KEAP1-Nrf2
The KEAP1-Nrf2 pathway is the major regulator of cytoprotective responses to chemical and/or oxidative stresses caused by reactive oxygen species (ROS) and electrophiles. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that binds together with small Maf proteins to the antioxidant response element (ARE) in the regulatory regions of cellular defense enzyme genes leading to the activation of a wide rang of cell defense processes; while KEAP1 (Kelch ECH associating protein 1), a negative repressor of Nrf2, is an adaptor protein for a Cul3-based ubiqutitin E3 ligase that binds to Nrf2 and promotes its degradation by the ubiquitin proteasome pathway.
- Cat.No. Product Name Information
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GN10654
(+)-Corynoline
Extracted from corydalis sheareri S. Moore;Store the product in sealed,cool and dry condition
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GC31691
(+)-DHMEQ
(+)-DHMEQ is an activator of antioxidant transcription factor Nrf2.
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GC65610
(R)-5-Hydroxy-1,7-diphenyl-3-heptanone
(R)-5-Hydroxy-1,7-diphenyl-3-heptanone is a diarylheptanoid that can be found in Alpinia officinarum.
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GC15355
2-Trifluoromethyl-2'-methoxychalcone
Nrf2 activator
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GC33815
4-Hydroxyphenylacetic acid
A phenolic acid with anti-inflammatory activity
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GC31648
4-Octyl Itaconate
4-Octyl Itaconate?(4-OI) is a cell-permeable itaconate derivative. Itaconate and 4-Octyl Itaconate?had similar thiol reactivity, making 4-Octyl Itaconate?a suitable itaconate surrogate to study its biological function.
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GN10629
5,7-dihydroxychromone
Nrf2/ARE signal activator and PPARγ agonist
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GC16120
AI-3
Nrf2/Keap1 and Keap1/Cul3 interaction inhibitor
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GN10415
Astilbin
Immunosuppresive. Antiproliferative
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GC15371
Bardoxolone
Once-a-day treatment for CKD
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GC11572
Bardoxolone methyl
IKK inhibitor, potent antioxidant inflammation modulator
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GC34070
Brusatol (NSC 172924)
Brusatol (NSC 172924) (NSC172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol (NSC 172924) enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol (NSC 172924) can be developed into an adjuvant chemotherapeutic agent. Brusatol (NSC 172924) increases cellular apoptosis.
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GC35629
CDDO-dhTFEA
CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB.
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GC35630
CDDO-EA
CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.
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GC32723
CDDO-Im (RTA-403)
CDDO-Im (RTA-403) (RTA-403) is an activator of Nrf2 and PPAR, with Kis of 232 and 344 nM for PPARα and PPARγ.
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GC14787
Curcumin
A tyrosinase inhibitor
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GC40226
Curcumin-d6
Curcumin-d6 is intended for use as an internal standard for the quantification of curcumin by GC- or LC-MS.
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GN10318
Danshensu
Extracted?from?Salvia miltiorrhiza Bge. and Salvia przewalskii roots;Store?the?product?in?sealed,?cool?and?dry?condition
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GC64971
DDO-7263
DDO-7263, a 1,2,4-Oxadiazole derivative, is a potent Nrf2-ARE activator.
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GC16590
Dimethyl Fumarate
nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator
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GN10531
Dimethylfraxetin
Extracted?from?Fraxinus chinensis;Store?the?product?in?sealed,?cool?and?dry?condition.
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GN10470
Eriodictyol
Extracted?from?eriodictyon;Store?the?product?in?sealed,?cool?and?dry?condition
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GC15605
Ezetimibe
Cholesterol transport inhibitor
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GC66354
Ezetimibe-d4-1
Ezetimibe-d4 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
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GN10741
Garcinone D
Extracted?from?Garcinia mangostana;Store?the?product?in?sealed,?cool?and?dry?condition
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GN10038
Ginsenoside Rh3
Extracted from Panax ginseng C. A. Mey.;Store the product in sealed,cool and dry condition
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GC33092
Hesperin
An isothiocyanate with diverse biological activities
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GC11302
Hinokitiol
A tropolone with diverse biological activities
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GC66004
K67
K67 specifically inhibits the interaction between Keap1 and S349-phosphorylated p62. K67 prevents p-p62 from blocking the binding of Keap1 and Nrf2. K67 effectively inhibits the proliferation of HCC cultures with high cellular S351-phosphorylated p62 by restoring the ubiquitination and degradation of Nrf2 driven by Keap1.
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GC36390
Keap1-Nrf2-IN-1
Keap1-Nrf2-IN-1 is a Keap1 (Kelch-like ECH-associated protein 1)-Nrf2 (nuclear factor erythroid 2-related factor 2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein.
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GC31321
KI696
KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction.
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GC34642
KI696 isomer
KI696 isomer is the less active isomer of KI696.
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GN10491
Mangiferin
Extracted from Mangifera indica L.;Suitability:Hot dilute methanol,hot dilute alcohol;Store the product in sealed,cool and dry condition
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GC31783
Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester)
Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester) (Protocatechuic acid methyl ester; Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea.
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GC38819
ML334
An inhibitor of the Nrf2-Keap1 protein-protein interaction
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GC19254
ML385
ML385 is a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor.
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GC13058
NK 252
Nrf2 activator
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GC66054
Nrf2 activator-4
Nrf2 activator-4 (Compound 20a) is a highly potent, orally active Nrf2 activator with an EC50 of 0.63 μM. Nrf2 activator-4 suppresses reactive oxygen species against oxidative stress in microglia. Nrf2 activator-4 effectively recovers the learning and memory impairment in a scopolamine-induced mouse model.
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GC36773
Nrf2-IN-1
Nrf2-IN-1 is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2). Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).
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GC12821
Oltipraz
Nrf2 activator;An antischistosomal agent
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GC13693
Omaveloxolone (RTA-408)
Omaveloxolone (RTA-408) (RTA 408) is an antioxidant inflammation modulator (AIM), which activates Nrf2 and suppresses nitric oxide (NO).
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GC15457
Pyridoxine
A 4-methanol form of vitamin B6
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GC17393
Pyridoxine HCl
Pyridoxine HCl (Pyridoxol; Vitamin B6) is a pyridine derivative.
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GC63933
S-Allylmercaptocysteine
S-allylmercaptocysteine, an organic sulfur compound extracted from garlic, has anti-inflammatory and anti-oxidative effects for various pulmonary diseases.
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GC14352
TAT 14
Nrf2 activator
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GC34057
TBHQ (tert-Butylhydroquinone)
TBHQ (tert-Butylhydroquinone) (tert-Butylhydroquinone) is a widely used Nrf2 activator, protects against Doxorubicin (DOX)-induced cardiotoxicity through activation of Nrf2. TBHQ (tert-Butylhydroquinone) (tert-Butylhydroquinone) is also an ERK activator; rescues Dehydrocorydaline (DHC)-induced cell proliferation inhibitionin melanoma.