Adaptive Immunity

15-keto Prostaglandin E2 (15-keto PGE2) is a metabolite of PGE2 formed by 15-hydroxy PGDH.

Naturally occurring phytochemicals such as turmeric (curcumin) have been found to inhibit the growth of tumor cells.

C6 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 D-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM).

C6 L-threo Ceramide (d18:1/6:0) is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.

C2 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.

An S1P 1 receptor agonist

FTY720 is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.

Isogarcinol is a polyprenylated benzophenone natural compound extracted from plants of the Garciniagenus. Isogarcinol is also an effective inhibitor of acetylcholinesterase (AChE; IC₅₀=1.13μM) and butyrylcholinesterase (BChE; IC₅₀=8.30μM).

1-Oleoyl-2-hydroxy-sn-glycero-3-PE is a naturally-occurring lysophospholipid and an analog of plasmalogen lysophosphatidylethanolamine.

Tyvelose is an unusual 3,6-dideoxyhexose terminal sugar and the immunodominant component of glycoprotein antigens in the parasitic helminth T.

Mycophenolic Acid β-D-Glucuronide is a metabolite of the immunosuppressant mycophenolic acid (MPA). Mycophenolic Acid β-D-Glucuronide shows anti-tumor activity and can be used in adenocarcinoma research.

Diets high in fiber contain plant lignan species that may be directly responsible for some observed health benefits of these diets.

trans-Urocanic acid is a major epidermal chromophore for the immunosuppressive effects of UV radiation that is produced in mammalian stratum corneum by the action of histidine ammonialyase on L-histidine.

Synthetic and natural alkyl phosphates, also known as phosphoantigens, stimulate the proliferation of γδ-T lymphocytes.

1-Palmitoyl-2-hydroxy-sn-glycero-3-PC is an abundant gonadal LPC (lysophosphatidylcholine).

Sphingosine-1-phosphate (S1P) lyase catalyzes the irreversible decomposition of S1P to hexadecanaldehyde and phosphoethanolamine.

3-Deaza-2'-deoxyadenosine strongly inhibits lymphocyte-mediated cytolysis with low cytotoxicity when applied at 100 μM.

8-Bromoguanosine is a brominated derivative of guanosine.

9-Deazaguanine is a purine nucleoside analog with oral activity, functioning as a potent inhibitor of purine nucleoside phosphorylase (PNP).

ABC34 is an inactive control probe for JJH260, the inhibitor of androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs).

Ac-ANW-AMC is a fluorescent substrate for the β5i (LMP7/PSMB8) subunit of the 20S immunoproteasome, with a maximum excitation wavelength of λEx=345nm and a maximum emission wavelength of λEm=445nm.

Ac-IEPD-AMC is a fluorogenic substrate for granzyme B.

AUY954 is an orally bioavailable and selective agonist of the sphingosine-1-phosphate receptor 1 (S1P1; EC50 = 1.2 nM for stimulating GTPγS binding to S1P1 in CHO cells).

FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine.