Serotonin Transporter
Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.
Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available.
Targets for Serotonin Transporter
Products for Serotonin Transporter
- Cat.No. Product Name Information
- GC60394 (±)-Duloxetine hydrochloride (±)-Duloxetine ((Rac)-Duloxetine) hydrochloride is the racemate of Duloxetine hydrochloride.
- GC60424 (S)-Venlafaxine (S)-Venlafaxine is the (S)-configuration of Venlafaxine. Venlafaxine is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant agent.
- GC30981 Amitifadine hydrochloride (DOV-21947 hydrochloride) Amitifadine hydrochloride (DOV-21947 hydrochloride) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with IC50s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively.
- GC35443 Azaphen Pipofezine(Azafen or Azaphen) is a potent inhibitor of the reuptake of serotonin.
- GC35444 Azaphen dihydrochloride monohydrate Pipofezine(Azafen or Azaphen) is a potent inhibitor of the reuptake of serotonin.
- GC31283 Centanafadine (EB-1020) Centanafadine (EB-1020) is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively.
- GC31175 Centanafadine hydrochloride (EB-1020 (hydrochloride)) Centanafadine (hydrochloride) is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively.
- GC11798 Cinchonidine alkaloid
- GC14035 Citalopram hydrobromide 5-HT uptake inhibitor
- GC30375 Clomipramine D3 Clomipramine D3 (Chlorimipramine-d3) is the deuterium labeled Clomipramine.
- GC15107 Clomipramine HCl Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM.
- GC47101 Clomipramine-d3 (hydrochloride) An Analytical Reference Standard
- GC17061 Dapoxetine HCl Selective serotonin reuptake inhibitor
- GC18497 Dapoxetine hydrochloride Dapoxetine hydrochloride (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI).
- GC60740 Dapoxetine-D7 hydrochloride Dapoxetine-d7 (LY-210448-d7) hydrochloride is the deuterium labeled Dapoxetine hydrochloride.
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GC19117
Dasotraline
Dasotraline is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.
- GC19118 Dasotraline hydrochloride Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.
- GC10126 Desipramine hydrochloride noradrenalin transporters inhibitor
- GC11570 Desvenlafaxine serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor
- GC14262 Desvenlafaxine Succinate serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor
- GC30772 Dopamine serotonin antagonist-1
- GC34559 DOV-216,303 Free Base DOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively.
- GC65014 DSP-1053 DSP-1053, a benzylpiperidine derivative, is a potent?Serotonin Transporter (SERT) inhibitor with a Ki of 1.02 nM.
- GC31064 Duloxetine ((S)-Duloxetine) Duloxetine ((S)-Duloxetine) is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).
- GC13871 Duloxetine HCl Duloxetine HCl ((S)-Duloxetine HCl) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).
- GC47277 Duloxetine-d3 (hydrochloride) An internal standard for the quantification of duloxetine
- GC34575 Eplivanserin mixture Eplivanserin mixture (SR-46349 mixture) is a selective serotonin reuptake inhibitor and a 5-HT2A receptor antagonist, extracted from patent WO 2005/002578 A1.
- GC13161 Escitalopram Serotonin reuptake inhibitor
- GC16797 Escitalopram Oxalate Selective 5-HT reuptake inhibitor
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GC33715
Fluoxetine (LY-110140)
Fluoxetine (LY-110140) is an orally active selective serotonin reuptake inhibitor (SSRI). Fluoxetine is a potent inhibitor of the saturated [3H]-5-HT uptake process in rat and human platelets, with IC50 values of 0.10 and 0.05 μM, respectively.
- GC11709 Fluoxetine HCl Serotonin reuptake inhibitor,selective
- GC13092 Fluvoxamine Selective serotonin reuptake inhibitor
- GC15025 Fluvoxamine maleate Serotonin reuptake inhibitor,selective,antidepressant
- GC12885 Imipramine (hydrochloride) serotonin and norepinephrine transporters inhibitor
- GC65209 Imipramine-d4 hydrochloride
- GC44057 Levomilnacipran (hydrochloride) Milnacipran (1S-cis) hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI), used in the clinical treatment of fibromyalgia.
- GC14330 Milnacipran Serotonin-norepinephrine reuptake inhibitor (SNRI)
- GC12055 Milnacipran HCl Milnacipran HCl is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia.
- GC31029 Nitroxazepine (CIBA 2330Go) Nitroxazepine (CIBA 2330Go) is a tricyclic antidepressant (TCA) for the research of depression.
- GC17229 Paroxetine HCl Paroxetine HCl is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an and has GRK2 inhibitory ability with IC50 of 14μM.
- GC30992 Paroxetine hydrochloride hemihydrate (BRL29060 hydrochloride hemihydrate) Paroxetine hydrochloride hemihydrate (BRL29060 hydrochloride hemihydrate) is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an antidepressant and has GRK2 inhibitory ability with IC50 of 14μM.
- GC25708 Paroxetine mesylate Paroxetine Mesylate(BRL-29060A mesylate,FG-7051 mesylate) is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties.
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GC69880
SERT-IN-2
SERT-IN-2 is a potent SERT inhibitor (IC50=0.58 nM) with antidepressant activity. It has good bioavailability, with an F(%) of 83.28% in rats. SERT-IN-2 can cross the blood-brain barrier.
- GC12720 Sertraline HCl Sertraline HCl is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
- GC31020 SPD-473 citrate SPD-473 citrate is a serotonin/dopamine/norepinephrine reuptake inhibitior.
- GC10911 Venlafaxine hydrochloride Dual serotonin/noradrenalin re-uptake inhibitor
- GC15013 Vilazodone
- GC37906 Vilazodone D8 Vilazodone D8 is the a deuterium labeled vilazodone, which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist.
- GC10876 Vilazodone Hydrochloride An SSRI and a partial agonist of 5-HT1A
- GC16312 Vortioxetine A multimodal serotonergic agent
- GC14437 Vortioxetine (Lu AA21004) HBr Vortioxetine (Lu AA21004) HBr is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.
- GC48255 Vortioxetine-d8 An internal standard for the quantification of vortioxetine
- GC31041 Wf-516 Wf-516 is an inhibitor of 5-HT reuptake, and an antagonist of 5-HT1A and 5-HT2A receptors, with Ki of 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively, and has potent antidepressant activity.
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GC70178
ZZL-7
ZZL-7 is a fast-acting antidepressant. It works by disrupting the interaction between serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN). ZZL-7 can easily cross the blood-brain barrier and is used for research on major depressive disorder (MDD).