Prohexadione is a plant growth regulator.1 It inhibits the gibberellin plant hormone biosynthesis enzyme 3β-hydroxylase when used at concentrations of 0.1, 1, and 10 mM. It reduces the shoot length of peanut plants when applied at 0.5, 1.5, and 4.5 kg/hectare. Prohexadione also inhibits jumonji domain-containing 2A (JMJD2A) demethylase when used at a concentration of 1 mM and induces the differentiation of mouse neurospheres into neurons at 1, 1.5, and 2 mM.2 Formulations containing prohexadione have been used as plant growth regulators in agriculture.
1.Brown, R.G.S., Kawaide, H., Yang, Y.-Y., et al.Daminozide and prohexadione have similar modes of action as inhibitors of the late stages of gibberellin metabolismPhysiol. Plant.101(2)309-313(1997) 2.Vavilala, D.T., Reddy, S., Sachchidanand, et al.Prohexadione, a plant growth regulator, inhibits histone lysine demethylases and modulates epigeneticsToxicol. Rep.11152-1161(2014)