KEAP1-Nrf2

CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.

Keap1-Nrf2-IN-1 is a Keap1 (Kelch-like ECH-associated protein 1)-Nrf2 (nuclear factor erythroid 2-related factor 2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein.

Nrf2-IN-1 is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2), which is developed for the research of acute myeloid leukemia (AML).

ML334 is a potent, cell-permeable activator of NRF2.

Curcumin-d6 is intended for use as an internal standard for the quantification of curcumin by GC- or LC-MS.

L-Sulforaphane is an orally active, non-specific activator of nuclear factor erythroid 2-related factor 2 (Nrf2), which functions by inhibiting the interaction between Keap1 protein and Nrf2.

Safranal is a novel, orally active monoterpene aldehyde and the main active component of saffron .

Bakkenolide B is a sesquiterpene lactone compound isolated from the leaves of Petaites japonicas , possessing anti-allergic and anti-inflammatory effects.

S-Allylmercaptocysteine is a water-soluble organic sulfur compound derived from garlic extract. S-Allylmercaptocysteine has anti-tumor, antioxidant, anti-inflammatory and tissue-protective effects, and can exert biological activity by regulating ROS/MAPK, Nrf2, NF-κB and apoptosis-related signaling pathways.

DDO-7263, a 1,2,4-Oxadiazole derivative, is a potent Nrf2-ARE activator.

(R)-5-Hydroxy-1,7-diphenyl-3-heptanone is a diarylheptanoid that can be found in Alpinia officinarum.

K67 specifically inhibits the interaction between Keap1 and S349-phosphorylated p62. K67 prevents p-p62 from blocking the binding of Keap1 and Nrf2. K67 effectively inhibits the proliferation of HCC cultures with high cellular S351-phosphorylated p62 by restoring the ubiquitination and degradation of Nrf2 driven by Keap1.

Nrf2 activator-4 (Compound 20a) is a highly potent, orally active Nrf2 activator with an EC50 of 0.63 μM. Nrf2 activator-4 suppresses reactive oxygen species against oxidative stress in microglia. Nrf2 activator-4 effectively recovers the learning and memory impairment in a scopolamine-induced mouse model.

Ezetimibe-d4 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

Nrf2 activator-2 (compound O15) is a derivative of sulforaphane, an effective Nrf2 activator with an EC50 of 2.9 μM in 293 T cells. Nrf2 activator-2 effectively inhibits the interaction between Keap1 and Nrf2, thereby showing an activating effect on Nrf2. Nrf2 activator-2 significantly reduces the level of ubiquitinated Nrf2 in cells.

Nrf2-Activator-12G (compd 12g) is an activator of Nrf2.

MIND4-17 is a potent NRF2 activator that covalently modifies a C151 residue of Keap1.

Nrf2 activator-3 is a potent Nrf2 activator.

Nrf2 activator-6, a tetrahydroisoquinoline compound, is a Nrf2 activator.

NXPZ-2 is an orally active Keap1-Nrf2 protein–protein interaction (PPI) inhibitor with a Ki value of 95 nM, EC50 value of 120 and 170 nM.

I-152 is a conjugate containing N-acetyl-cysteine (NAC) and cysteamine (MEA).

Antroquinonol ((+)-Antroquinonol), a ubiquinone derivative from the mushroom Antrodia camphorata, has hepatoprotective, anti-inflammatory, and anti-cancer effects.

Nrf2-IN-3 (Compound R16) is a Nrf2 inhibitor.

Dimetl fumarate-d2 is the deuterium labeled Dimetl fumarate.