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Serotonin Transporter

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Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.

Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available.

Products Related to Serotonin Transporter(61)

  • GC60394 structure
    GC60394(±)-Duloxetine hydrochloride
    CAS: 947316-47-4
    Purity: >99.50%

    (±)-Duloxetine ((Rac)-Duloxetine) hydrochloride is the racemate of Duloxetine hydrochloride.

  • GC60424 structure
    GC60424(S)-Venlafaxine
    CAS: 93413-44-6
    Purity: >98%

    (S)-Venlafaxine is the (S)-configuration of Venlafaxine. Venlafaxine is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant agent.

  • GC60740 structure
    GC60740Dapoxetine-D7 hydrochloride
    CAS: 129938-20-1
    Purity: >99.50%

    Dapoxetine-d7 (LY-210448-d7) hydrochloride is the deuterium labeled Dapoxetine hydrochloride.

  • GC65014 structure
    GC65014DSP-1053
    CAS: 1176326-76-3
    Purity: >99.00%

    DSP-1053, a benzylpiperidine derivative, is a potent?Serotonin Transporter (SERT) inhibitor with a Ki of 1.02 nM.

  • GC65209 structure
    GC65209Imipramine-d4 hydrochloride
    CAS: 61361-33-9
    Purity: >99.50%
  • GC69880 structure
    GC69880SERT-IN-2
    CAS: 2055228-33-4
    Purity: >98.00%

    SERT-IN-2 is a potent SERT inhibitor (IC50=0.58 nM) with antidepressant activity. It has good bioavailability, with an F(%) of 83.28% in rats. SERT-IN-2 can cross the blood-brain barrier.

  • GC70178 structure
    GC70178ZZL-7
    CAS: 99141-91-0
    Purity: >98.00%

    ZZL-7 is a fast-acting antidepressant. It works by disrupting the interaction between serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN). ZZL-7 can easily cross the blood-brain barrier and is used for research on major depressive disorder (MDD).

  • GC70271 structure
    GC70271Ampreloxetine hydrochloride
    CAS: 1227056-87-2
    Purity: >99.00%

    Ampreloxetine (TD-9855) hydrochloride is an orally active and CNS-penetrant inhibitor of Norepinephrine transporter (NET) and Serotonin 5-HT uptake transporter (SERT), but not Dopamine transporter (DAT).

  • GC71618 structure
    GC71618rel-Sertraline-d3 hydrochloride
    CAS: 1330180-66-9

    rel-Sertraline-d3 (hydrochloride) is the deuterium labeled Sertraline hydrochloride.

  • GC71620 structure
    GC71620Venlafaxine-d6
    CAS: 1020720-02-8

    Venlafaxine-d6 is the deuterium labeled Venlafaxine.

  • GC79505 structure
    GC79505RPI-GLYT2-82
    Purity: >99.00%

    RPI-GLYT2-82 is a reversible, blood-brain barrier-permeable allosteric inhibitor of GlyT2 with an IC 50 value of 554 nM.

  • GC79780 structure
    GC79780SERT/5-HT-IN-1
    CAS: 3120534-54-2
    Purity: >99.00%

    SERT/5-HT-IN-1 (compound D17) is an orally active and potent dual target inhibitor of SERT/5-HT3A ( SERT IC 50 = 1.5 nM, NET IC 50 = 49 nM, DAT IC 50 = 91 nM, 5-HT3A K i = 12 nM).

  • GC79790 structure
    GC79790A6CDQ
    CAS: 1005550-46-8
    Purity: >98%

    A6CDQ is a human organic cation transporter ( hOCT ) inhibitor with antidepressant-like activity that can cross the blood-brain barrier.