The KEAP1-Nrf2 pathway is the major regulator of cytoprotective responses to chemical and/or oxidative stresses caused by reactive oxygen species (ROS) and electrophiles. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that binds together with small Maf proteins to the antioxidant response element (ARE) in the regulatory regions of cellular defense enzyme genes leading to the activation of a wide rang of cell defense processes; while KEAP1 (Kelch ECH associating protein 1), a negative repressor of Nrf2, is an adaptor protein for a Cul3-based ubiqutitin E3 ligase that binds to Nrf2 and promotes its degradation by the ubiquitin proteasome pathway.
- Cat.No. Product Name Information
- GN10654 (+)-Corynoline Extracted from corydalis sheareri S. Moore;Store the product in sealed,cool and dry condition
- GC31691 (+)-DHMEQ ((1R,2R,6R)-Dehydroxymethylepoxyquinomicin)
- GC15355 2-Trifluoromethyl-2'-methoxychalcone Nrf2 activator
- GC33815 4-Hydroxyphenylacetic acid
- GC31648 4-Octyl Itaconate
- GN10629 5,7-dihydroxychromone Nrf2/ARE signal activator and PPARγ agonist
- GC16120 AI-3 Nrf2/Keap1 and Keap1/Cul3 interaction inhibitor
- GN10415 Astilbin Immunosuppresive. Antiproliferative
- GC15371 Bardoxolone Once-a-day treatment for CKD
IKK inhibitor, potent antioxidant inflammation modulator
- GC34070 Brusatol (NSC 172924)
- GC35630 CDDO-EA
- GC32723 CDDO-Im (RTA-403)
- GC14787 Curcumin Tyrosinase inhibitor
- GC40226 Curcumin-d6 Curcumin-d6 is intended for use as an internal standard for the quantification of curcumin by GC- or LC-MS.
- GN10318 Danshensu Extracted from Salvia miltiorrhiza Bge. and Salvia przewalskii roots;Store the product in sealed, cool and dry condition
- GC16590 Dimethyl Fumarate nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator
- GN10531 Dimethylfraxetin Extracted from Fraxinus chinensis;Store the product in sealed, cool and dry condition.
- GN10470 Eriodictyol Extracted from eriodictyon;Store the product in sealed, cool and dry condition
- GC15605 Ezetimibe Cholesterol transport inhibitor
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