Apoptosis

5-Aminolevulinic acid-13C-1 (5-ALA-13C-1) hydrochloride is a 13C-labeled form of 5-Aminolevulinic acid hydrochloride. 5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) is an intermediate in the biosynthesis of heme in the body and serves as a precursor to porphyrins.

AK-778-XXMU is an effective inhibitor of DNA binding 2 (ID2) antagonist, with a KD of 129 nM. AK-778-XXMU can inhibit the migration and invasion of glioma cell lines, induce apoptosis, and more importantly, slow down tumor growth.

ASR-488 can activate mRNA binding protein CPEB1, induce apoptosis and inhibit the growth of bladder cancer cells.

BC-1258 is an activator of F-box/LRR-repeat protein 2 (FBXL2) that stabilizes and upregulates FBXL2 levels. BC-1258 induces apoptosis in tumor cells and significantly inhibits tumor formation in mice.

BH3 hydrochloride is a peptide that can penetrate the blood-brain barrier. It induces cell apoptosis by directly activating pro-apoptotic Bax/Bak or neutralizing anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, Bcl-w, mcl1 and A-1) through binding to the BH3 domain.

Biotin-COG1410 TFA is a biotinylated form of COG1410, which is a derivative peptide of apolipoprotein E and an apoptosis inhibitor. COG1410 has been shown to have neuroprotective and anti-inflammatory effects in a mouse model of traumatic brain injury (TBI). COG1410 can be used for research on neurological disorders.

Bleomycin A5 (Pingyangmycin) is a glycopeptide antibiotic with oral activity. Bleomycin A5 has anti-tumor, apoptosis-inducing and bacterial metabolite effects.

Cantrixil (TRX-E-002-1) is the active enantiomer of TRX-E-002 and a second-generation superbenzopyran compound. Cantrixil increases phosphorylation levels of c-Jun, leading to caspase-mediated apoptosis in ovarian cancer cells. Cantrixil has effective anti-cancer activity against a broad range of cancer phenotypes.

Citric acid trisodium is a natural preservative and food acidifier. It induces apoptosis and cell cycle arrest at the G2/M phase and S phase. Citric acid trisodium causes oxidative damage to the liver by reducing antioxidant enzyme activity. It also causes nephrotoxicity in mice.

CWI1-2 is a selective inhibitor of the m6A reader protein IGF2BP2, disrupting the interaction between IGF2BP2 and m6A-modified target transcripts.

Edratide (TV 4710) is a synthetic peptide composed of 19 amino acids, based on the complementarity-determining region 1 (CDR1) of human anti-DNA antibodies, expressing mainly unique type 16/6 Id. Edratide reduces cell apoptosis and downregulates caspase-8 and caspase-3 while upregulating Bcl-xL. Edratide has potential for researching systemic lupus erythematosus (SLE).

Enpp/Carbonic anhydrase-IN-1 (compound 1e) is an effective inhibitor of Enpp and carbonic anhydrase, with IC50 values of 1.36, 1.35, 3.00, 0.88, and 1.02 μM for NPP1, NPP2, NPP3, CA-II and CA-IX respectively. Enpp/Carbonic anhydrase-IN-1 exhibits anti-proliferative activity against cancer cells while having low cytotoxicity towards normal cells. Enpp/Carbonic anhydrase-IN-1 induces apoptosis in cells.

FG-3019 (Pamrevlumab) is a recombinant humanized antibody that can bind to connective tissue growth factor (CTGF). FG-3019 can be used for the study of idiopathic pulmonary fibrosis (IPF).

Glychionide A is a flavonoid glycoside found in the roots of Glychirriza glabra. It promotes apoptosis and autophagy in PANC-1 pancreatic cancer cells. Glychionide A can be used for cancer research.

JNJ-1013 is an effective selective IRAK1 degrader, with IC50 values of 72, 443, and 1071 nM for IRAK1, IRAK4, and VHL FP respectively. JNJ-1013 induces apoptosis and increases the expression of cleaved PARP. JNJ-1013 reduces the expression of IRAK1, p-IKBα, and pSTAT3(Tyr705).

LDCA is a dual-action metabolic regulator that can inhibit LDH-A enzyme activity and stimulate apoptosis in malignant cells. LDCA can be used for research on cancer progression.

Lipid 8 is an ionizable cationic lipid molecule that can be protonated in acidic buffers to efficiently compress mRNA, forming the core of lipid nanoparticles.

Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding immunoglobulin-like lectin 8 (SIGLEC8). Lirentelimab induces apoptosis of IL-5 activated eosinophils and inhibits IL-5 mediated mast cell activation. Lirentelimab can be used for research on eosinophilic gastritis and duodenitis.

L-Theanine-d5 is the deuterated form of L-Theanine. L-Theanine (L-Glutamic Acid γ-ethyl amide) is a non-protein amino acid substance found in green tea leaves, which can block the binding of glutamate and glutamate receptors in the brain, and has neuroprotective and antioxidant activities. It can produce an anti-stress effect by inhibiting cortical neuron excitation when taken orally as L-Theanine (L-Glutamic Acid γ-ethyl amide).

Physalin A is a withanolide isolated from Physalis alkekengi var franchetii. It induces apoptosis and upregulates the expression of caspase-3 and caspase-8. Physalin A also induces autophagy, which has been found to counteract apoptosis in HT1080 cells. Physalin A has potential for researching cancer diseases.