Serotonin Transporter
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Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.
Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available.
Products Related to Serotonin Transporter(61)
- GC18497DapoxetineCAS: 119356-77-3Purity: >99.50%
Dapoxetine hydrochloride (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI).
- GC19117DasotralineCAS: 675126-05-3Purity: >98%
Dasotraline is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.
- GC19118Dasotraline hydrochlorideCAS: 675126-08-6Purity: >99.50%
Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.
- GC25708Paroxetine mesylateCAS: 217797-14-3Purity: >98%
Paroxetine Mesylate(BRL-29060A mesylate,FG-7051 mesylate) is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties.
- GC30375Clomipramine D3CAS: 136765-29-2Purity: >98%
Clomipramine D3 (Chlorimipramine-d3) is the deuterium labeled Clomipramine.
- GC30981Amitifadine hydrochloride (DOV-21947 hydrochloride)CAS: 410074-74-7Purity: >99.50%
Amitifadine hydrochloride (DOV-21947 hydrochloride) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with IC50s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively.
- GC30992Paroxetine hydrochloride hemihydrate (BRL29060 hydrochloride hemihydrate)CAS: 110429-35-1Purity: >98%
Paroxetine hydrochloride hemihydrate (BRL29060 hydrochloride hemihydrate) is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an antidepressant and has GRK2 inhibitory ability with IC50 of 14μM.
- GC31020SPD-473 citrateCAS: 161190-26-7Purity: >98%
SPD-473 citrate is a serotonin/dopamine/norepinephrine reuptake inhibitior.
- GC31029Nitroxazepine (CIBA 2330Go)CAS: 47439-36-1Purity: >98%
Nitroxazepine (CIBA 2330Go) is a tricyclic antidepressant (TCA) for the research of depression.
- GC31064Duloxetine ((S)-Duloxetine)CAS: 116539-59-4Purity: >98.00%
Duloxetine ((S)-Duloxetine) is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).
- GC31175Centanafadine hydrochloride (EB-1020 (hydrochloride))CAS: 923981-14-0Purity: >99.50%
Centanafadine (hydrochloride) is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively.
- GC31283Centanafadine (EB-1020)CAS: 924012-43-1Purity: >98%
Centanafadine (EB-1020) is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively.
- GC33715Fluoxetine (LY-110140)CAS: 54910-89-3Purity: >99.50%
Fluoxetine (LY-110140) is an orally active, selective serotonin reuptake inhibitor (SSRI) commonly used to treat a variety of psychiatric disorders such as depression, obsessive-compulsive disorder, and panic disorder.
- GC34559DOV-216,303 Free BaseCAS: 66504-40-3Purity: >98.00%
DOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively.
- GC34575Eplivanserin mixtureCAS: 130581-13-4Purity: >99.50%
Eplivanserin mixture (SR-46349 mixture) is a selective serotonin reuptake inhibitor and a 5-HT2A receptor antagonist, extracted from patent WO 2005/002578 A1.
- GC35444Azaphen dihydrochloride monohydrateCAS: 63302-99-8Purity: >99.50%
Pipofezine(Azafen or Azaphen) is a potent inhibitor of the reuptake of serotonin.
- GC37906Vilazodone D8CAS: 1794789-93-7Purity: >98%
Vilazodone D8 is the a deuterium labeled vilazodone, which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist.
- GC44057Levomilnacipran (hydrochloride)CAS: 175131-60-9Purity: >98.00%
Milnacipran (1S-cis) hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI), used in the clinical treatment of fibromyalgia.
- GC47101Clomipramine-d3 (hydrochloride)CAS: 1398065-86-5Purity: >99.50%
An Analytical Reference Standard
- GC47277Duloxetine-d3 (hydrochloride)CAS: 1188266-11-6Purity: >99.00%
An internal standard for the quantification of duloxetine
- GC48255Vortioxetine-d8CAS: 2140316-62-5Purity: >99.00%
An internal standard for the quantification of vortioxetine
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC18497 | Dapoxetine | 119356-77-3 | >99.50% | |
Dapoxetine hydrochloride (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). | ||||
| GC19117 | Dasotraline | 675126-05-3 | >98% | |
Dasotraline is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively. | ||||
| GC19118 | Dasotraline hydrochloride | 675126-08-6 | >99.50% | |
Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively. | ||||
| GC25708 | Paroxetine mesylate | 217797-14-3 | >98% | |
Paroxetine Mesylate(BRL-29060A mesylate,FG-7051 mesylate) is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. | ||||
| GC30375 | Clomipramine D3 | 136765-29-2 | >98% | |
Clomipramine D3 (Chlorimipramine-d3) is the deuterium labeled Clomipramine. | ||||
| GC30772 | Dopamine serotonin antagonist-1 | 1977-07-7 | >98% | |
| GC30981 | Amitifadine hydrochloride (DOV-21947 hydrochloride) | 410074-74-7 | >99.50% | |
Amitifadine hydrochloride (DOV-21947 hydrochloride) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with IC50s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively. | ||||
| GC30992 | Paroxetine hydrochloride hemihydrate (BRL29060 hydrochloride hemihydrate) | 110429-35-1 | >98% | |
Paroxetine hydrochloride hemihydrate (BRL29060 hydrochloride hemihydrate) is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an antidepressant and has GRK2 inhibitory ability with IC50 of 14μM. | ||||
| GC31020 | SPD-473 citrate | 161190-26-7 | >98% | |
SPD-473 citrate is a serotonin/dopamine/norepinephrine reuptake inhibitior. | ||||
| GC31029 | Nitroxazepine (CIBA 2330Go) | 47439-36-1 | >98% | |
Nitroxazepine (CIBA 2330Go) is a tricyclic antidepressant (TCA) for the research of depression. | ||||
| GC31041 | Wf-516 | 310392-94-0 | >98% | |
Wf-516 is an inhibitor of 5-HT reuptake, and an antagonist of 5-HT1A and 5-HT2A receptors, with Ki of 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively, and has potent antidepressant activity. | ||||
| GC31064 | Duloxetine ((S)-Duloxetine) | 116539-59-4 | >98.00% | |
Duloxetine ((S)-Duloxetine) is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD). | ||||
| GC31175 | Centanafadine hydrochloride (EB-1020 (hydrochloride)) | 923981-14-0 | >99.50% | |
Centanafadine (hydrochloride) is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively. | ||||
| GC31283 | Centanafadine (EB-1020) | 924012-43-1 | >98% | |
Centanafadine (EB-1020) is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively. | ||||
| GC33715 | Fluoxetine (LY-110140) | 54910-89-3 | >99.50% | |
Fluoxetine (LY-110140) is an orally active, selective serotonin reuptake inhibitor (SSRI) commonly used to treat a variety of psychiatric disorders such as depression, obsessive-compulsive disorder, and panic disorder. | ||||
| GC34559 | DOV-216,303 Free Base | 66504-40-3 | >98.00% | |
DOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. | ||||
| GC34575 | Eplivanserin mixture | 130581-13-4 | >99.50% | |
Eplivanserin mixture (SR-46349 mixture) is a selective serotonin reuptake inhibitor and a 5-HT2A receptor antagonist, extracted from patent WO 2005/002578 A1. | ||||
| GC35443 | Azaphen | 24853-80-3 | >98% | |
Pipofezine(Azafen or Azaphen) is a potent inhibitor of the reuptake of serotonin. | ||||
| GC35444 | Azaphen dihydrochloride monohydrate | 63302-99-8 | >99.50% | |
Pipofezine(Azafen or Azaphen) is a potent inhibitor of the reuptake of serotonin. | ||||
| GC37906 | Vilazodone D8 | 1794789-93-7 | >98% | |
Vilazodone D8 is the a deuterium labeled vilazodone, which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist. | ||||
| GC44057 | Levomilnacipran (hydrochloride) | 175131-60-9 | >98.00% | |
Milnacipran (1S-cis) hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI), used in the clinical treatment of fibromyalgia. | ||||
| GC47101 | Clomipramine-d3 (hydrochloride) | 1398065-86-5 | >99.50% | |
An Analytical Reference Standard | ||||
| GC47277 | Duloxetine-d3 (hydrochloride) | 1188266-11-6 | >99.00% | |
An internal standard for the quantification of duloxetine | ||||
| GC48255 | Vortioxetine-d8 | 2140316-62-5 | >99.00% | |
An internal standard for the quantification of vortioxetine | ||||