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Monoamine Oxidase

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Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. They belong to the protein family of flavin-containing amine oxidoreductases. Monoamine oxidases catalyze the oxidative deamination of monoamines. Oxygen is used to remove an amine group from a molecule, resulting in the corresponding aldehyde and ammonia. Monoamine oxidases contain the covalently bound cofactor FAD and are, thus, classified as flavoproteins. Because of the vital role that MAOs play in the inactivation of neurotransmitters, MAO dysfunction is thought to be responsible for a number of psychiatric and neurological disorders. MAO-A inhibitors act as antidepressant and antianxiety agents, whereas MAO-B inhibitors are used alone or in combination to treat Alzheimer’sand Parkinson’s diseases.

Products Related to Monoamine Oxidase(100)

  • GC39187 structure
    GC39187Azure B
    CAS: 531-55-5
    Purity: >98%

    Azure B is a cationic dye and the major metabolite of Methylene blue.

  • GC39603 structure
    GC39603Methylene blue trihydrate
    CAS: 7220-79-3
    Purity: >99.00%

    Methylene blue trihydrate (C.

  • GC50329 structure
    GC50329M 30 dihydrochloride
    CAS: 64821-19-8
    Purity: >98.50%

    M 30 dihydrochloride is an orally active, brain-permeable, and brain selective irreversible MAO-A (IC50=37 nM) and MAO-B (IC50=57 nM) inhibitor.

  • GC60004 structure
    GC60004(rel)-Tranylcypromine D5 hydrochloride
    CAS: 107077-98-5
    Purity: >98.00%

    Tranylcypromine-d5 (SKF 385-d5) hydrochloride is a deuterium labeled (rel)-Tranylcypromine hydrochloride.

  • GC60519 structure
    GC605194-Hydroxyderricin
    CAS: 55912-03-3
    Purity: >98.00%

    4-Hydroxyderricin, the major active ingredients of Angelica keiskei Koidzumi, is a potent selective MAO-B (Monoamine oxidase inhibitors) inhibitor with an IC50 of 3.43 μM.

  • GC60917 structure
    GC60917Hydroxyamine hydrochloride
    CAS: 5470-11-1
    Purity: >99.00%

    Hydroxyamine hydrochloride is a selective monoamine oxidase (MAO) inhibitor used for inhibiting of platelet aggregation.

  • GC60939 structure
    GC60939Iproniazid
    CAS: 54-92-2
    Purity: >98.00%

    Iproniazid is a non-selective, irreversible monoamine oxidase (MAO) inhibitor of the hydrazine class.

  • GC61162 structure
    GC61162Osthenol
    CAS: 484-14-0
    Purity: >98.50%

    Osthenol (Ostenol), a prenylated coumarin isolated from the dried roots of Angelica pubescens, is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 ?M).

  • GC61255 structure
    GC61255Rubrofusarin triglucoside
    CAS: 245724-07-6
    Purity: >98%

    Rubrofusarin triglucoside is a glycoside compound isolated from Cassia obtusifolia Linn seeds.

  • GC61382 structure
    GC61382Xanthoangelol
    CAS: 62949-76-2
    Purity: >98.00%

    Xanthoangelol, extracted from Angelica keiskei, suppresses obesity-induced inflammatory responses.

  • GC61983 structure
    GC61983β-Aminopropionitrile
    CAS: 151-18-8
    Purity: >99.50%

    β-Aminopropionitrile (BAPN) is a specific irreversible lysine oxidase (LOX) inhibitor with an IC 50 value of approximately 3-8μM.

  • GC62202 structure
    GC62202PXS-4728A
    CAS: 1478364-68-9
    Purity: >99.50%

    PXS-4728A (BI-1467335) is a selective, orally active inhibitor of semicarbazide-sensitive amine oxidase (SSAO).

  • GC62462 structure
    GC62462LOX-IN-3
    CAS: 2409963-83-1
    Purity: >98.00%

    LOX-IN-3 is an orally active lysyl oxidase (LOX) inhibitor. LOX-IN-3 can be used for fibrosis, cancer and angiogenesis research.

  • GC62706 structure
    GC62706Contezolid
    CAS: 1112968-42-9
    Purity: >98%

    Contezolid (MRX-I), a new and orally active oxazolidinone, is an antibiotic in study for complicated skin and soft tissue infections (cSSTI) caused by resistant Gram-positive bacteria.

  • GC62726 structure
    GC62726(±)-Amiflamine
    CAS: 77502-96-6
    Purity: >98%

    (±)-Amiflamine (FLA 336) is a potent monoamine oxidase-A (MAO-A) inhibitor with a pIC50 of 5.57.

  • GC63035 structure
    GC63035Kynuramine dihydrochloride
    CAS: 36681-58-0
    Purity: >99.50%

    Kynuramine, an endogenously occurring amine, is a fluorescent substrate and probe of plasma amine oxidase.

  • GC63038 structure
    GC63038Ladostigil
    CAS: 209394-27-4
    Purity: >98%

    Ladostigil (TV-3326) is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC50s of 37.1 and 31.8 μM for MAO-B and AChE, respectively.

  • GC63158 structure
    GC63158PXS-5120A
    CAS: 2125955-70-4
    Purity: >98%

    PXS-5120A is a potent, irreversible fluoroallylamine inhibitor of Lysyl Oxidase-like 2/3 (LOXL2/3) with anti-fibrotic activity.

  • GC63466 structure
    GC63466Ladostigil hemitartrate
    CAS: 209394-46-7
    Purity: >98%

    Ladostigil (TV-3326) hemitartrate is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC50s of 37.1 and 31.8 μM for MAO-B and AChE, respectively.

  • GC63556 structure
    GC63556Methyl citrate
    CAS: 26163-61-1
    Purity: >98.00%

    Methyl citrate is a Monoamine oxidase B (MAO-B) inhibitor (IC50=0.23 mM).

  • GC64009 structure
    GC64009MAO-B-IN-2
    CAS: 1253978-24-3
    Purity: >98%

    MAO-B-IN-2 is a selective and competitive inhibitor of MAO-B and BChE with IC50 values of 0.51 and 7.00 μM, respectively.

  • GC64656 structure
    GC64656LOX-IN-3 dihydrochloride
    CAS: 2409964-23-2
    Purity: >98.00%

    LOX-IN-3 dihydrochloride is an orally active lysyl oxidase (LOX) inhibitor. LOX-IN-3 dihydrochloride can be used for fibrosis, cancer and angiogenesis research.

  • GC65609 structure
    GC65609Glicoricone
    CAS: 161099-37-2
    Purity: >96.00%

    Glicoricone, a phenolic compound, is isolated from a species of licorice.

  • GC68299 structure
    GC68299Simtuzumab
    CAS: 1318075-13-6
    Purity: >98%