epub 2007 Apr 30.

Chemical Properties

Cas No. 917837-54-8 SDF
Synonyms AVL-3288; UCI-4083
Chemical Name (Z)-N-(4-chlorophenyl)-3-((4-chlorophenyl)amino)-2-(3-methylisoxazol-5-yl)acrylamide
Canonical SMILES ClC1=CC=C(C=C1)NC(/C(C2=CC(C)=NO2)=C\NC(C=C3)=CC=C3Cl)=O
Formula C19H15Cl2N3O2 M.Wt 388.25
Solubility <38.83mg/ml in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.5757 mL 12.8783 mL 25.7566 mL
5 mM 0.5151 mL 2.5757 mL 5.1513 mL
10 mM 0.2576 mL 1.2878 mL 2.5757 mL
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Reviews

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Average Rating: 5 ★★★★★ (Based on Reviews and 40 reference(s) in Google Scholar.)

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