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Penitrem A Catalog No.GC11608

BKCa (KCa1.1) channels blocker

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 12627-35-9 SDF
Synonyms NSC 354845, Tremortin A
Chemical Name (2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol
Canonical SMILES ClC1=C(C2)C3=C4C5=C([C@]([C@@H]([C@H]5OC(C)(C)[C@H]6[C@@]([C@@H](C2=C)C6)3O)CC7)(C)[C@@](CC8)(C)[C@]7([C@]9([C@H]8O[C@@H]%10C(C)=C)O[C@@H]9[C@H]%10O)O)NC4=C1
Formula C37H44ClNO6 M.Wt 634.2
Solubility 10mg/mL in ethanol, or in DMSO, or in DMF Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Penitrem A is an indole diterpene neurotoxic alkaloid produced by Penicillium, acts as a selective BK channel antagonist with antiproliferative and anti-invasive activities against multiple malignancies. Penitrem A increases the spontaneous release of endogenous glutamate, gamma-aminobutyric acid (GABA) and aspartate from cerebrocortical synaptosomes, and induces tremorgenic syndromes in animals[1][2].

[1]. Goda AA, et al. The Maxi-K (BK) Channel Antagonist Penitrem A as a Novel Breast Cancer-Targeted Therapeutic. Mar Drugs. 2018 May 11;16(5).
[2]. Norris PJ, et al. Actions of tremorgenic fungal toxins on neurotransmitter release. J Neurochem. 1980 Jan;34(1):33-42.