Palitantin is a fungal metabolite originally isolated from P. palitans. It inhibits HIV-1 integrase with IC50 values of 350 and 268 uM for 3'-processing and strand transfer activity, respectively. Palitantin has been used as a standard for dereplication of natural products.
Citations
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Chemical Properties
CAS No.
15265-28-8
Synonyms
NSC 246119, (±)-Palitantin
Chemical Name
(2R,3S,5R,6R)-rel-3-(1E,3E)-1,3-heptadien-1-yl-5,6-dihydroxy-2-(hydroxymethyl)-cyclohexanone
SMILES
O=C1[C@H](O)[C@H](O)C[C@@H](/C=C/C=C/CCC)[C@@H]1CO
Molecular Formula
C14H22O4
Molecular Weight
254.3
Solubility
Soluble in DMSO
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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