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Home >> Signaling Pathways >> Immunology/Inflammation >> KEAP1-Nrf2

KEAP1-Nrf2

The KEAP1-Nrf2 pathway is the major regulator of cytoprotective responses to chemical and/or oxidative stresses caused by reactive oxygen species (ROS) and electrophiles. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that binds together with small Maf proteins to the antioxidant response element (ARE) in the regulatory regions of cellular defense enzyme genes leading to the activation of a wide rang of cell defense processes; while KEAP1 (Kelch ECH associating protein 1), a negative repressor of Nrf2, is an adaptor protein for a Cul3-based ubiqutitin E3 ligase that binds to Nrf2 and promotes its degradation by the ubiquitin proteasome pathway.

Products for  KEAP1-Nrf2

  1. Cat.No. Product Name Information
  2. GC31691 (+)-DHMEQ

    (1R,2R,6R)-Dehydroxymethylepoxyquinomicin; (1R,2R,6R)-DHMEQ

     (+)-DHMEQ is an activator of antioxidant transcription factor Nrf2. (+)-DHMEQ Chemical Structure
  3. GC65610 (R)-5-Hydroxy-1,7-diphenyl-3-heptanone (R)-5-Hydroxy-1,7-diphenyl-3-heptanone is a diarylheptanoid that can be found in Alpinia officinarum. (R)-5-Hydroxy-1,7-diphenyl-3-heptanone Chemical Structure
  4. GC15355 2-Trifluoromethyl-2'-methoxychalcone Nrf2 activator 2-Trifluoromethyl-2'-methoxychalcone Chemical Structure
  5. GC33815 4-Hydroxyphenylacetic acid

    4-HPAA, p-HPAA, para-HPAA, p-Hydroxyphenylacetic Acid, para-Hydroxyphenylacetic Acid, NSC 25066, NSC 27460

     A phenolic acid with anti-inflammatory activity 4-Hydroxyphenylacetic acid Chemical Structure
  6. GC31648 4-Octyl Itaconate 4-Octyl Itaconate (4-OI) is a cell-permeable itaconate derivative. 4-Octyl Itaconate Chemical Structure
  7. GC16120 AI-3 Nrf2/Keap1 and Keap1/Cul3 interaction inhibitor AI-3 Chemical Structure
  8. GC71544 Antroquinonol Antroquinonol ((+)-Antroquinonol), a ubiquinone derivative from the mushroom Antrodia camphorata, has hepatoprotective, anti-inflammatory, and anti-cancer effects. Antroquinonol Chemical Structure
  9. GC34070 Brusatol

    (+)-Brusatol, NSC 172924

     Brusatol is an Nrf2 inhibitor isolated from Brucea javanica and exhibits significant tumor inhibition in multiple cancers through decreased resistance to cancer oxidative stress injury. Brusatol Chemical Structure
  10. GC35629 CDDO-dhTFEA

    RTA dh404

     CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB. CDDO-dhTFEA Chemical Structure
  11. GC35630 CDDO-EA

    CDDO ethyl amide; TP319; RTA 405

     CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator. CDDO-EA Chemical Structure
  12. GC32723 CDDO-Im (RTA-403)

    CDDO-Imidazolide, RTA 403

     CDDO-Im (RTA-403) (RTA-403) is an activator of Nrf2 and PPAR, with Kis of 232 and 344 nM for PPARα and PPARγ. CDDO-Im (RTA-403) Chemical Structure
  13. GC40226 Curcumin-d6 Curcumin-d6 is intended for use as an internal standard for the quantification of curcumin by GC- or LC-MS. Curcumin-d6 Chemical Structure
  14. GC64971 DDO-7263 DDO-7263, a 1,2,4-Oxadiazole derivative, is a potent Nrf2-ARE activator. DDO-7263 Chemical Structure
  15. GC16590 Dimethyl Fumarate

    NSC 25942, NSC 167432, transButenedioic Acid dimethyl ester

     nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator Dimethyl Fumarate Chemical Structure
  16. GC74090 Dimethyl fumarate-d2 Dimetl fumarate-d2 is the deuterium labeled Dimetl fumarate. Dimethyl fumarate-d2 Chemical Structure
  17. GC15605 Ezetimibe

    Ezetrol, SCH 58235

     Cholesterol transport inhibitor Ezetimibe Chemical Structure
  18. GC66354 Ezetimibe-d4-1

    SCH 58235-d4-1

     Ezetimibe-d4 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe-d4-1 Chemical Structure
  19. GC33092 Hesperin

    6-MSITC

     An isothiocyanate with diverse biological activities Hesperin Chemical Structure
  20. GC11302 Hinokitiol

    NSC 18804, β-Thujaplicin, 4-isopropyl Tropolone

     A tropolone with diverse biological activities Hinokitiol Chemical Structure
  21. GC71232 I-152 I-152 is a conjugate containing N-acetyl-cysteine (NAC) and cysteamine (MEA). I-152 Chemical Structure
  22. GC66004 K67 K67 specifically inhibits the interaction between Keap1 and S349-phosphorylated p62. K67 prevents p-p62 from blocking the binding of Keap1 and Nrf2. K67 effectively inhibits the proliferation of HCC cultures with high cellular S351-phosphorylated p62 by restoring the ubiquitination and degradation of Nrf2 driven by Keap1. K67 Chemical Structure
  23. GC36390 Keap1-Nrf2-IN-1 Keap1-Nrf2-IN-1 is a Keap1 (Kelch-like ECH-associated protein 1)-Nrf2 (nuclear factor erythroid 2-related factor 2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein. Keap1-Nrf2-IN-1 Chemical Structure
  24. GC31321 KI696 KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction. KI696 Chemical Structure
  25. GC34642 KI696 isomer KI696 isomer is the less active isomer of KI696. KI696 isomer Chemical Structure
  26. GC31783 Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester) Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester) (Protocatechuic acid methyl ester; Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester) Chemical Structure
  27. GC70520 MIND4-17 MIND4-17 is a potent NRF2 activator that covalently modifies a C151 residue of Keap1. MIND4-17 Chemical Structure
  28. GC38819 ML334

    LH601

     ML334 is a potent, cell-permeable activator of NRF2. ML334 Chemical Structure
  29. GC19254 ML385

    ML385 is a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor.

     ML385 Chemical Structure
  30. GC13058 NK 252

    Nrf2 activator

     NK 252 Chemical Structure
  31. GC69590 Nrf2 activator-2

    Nrf2 activator-2 (compound O15) is a derivative of sulforaphane, an effective Nrf2 activator with an EC50 of 2.9 μM in 293 T cells. Nrf2 activator-2 effectively inhibits the interaction between Keap1 and Nrf2, thereby showing an activating effect on Nrf2. Nrf2 activator-2 significantly reduces the level of ubiquitinated Nrf2 in cells.

     Nrf2 activator-2 Chemical Structure
  32. GC70868 Nrf2 activator-3 Nrf2 activator-3 is a potent Nrf2 activator. Nrf2 activator-3 Chemical Structure
  33. GC66054 Nrf2 activator-4 Nrf2 activator-4 (Compound 20a) is a highly potent, orally active Nrf2 activator with an EC50 of 0.63 μM. Nrf2 activator-4 suppresses reactive oxygen species against oxidative stress in microglia. Nrf2 activator-4 effectively recovers the learning and memory impairment in a scopolamine-induced mouse model. Nrf2 activator-4 Chemical Structure
  34. GC71031 Nrf2 activator-6 Nrf2 activator-6, a tetrahydroisoquinoline compound, is a Nrf2 activator. Nrf2 activator-6 Chemical Structure
  35. GC70411 Nrf2-Activator-12G Nrf2-Activator-12G (compd 12g) is an activator of Nrf2. Nrf2-Activator-12G Chemical Structure
  36. GC36773 Nrf2-IN-1 Nrf2-IN-1 is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2). Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML). Nrf2-IN-1 Chemical Structure
  37. GC73243 Nrf2-IN-3 Nrf2-IN-3 (Compound R16) is a Nrf2 inhibitor. Nrf2-IN-3 Chemical Structure
  38. GC71072 NXPZ-2 NXPZ-2 is an orally active Keap1-Nrf2 protein–protein interaction (PPI) inhibitor with a Ki value of 95 nM, EC50 value of 120 and 170 nM. NXPZ-2 Chemical Structure
  39. GC12821 Oltipraz

    NSC 347901, RP 35972

     Nrf2 activator;An antischistosomal agent Oltipraz Chemical Structure
  40. GC13693 Omaveloxolone (RTA-408)

    Omaveloxolone

     Omaveloxolone (RTA-408) (RTA 408) is an antioxidant inflammation modulator (AIM), which activates Nrf2 and suppresses nitric oxide (NO). Omaveloxolone (RTA-408) Chemical Structure
  41. GC15457 Pyridoxine A 4-methanol form of vitamin B6 Pyridoxine Chemical Structure
  42. GC17393 Pyridoxine HCl Pyridoxine HCl (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine HCl Chemical Structure
  43. GC63933 S-Allylmercaptocysteine S-allylmercaptocysteine, an organic sulfur compound extracted from garlic, has anti-inflammatory and anti-oxidative effects for various pulmonary diseases. S-Allylmercaptocysteine Chemical Structure
  44. GC14352 TAT 14 Nrf2 activator TAT 14 Chemical Structure
  45. GC34057 TBHQ (tert-Butylhydroquinone) TBHQ(tert-Butylhydroquinone) is a powerful phenolic antioxidant capable of reducing oxidative stress and inflammatory reactions. TBHQ (tert-Butylhydroquinone) Chemical Structure

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