Porcupine

Porcupine (Porc) protein may be involved in secretion or ER transport, as Wingless is retained in the ER in porcupine mutant Drosophila embryos. In C. elegans, the porcupine homolog mom-1 has a similar function in promoting secretion of the Wnt protein Mom-2. Porcupine has some homology to a family of o-acyl transferases and may be involved in lipid modification of Wnt proteins. A special form of monounsaturated palmitoylation has been detected on a serine residue in the Wnt protein and could be mediated by porc as well. The human Porcupine gene is implicated in a genetic disease, Focal dermal hypoplasia. Porcupine, encodes a multipass transmembrane ER protein, which is required for normal distribution of Wg in embryos. Porc stimulates the processing of Wg when expressed in Drosophila cells in vitro and is also necessary for the localization of Drosophila Wnt-3 on the axon tracts of the embryonic central nervous system.

Products Related to Porcupine(6)

GC12392 LGK-974
CAS: 1243244-14-5
Purity: >99.50%
LGK-974 is a potent and specific inhibitor of Porcupine (PORCN).
GC13658 Wnt-C59
CAS: 1243243-89-1
Purity: >99.50%
Wnt-C59 is a highly potent inhibitor of Porcupine (Porcn), a member of the Mboat (membrane-bound O-acyl deglycosylase) family, with an IC 50 value of 74pM, and can inhibit Wnt signaling.
GC17708 IWP-L6
CAS: 1427782-89-5
Purity: >99.50%
Porcupine inhibitor,highy potent
GC19299 Porcupine-IN-1
CAS: 2036044-77-4
Purity: >99.00%
Porcupine-IN-1 is potent porcupine inhibitor with an IC50 of 0.5±0.2 nM.
GC32877 GNF-6231
CAS: 1243245-18-2
Purity: >99.50%
GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.
GC34628 IWP-O1
CAS: 2074607-48-8
Purity: >99.00%
IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells. IWP-O1 prevents the secretion of Wnt proteins. IWP-O1 suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC12392	LGK-974	1243244-14-5	>99.50%
GC12392	LGK-974 is a potent and specific inhibitor of Porcupine (PORCN).
GC13658	Wnt-C59	1243243-89-1	>99.50%
GC13658	Wnt-C59 is a highly potent inhibitor of Porcupine (Porcn), a member of the Mboat (membrane-bound O-acyl deglycosylase) family, with an IC 50 value of 74pM, and can inhibit Wnt signaling.
GC17708	IWP-L6	1427782-89-5	>99.50%
GC17708	Porcupine inhibitor,highy potent
GC19299	Porcupine-IN-1	2036044-77-4	>99.00%
GC19299	Porcupine-IN-1 is potent porcupine inhibitor with an IC50 of 0.5±0.2 nM.
GC32877	GNF-6231	1243245-18-2	>99.50%
GC32877	GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.
GC34628	IWP-O1	2074607-48-8	>99.00%
GC34628	IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells. IWP-O1 prevents the secretion of Wnt proteins. IWP-O1 suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.