mGluR

CALP1 TFA is an eight-residue complementary peptide that binds to the calcium-binding sites (the EF hand) of calmodulin.

Auglurant (VU0424238) is a novel and selective mGlu5 antagonist with an IC50 value of 11 nM (rat) and an IC50 value of 14 nM (human).

L-Glutamine-13C5 (L-Glutamic acid 5-amide-13C5) is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.

BMS-984923 is an effective mGluR5 negative allosteric modulator with good affinity (Ki = 0.6 nM), oral bioavailability, and blood-brain barrier permeability. It can effectively inhibit the interaction between PrPC-mGluR5 and suppress pathological Aβo signals without affecting physiological glutamate signaling.

CVN636 is an orally effective selective mGluR7 allosteric agonist with an EC50 value of 7 nM for hu mGluR7. CVN636 has central nervous system (CNS) penetrance.

Fasoracetam (NS 105) is an activator of the metabotropic glutamate receptor (mGluR). Fasoracetam (NS 105) has potential in researching attention deficit hyperactivity disorder (ADHD) and Alzheimer's disease (AD).

L-Glutamine-13C5,15N2 is L-Glutamine labeled with 13C and 15N isotopes. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid that is abundant in the human body and involved in many metabolic processes. L-Glutamine provides a source of carbon for oxidation in certain cells.

L-Glutamine-5-13C is L-Glutamine with a 13C label. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid that is abundant in the human body and involved in many metabolic processes. L-Glutamine provides a source of carbon for oxidation in certain cells.

ML353 is a selective ligand for mGlu5 silent allosteric modulators (SAMs), with a Ki value of 18.2 nM. ML353 enhances the affinity of common allosteric sites, and is 20 times more potent than the previous mGlu5 SAM tool compound, 5mpep. ML353 has potential applications in addressing inherent activity of SAMs in vivo or as an active molecule blocker.

Valiglurax (VU0652957) is an orally effective selective positive allosteric modulator of mGlu4, with EC50 values of 64.6 nM and 197 nM for hmGlu4 and rmGlu4 GIRK, respectively. Valiglurax is a central nervous system (CNS) penetrant. Valiglurax can be used in research on Parkinson's disease.

CBiPES is a potent mGlu2 positive allosteric modulator with an EC50 value of 92.8 nM.

VU0364289 is a highly selective mGlu5 positive allosteric modulator (PAM) (binds to the MPEP site), with an EC50 of 1.6 µM.

VU6010572 is a potent and selective mGlu3 negative allosteric modulator with IC50 of 245 nM.

mGluR2 modulator 1 (compound 95) is a potent and BBB-penetrated mGluR2 (metabotropic glutamate receptor-2) positive allosteric modulator, with an EC50 of 0.03 μM.

mGluR5 antagonist-1 (compound 10) is a high-affinity mGluR5 antagonist, with an IC50 value of 11.5 nM. mGluR5 antagonist-1 has anti-depressant effect.

(rel)-Eglumegad ((rel)-LY354740) is a relative configuration of Eglumegad .

Eglumegad (LY354740) hydrochloride is a highly potent and selective group II (mGlu2/3) receptor agonist with IC50s of 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively.

LY456066 is a selective non-competitive metabotropic glutamate receptors (mGluR1) antagonist with an IC50 value of 52.0 nM.

AZD6538 is a potent, selective and brain penetrant mGluR5 negative allosteric modulator.

(S,S)-BMS-984923 is a less active (S,S)-enantiomer of BMS-984923.

VU0477573 is a brain-penetrant partial negative allosteric modulator of metabotropic glutamate receptor subtype 5 ( mGluR5 ).