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The KEAP1-Nrf2 pathway is the major regulator of cytoprotective responses to chemical and/or oxidative stresses caused by reactive oxygen species (ROS) and electrophiles. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that binds together with small Maf proteins to the antioxidant response element (ARE) in the regulatory regions of cellular defense enzyme genes leading to the activation of a wide rang of cell defense processes; while KEAP1 (Kelch ECH associating protein 1), a negative repressor of Nrf2, is an adaptor protein for a Cul3-based ubiqutitin E3 ligase that binds to Nrf2 and promotes its degradation by the ubiquitin proteasome pathway.

  1. Cat.No. Product Name Information
  2. GN10654 (+)-Corynoline Extracted from corydalis sheareri S. Moore;Store the product in sealed,cool and dry condition
  3. GC31691 (+)-DHMEQ ((1R,2R,6R)-Dehydroxymethylepoxyquinomicin)
  4. GC15355 2-Trifluoromethyl-2'-methoxychalcone Nrf2 activator
  5. GC33815 4-Hydroxyphenylacetic acid
  6. GC31648 4-Octyl Itaconate
  7. GN10629 5,7-dihydroxychromone Nrf2/ARE signal activator and PPARγ agonist
  8. GC16120 AI-3 Nrf2/Keap1 and Keap1/Cul3 interaction inhibitor
  9. GN10415 Astilbin Immunosuppresive. Antiproliferative
  10. GC15371 Bardoxolone Once-a-day treatment for CKD
  11. GC11572 Bardoxolone methyl

    IKK inhibitor, potent antioxidant inflammation modulator

  12. GC34070 Brusatol (NSC 172924)
  13. GC35630 CDDO-EA
  14. GC32723 CDDO-Im (RTA-403)
  15. GC14787 Curcumin Tyrosinase inhibitor
  16. GC40226 Curcumin-d6 Curcumin-d6 is intended for use as an internal standard for the quantification of curcumin by GC- or LC-MS.
  17. GN10318 Danshensu Extracted from Salvia miltiorrhiza Bge. and Salvia przewalskii roots;Store the product in sealed, cool and dry condition
  18. GC16590 Dimethyl Fumarate nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator
  19. GN10531 Dimethylfraxetin Extracted from Fraxinus chinensis;Store the product in sealed, cool and dry condition.
  20. GN10470 Eriodictyol Extracted from eriodictyon;Store the product in sealed, cool and dry condition
  21. GC15605 Ezetimibe Cholesterol transport inhibitor

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