mGluR

Inhibits glutamate release. Water-soluble salt of lamotrigine

Potent and selective group II mGlu antagonist; disodium salt of LY 341495

Potent and selective negative allosteric modulator of mGlu1 receptors; also mGlu1 inverse agonist

High affinity human mGlu5 antagonist

Potent and selective negative allosteric modulator of mGlu5 receptors

Selective positive allosteric modulator of mGlu2 receptors

VU 0469650 hydrochloride is a potent, selective and CNS-penetrated negative allosteric modulator of mGlu1 receptor, with an IC50 of 99 nM.

Negative allosteric modulator of mGlu7 receptors; brain penetrant

Caged Raseglurant

Potent mGlu5 positive allosteric modulator and agonist; binds allosteric site with high affinity

Potent and selective negative allosteric modulator of mGlu2 receptors

AZD-8529 mesylate is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.

AZD 2066 hydrate is a selective, orally active and brain-penetrant antagonist of mGluR5.

L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively.

LY367385 hydrochloride is a highly selective and potent mGluR1a antagonist.

HTL14242 (HTL0014242) is an advanced and orally active mGlu5 NAM with a pKi?and a pIC50 of 9.3 and 9.2, respectively.

Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039.

RO0711401 is a selective and orally active positive allosteric modulator of mGlu1 receptor with an EC50 of 56 nM.

AMN082 free base, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain.

MMPIP is an allosteric metabotropic glutamate receptor 7 (mGluR7) selective antagonist (KB values 24 -30 nM).

LY487379 is a selective human mGluR2 positive allosteric modulator (PAM).

VU0360172 is a potent and selective mGlu5 receptor positive allosteric modulator with an EC50 value of 16 nM and a Ki of 195 nM, respectively.