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Apoptosis Inducers

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Apoptosis, a programmed cell death to eliminate damaged or abnormal cells, is a highly organized physiological process characterized by condensation of nuclear heterochromatin, cell shrinkage and loss of positional organization of organelles in the cytoplasm. Apoptosis inducers are a collection of compounds that are capable of inducing apoptosis in cells. Apoptosis has been extensively studied in numerous researches, where induction of apoptosis has been associated with a variety of events, including activation of p53 gene, transcription factor NF-κB or caspases. Apoptosis inducers have the potential to be incorporated into the management and therapy or prevention of cancer for their ability to induce apoptosis in cancer cells.

Products Related to Apoptosis Inducers(42)

  • GC11834 structure
    GC11834Epibrassinolide
    CAS: 78821-43-9
    Purity: >98.00%

    Epibrassinolide is a ubiquitously occurring brassinosteroid plant growth hormone.

  • GC17198 structure
    GC17198Cycloheximide
    CAS: 66-81-9
    Purity: >98.00%

    Cycloheximide is an orally active antifungal antibiotic produced by Streptomyces griseus. Cycloheximide inhibits protein synthesis and RNA synthesis in vivo (IC 50 =532.5nM and 2880nM).

  • GC10282 structure
    GC10282Piperlongumine
    CAS: 20069-09-4
    Purity: >98.00%

    Piperlongumine is a natural alkaloid compound extracted from Piper longum L. , which has multiple pharmacological activities, including anti-tumor, lipid metabolism regulation, anti-platelet aggregation and analgesic activities.

  • GC10315 structure
    GC10315Plumbagin
    CAS: 481-42-5
    Purity: >98.50%

    A natural naphthoquinone

  • GC10480 structure
    GC10480Betulinic acid
    CAS: 472-15-1
    Purity: >98.00%

    Betulinic acid is a natural pentacyclic triterpenoid compound and an inhibitor of eukaryotic topoisomerase I with an IC 50 value of 5 μM.

  • GC10661 structure
    GC10661Destruxin B
    CAS: 2503-26-6
    Purity: >98%

    insecticidal and phytotoxic activity;induces apoptosis

  • GC10744 structure
    GC10744Bendamustine HCl
    CAS: 3543-75-7
    Purity: >98.50%

    Bendamustine HCl (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine HCl activats DNA-damage stress response and apoptosis. Bendamustine HCl has potent alkylating, anticancer and antimetabolite properties.

  • GC11632 structure
    GC11632Brassinolide
    CAS: 72962-43-7
    Purity: >98.00%

    Brassinolide is a plant sterol first isolated from pollen of rape ( Brassica napus L. ) and play major roles in plant growth, development, and stress tolerance.

  • GC11710 structure
    GC11710CFM 4
    CAS: 331458-02-7
    Purity: >98%

    CFM 4 is a potent small molecular antagonist of CARP-1/APC-2 binding. CFM 4 prevents CARP-1 binding with APC-2, causes G2M cell cycle arrest, and induces apoptosis with an IC50 range of 10-15 μM. CFM 4 also suppresses growth of drug-resistant human breast cancer cells.

  • GC11988 structure
    GC1198815-acetoxy Scirpenol
    CAS: 2623-22-5
    Purity: >98%

    mycotoxin that induce apoptotic cell death

  • GC12053 structure
    GC12053BAM7
    CAS: 331244-89-4
    Purity: >99.00%

    A direct activator of Bax

  • GC12139 structure
    GC12139Gambogic Acid
    CAS: 2752-65-0
    Purity: >98%

    Gambogic Acid A cell-permeable caspase activator and apoptosis inducer commonly used in studies of breast, lung, and liver cancers.

  • GC12258 structure
    GC122582,3-DCPE hydrochloride
    CAS: 1009555-55-8
    Purity: >98.00%

    2,3-DCPE hydrochloride induces apoptosis and downregulates Bcl-XL expression.

  • GC12649 structure
    GC12649TW-37
    CAS: 877877-35-5
    Purity: >99.00%

    An inhibitor of the Bcl-2 family proteins

  • GC12791 structure
    GC127913,3'-Diindolylmethane
    CAS: 1968-05-4
    Purity: >98.00%

    A phytochemical with antiradiation and chemopreventative effects

  • GC12857 structure
    GC12857R1530
    CAS: 882531-87-5
    Purity: >99.00%

    A multi-kinase inhibitor

  • GC12961 structure
    GC12961Apicidin
    CAS: 183506-66-3
    Purity: >90.00%

    A cell-permeable HDAC inhibitor

  • GC13034 structure
    GC13034ML-291
    CAS: 1523437-16-2
    Purity: >98%

    ML-291 is a UPR (unfolded protein response)-inducing sulfonamidebenzamide. ML-291 overwhelms the adaptive capacity of the UPR and induces apoptosis in a variety of solid cancer models. ML-291 can activate the PERK/eIF2a/CHOP (apoptotic) arm of the UPR and reduce leukemic cell burden.

  • GC14050 structure
    GC14050MPI-0441138
    CAS: 827030-33-1
    Purity: >98%

    inducer of apoptosis and growth inhibition

  • GC14065 structure
    GC14065Capsaicin
    CAS: 404-86-4
    Purity: >99.50%

    Capsaicin is a highly selective agonist for the transient receptor potential cation channel, subfamily V, member 1 (TRPV1), a ligand-gated, nonselective cation channel, preferentially expressed on small-diameter sensory neurons.

  • GC14787 structure
    GC14787Curcumin
    CAS: 458-37-7
    Purity: >98.00%

    A yellow pigment with diverse biological activities

  • GC14791 structure
    GC14791F16
    CAS: 36098-33-6
    Purity: >98.00%

    potential antitumor agent

  • GC14847 structure
    GC14847Psoralidin
    CAS: 18642-23-4
    Purity: >98.00%

    apoptosis inducer

  • GC14860 structure
    GC14860Oncrasin 1
    CAS: 75629-57-1
    Purity: >99.50%

    An anticancer agent