Apoptosis

A sphingolipid

A tyrosine kinase inhibitor

Deltamethrin is a Type II synthetic pyrethroid that is used as an insecticide and acaricide worldwide.

Fedratinib hydrochloride hydrate is an effective, selective, ATP competitive and orally active JAK2 inhibitor, and the IC 50 values for both JAK2 and JAK2V617F kinases are 3nM.

Purpurin 18 is a chlorophyll-derived chlorin photosensitizer that absorbs near-infrared light in the 700–850nm range and generates reactive oxygen species (ROS) to disrupt mitochondrial membrane potential and induce apoptosis.

SIRT7 inhibitor 97491 is a potent SIRT 7 inhibitor that reduces the deacetylase activity of SIRT7 in a dose-dependent manner with an IC50 of 325 nM.

Supinoxin (RX-5902) is an orally active inhibitor of phosphorylated-p68 RNA helicase (P-p68) and a potent first-in-class anti-cancer agent. Supinoxin interacts with Y593 phosphorylated-p68 and attenuates the nuclear shuttling of β-catenin. Supinoxin induces cell apoptosis and inhibits growth of TNBC cancer cell lines with IC50s ranging from 10 nM to 20 nM.

UC2288 is a novel, cell-permeable, and orally active p21 attenuator (relatively selective activity for p21), which is synthesized based Sorafenib. UC2288 decreases p21 mRNA expression independently of p53, and attenuates p21 protein levels with minimal effect on p21 protein stability. UC2288 has no inhibition of VEGFR2 and Raf kinases even at 10 μM.

Lixisenatide acetate is a glucagon-like peptide-1 (GLP-1) receptor agonist that can be used in the treatment of type 2 diabetes mellitus (T2DM).

MSAB (methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate) is a selective Wnt/β-catenin signaling inhibitor binding to β-catenin and promoting its degradation with an EC 50 of 0.583μM.

(+)-Isomenthone is an isomer of L-Menthone, isolated from Ziziphora clinopodioidesLam. and possesses antioxidant activity.

PKCβ inhibitor 1 is a potent, ATP-competitive, and selective PKCβ inhibitor with IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2, respectively. PKCβ inhibitor 1 exhibits selectivity of more than 60-fold in favor of PKCβ2 relative to other PKC isozymes (PKCα, PKCγ, and PKCε).

3α-Hydroxy pravastatin sodium is the major metabolite of Pravastatin.

2-Methoxy-4-vinylphenol (2M4VP), a naturally Germination inhibitor, exerts potent anti-inflammatory effects.

Eribulin-d3 mesylate is a deuterium labeled Eribulin mesylate. Eribulin mesylate is a microtubule targeting agent that is used for the research of cancer.

Rapanone naturally occurring hydroxyl-benzoquinone with a privileged chelating structure, having a broad spectrum of biological actions, highlighting its anti-inflammatory, anthelmintic, and cytotoxic activities.

Echitamine chloride is the major monoterpene indole alkaloid present in Alstonia with potent anti-tumour activity. Echitamine chloride induces DNA fragmentation and cells apoptosis. Echitamine chloride inhibits pancreatic lipase with an IC50 of 10.92 μM.

Hematoporphyrin monomethyl ether, second generation of porphyrin-related photosensitizer, is characterized by its single form, high yield of singlet oxygen, high selectivity, and low toxicity, which has been widely used in the diagnosis and treatment of various tumors, including lung cancer, bladder cancer, and nevus flammeus and brain glioma.

PROTAC-O4I2 is a 2-aminothiazole derivative that selectively degrades SF3B1 and induces apoptosis in a CRBN-dependent manner (IC 50 = 0.244μM) .

Amsilarotene (TAC-101; Am 555S), an orally active synthetic retinoid, has selective affinity for retinoic acid receptor α (RAR-α) binding with Ki of 2.4, 400 nM for RAR-α and RAR-β. Amsilarotene induces the apoptotic of human gastric cancer, hepatocellular carcinoma and ovarian carcinoma cells. Amsilarotene can be used for the research of cancer.

S-Allylmercaptocysteine is a water-soluble organic sulfur compound derived from garlic extract. S-Allylmercaptocysteine has anti-tumor, antioxidant, anti-inflammatory and tissue-protective effects, and can exert biological activity by regulating ROS/MAPK, Nrf2, NF-κB and apoptosis-related signaling pathways.

Karanjin is a major active furanoflavonol constituent of Fordia cauliflora. Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Karanjin can induce cancer cell death through cell cycle arrest and enhance apoptosis.

α-solanine, a bioactive component and one of the major steroidal glycoalkaloids in potatoes, has been observed to inhibit growth and induce apoptosis in cancer cells.