Proteins

Mipomersen sodium scrambled negative control is the sequence scrambled negative control of Mipomersen sodium.

EAD1 trihydrochloride is a Chloroquine analog with anticancer activity.

Cusculine (FAC21) is an oropouche virus (OROV) endonuclease inhibitor with an IC 50 of 1.4 μM.

CDH11-IN-1 is a CDH11 inhibitor.

BAS00093476 is an E-cadherin inhibitor.

BAS00602705 is an E-cadherin inhibitor.

Pitstop 2c is a clathrin terminal domain inhibitor with an IC 50 of 1.8 μM.

Type IV collagen peptide acetate is a cell-binding ligand peptide derived from type IV collagen.

CAST-calpain-2 stabilizer-1 is a blood-brain barrier permeable stabilizer of CAST-calpain-2 interaction.

Snail IN-1 is an orally active Snail inhibitor with a Ka of 0.36 μM.Snail IN-1 disrupts Snail - CBP interaction, accelerates Snail protein degradation, reduces Snail acetylation, increases Snail polyubiquitination, and selectively downregulates Snail protein without altering other EMT transcription factors.Snail IN-1 reduces atherosclerotic plaque burden, modulates inflammation and plaque stability factors, downregulates CCL5, CXCL10, MMP2, and MMP9, and upregulates α-smooth muscle actin.Snail IN-1 exerts anti-inflammatory and plaque-stabilizing properties.Snail IN-1 can be used for the research of atherosclerosis [1] .

Lepodisiran (LY3819469) is a GalNAc-conjugated small interfering RNA lipid-lowering agent.

BBO-11818 is an orally active, highly selective (relative to NRAS and HRAS ), non-covalent pan- KRAS inhibitor ( IC 50 =28-120 nM).

RM-046 is an orally active, selective ternary complex inhibitor of KRAS Q61H (active form).

CCKBR agonist-1 (Compound 3r1) is a Gq-protein-preferring cholecystokinin B receptor ( CCKBR ) agonist with an EC 50 of 35 pM.

Zareprumig is a human monoclonal antibody targeting CD20/MS4A1&CD71/TFRC [1] .

LY3541860 is a selective anti- CD19 antibody that both binds human CD19 with high affinity and selectively binds human B cells ( K d values: 76.8 pM and 94.5 nM for humans and cynomolgus monkeys, respectively).

Anti-CD19 Antibody (FMC63) is an antibody that binds to CD19, with a human K d value ranging from 0.42 nM to 149 nM.

Zeclantamig is an immunoglobuline (H-gamma1_L-kappa)_scFvhk-G1(h-CH2-CH3), anti-[ Homo sapiens EPCAM et anti-[ Homo sapiens CD3E ], anticorps monoclonal chimérique, bispécifique, trivalent [1] .

CD38-IN-6 is an orally active CD38 inhibitor.

ADU-1805 is a humanized monoclonal IgG2 antibody, a selective, pan-allelic anti- SIRPα antibody, with a K d value of 11.0 × 10 -9 M for hSIRPαV1.

ZX-J-19L is a CyPJ inhibitor with inhibitory activity against a variety of tumor cell lines.

4L2-P13D is an IL-11 antagonist with an IC 50 of 2.8 μM.

DKFZ-251 is a kininogenase-related peptidase KLK6 inhibitor ( IC 50 =0.47 μM), and also exhibits certain inhibitory activity against KLK5 and KLK7 ( IC 50 values are 1.1 nM and 73 nM, respectively).

KVD-001 is a potent plasma kallikrein inhibitor.