Plumbagin (Synonyms: NSC 236613, NSC 688284) |
Catalog No.GC10315
One-Click Copy Product Info
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A natural naphthoquinone
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 481-42-5
Sample solution is provided at 25 µL, 10mM.
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IC50: 11.69 μM for A549 cells
Plumbagin, a quinonoid constituent isolated from the root of Plumbago zeylanica L., has been shown to exert anticarcinogenic, antiatherosclerotic, and antimicrobial effects.
In vitro: Plumbagin exhibited effective cell growth inhibition via inducing cancer cells to undergo G2/M phase arrest and apoptosis. Blockade of cell cycle was associated with increased levels of p21 and reduced amounts of Cdc2, Cdc25C and cyclinB1. Plumbagin treatment also found to enhance the levels of inactivated phosphorylated Cdc2 and Cdc25C. Blockade of p53 activity partially decreased plumbagin-induced apoptosis and G2/M arrest, indicating it might be operated by p53-dependent and independent pathway [1].
In vivo: To determine whether plumbagin inhibited the in vivo tumor growth, A549 cells were injected into nude mice. Tumor growth inhibition was most evident in mice treated with plumbagin at 2 mg/kg/day, where around 80% reductions in tumor size were observed, in contrast with mice treated with the vehicle. No sign of toxicity was observed in plumbagin-treated mice as judged by monitoring body weight [1].
Clinical trial: N/A
Reference:
[1] Hsu YL,Cho CY,Kuo PL,Huang YT,Lin CC. Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) induces apoptosis and cell cycle arrest in A549 cells through p53 accumulation via c-Jun NH2-terminal kinase-mediated phosphorylation at serine 15 in vitro and in vivo. J Pharmacol Exp Ther.2006 Aug;318(2):484-94.
| Cas No. | 481-42-5 | SDF | |
| Synonyms | NSC 236613, NSC 688284 | ||
| Chemical Name | 5-hydroxy-2-methylnaphthalene-1,4-dione | ||
| Canonical SMILES | CC1=CC(=O)C2=C(C1=O)C=CC=C2O | ||
| Formula | C11H8O3 | M.Wt | 188.18 |
| Solubility | ≥ 6.35mg/mL in DMSO, ≥ 25.75 mg/mL in EtOH with ultrasonic | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.3141 mL | 26.5703 mL | 53.1406 mL |
| 5 mM | 1.0628 mL | 5.3141 mL | 10.6281 mL |
| 10 mM | 531.4 μL | 2.657 mL | 5.3141 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.50% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)