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Monoamine Oxidase

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Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. They belong to the protein family of flavin-containing amine oxidoreductases. Monoamine oxidases catalyze the oxidative deamination of monoamines. Oxygen is used to remove an amine group from a molecule, resulting in the corresponding aldehyde and ammonia. Monoamine oxidases contain the covalently bound cofactor FAD and are, thus, classified as flavoproteins. Because of the vital role that MAOs play in the inactivation of neurotransmitters, MAO dysfunction is thought to be responsible for a number of psychiatric and neurological disorders. MAO-A inhibitors act as antidepressant and antianxiety agents, whereas MAO-B inhibitors are used alone or in combination to treat Alzheimer’sand Parkinson’s diseases.

Products Related to Monoamine Oxidase(100)

  • GC31021 structure
    GC310212614W94
    CAS: 205187-35-5
    Purity: >98%

    2614W94 is a selective, reversible inhibitor of monoamine oxidase-A with a competitive mechanism of inhibition and IC50 of 5 nM and Ki of 1.6 nM with serotonin as substrate.

  • GC31024 structure
    GC31024RS 8359
    CAS: 105365-76-2
    Purity: >98%

    RS 8359 is a selective and reversible MAO-A inhibitor, with antidepressant activity.

  • GC31094 structure
    GC31094CR4056
    CAS: 1004997-71-0
    Purity: >98%
  • GC31104 structure
    GC31104Isocarboxazid
    CAS: 59-63-2
    Purity: >98.50%

    An inhibitor of MAO

  • GC31155 structure
    GC31155CX-157
    CAS: 205187-53-7
    Purity: >98%

    CX-157 is a reversible inhibitor of monoamine oxidase-A (MAO-A) with an EC50 of 19.3?ng/mL.

  • GC31252 structure
    GC31252MAO-IN-1
    CAS: 124991-40-8
    Purity: >99.00%

    MAO-IN-1 is a monoamine oxidase B (MAO B) inhibitor with an IC50 of 20 nM.

  • GC31890 structure
    GC31890PXS-5153A
    CAS: 2125956-82-1
    Purity: >98%

    PXS-5153A is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC50 of <40 nM for LOXL2 across all mammalian species and an IC50 of 63 nM for human LOXL3.

  • GC31949 structure
    GC31949PAT-1251 Hydrochloride
    CAS: 2098884-53-6
    Purity: >98%

    PAT-1251 is a lysyl oxidase-like 2 (LOXL2; IC 50 =0.71μM) inhibitor.

  • GC32764 structure
    GC32764GSK-LSD1 Dihydrochloride
    CAS: 2102933-95-7
    Purity: >98.00%

    An LSD1 inhibitor

  • GC33573 structure
    GC33573Rasagiline 13C3 mesylate racemic (AGN1135 13C3 racemic)
    CAS: 1216757-55-9
    Purity: >98%

    Rasagiline 13C3 mesylate racemic (AGN1135 13C3 racemic) is a 13C-labeled Rasagiline mesylate racemic.

  • GC33677 structure
    GC33677Iproniazid phosphate
    CAS: 305-33-9
    Purity: >98.00%

    Iproniazid phosphate is a non-selective, irreversible monoamine oxidase (MAO) inhibitor of the hydrazine class.

  • GC33686 structure
    GC33686(S)-Rasagiline (TVP1022)
    CAS: 185517-74-2
    Purity: >99.00%

    (S)-Rasagiline (TVP1022) (TVP1022) is the relatively inactive S-enantiomer form of Rasagiline.

  • GC33714 structure
    GC33714Rasagiline (AGN1135)
    CAS: 136236-51-6
    Purity: >98.50%

    Rasagiline (AGN1135) (R-AGN1135) is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC50s of 4.43nM and 412nM for rat brain MAO B and A activity, respectively.

  • GC33718 structure
    GC33718Brofaromine (CGP 11305A)
    CAS: 63638-91-5
    Purity: >98.50%

    Brofaromine (CGP 11305A) (CGP 11305A) is a monoamine oxidase (MAO) inhibitor with IC50 of 0.2μM for MAO-A.

  • GC33749 structure
    GC33749Salsolidine
    CAS: 5784-74-7
    Purity: >98%

    Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor.

  • GC33983 structure
    GC33983Amitraz (BTS-27419)
    CAS: 33089-61-1
    Purity: >98%

    Amitraz (BTS-27419) is a non-systemic acaricide and insecticide, with alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis.

  • GC34842 structure
    GC34842Toloxatone
    CAS: 29218-27-7
    Purity: >99.00%

    An inhibitor of MAO-A

  • GC35006 structure
    GC35006(S)-Rasagiline mesylate
    CAS: 202464-88-8
    Purity: >98%

    (S)-Rasagiline (TVP1022) mesylate is the relatively inactive S-enantiomer form of Rasagiline mesylate.

  • GC35192 structure
    GC351927-Hydroxy-3,4-dihydro-2(1H)-quinolinone
    CAS: 22246-18-0
    Purity: >99.50%

    7-?Hydroxy-?3,?4-?dihydro-?2(1H)?-?quinolinone (3,4-Dihydro-7-hydroxy-2(1H)-quinolinone) is a weak MAO-A inhibitor, with an IC50 of 183 μM, and has no effect on MAO-B.

  • GC36638 structure
    GC36638Mofegiline hydrochloride
    CAS: 120635-25-8
    Purity: >98%

    Mofegiline hydrochloride (MDL72974A) is an orally active and selective enzyme-activated irreversible inhibitor of MAO-B, with marked selectivity on the MAO-B over MAO-A with IC50s of 3.6 nM (MAO-B) and 680 nM (MAO-A), respectively.

  • GC36853 structure
    GC36853Pargyline
    CAS: 555-57-7
    Purity: >98.00%

    Pargyline is an irreversible monoamine oxidase (MAO) inhibitor with Kis of 13 μM and 0.5 μM for MAO-A and MAO-B, respectively.

  • GC37558 structure
    GC37558Rosmarinic acid racemate
    CAS: 537-15-5
    Purity: >98%
  • GC38583 structure
    GC38583PXS-5153A monohydrochloride
    Purity: >99.50%

    PXS-5153A monohydrochloride is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC50 of <40 nM for LOXL2 across all mammalian species and an IC50 of 63 nM for human LOXL3.

  • GC39018 structure
    GC39018Obtusin
    CAS: 70588-05-5
    Purity: >98%

    Obtusin, isolated from Cassia obtusifolia Linn seed, is a highly selective and competitive human monoamine oxidase-A (hMAO-A) inhibitor with an IC50 of 11.12 μM and a Ki of 6.15 μM.