KEAP1-Nrf2

The KEAP1-Nrf2 pathway is the major regulator of cytoprotective responses to chemical and/or oxidative stresses caused by reactive oxygen species (ROS) and electrophiles. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that binds together with small Maf proteins to the antioxidant response element (ARE) in the regulatory regions of cellular defense enzyme genes leading to the activation of a wide rang of cell defense processes; while KEAP1 (Kelch ECH associating protein 1), a negative repressor of Nrf2, is an adaptor protein for a Cul3-based ubiqutitin E3 ligase that binds to Nrf2 and promotes its degradation by the ubiquitin proteasome pathway.

Products Related to KEAP1-Nrf2(56)

GC79725 DI-1548
CAS: 2247060-97-3
Purity: >98%
DI-1548 is a potent, selective, and irreversible covalent inhibitor of DCN1 ( IC 50 = 4.6 nM).
GC79814 Isosorbide di-(methyl fumarate)
CAS: 2013542-44-2
Purity: >99.50%
Isosorbide di-(methyl fumarate) (IDMF), topical DMF derivative, is an NRF2/ARE pathway activator.
GC80416 Omaveloxolone-d 3
Purity: >98%
Omaveloxolone -d 3 (RTA 408-d 3 ) is the deuterated-labeled Omaveloxolone.
GC80873 Tovophyllin A
CAS: 40738-44-1
Purity: >98%
Tovophyllin A is an orally active xanthonoid compound.
GC81040 VVD 065
CAS: 3034876-85-9
Purity: >99.50%
VVD 065 is an orally active KEAP1 -dependent NRF2 molecular glue degrader with a KEAP1 K D of 65 nM.
GC81605 PGK1-IN-1
CAS: 3093312-81-0
Purity: >99.50%
PGK1-IN-1 (Compound 6e) is a potent and selective PGK1 inhibitor ( IC 50 : 33 nM).
GC81611 Nrf2-IN-4 hydrobromide
Purity: >99.00%
Nrf2-IN-4 (Compound PhcY) hydrobromide is a Nrf2 inhibitor.
GF11023 Hecubine
CAS: 62874-52-6
Purity: >98.00%
Hecubine is a natural aspidosperma-type alkaloid found in E. officinalis , with anti-neuroinflammation properties.

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC79725	DI-1548	2247060-97-3	>98%
GC79725	DI-1548 is a potent, selective, and irreversible covalent inhibitor of DCN1 ( IC 50 = 4.6 nM).
GC79814	Isosorbide di-(methyl fumarate)	2013542-44-2	>99.50%
GC79814	Isosorbide di-(methyl fumarate) (IDMF), topical DMF derivative, is an NRF2/ARE pathway activator.
GC80416	Omaveloxolone-d 3	-	>98%
GC80416	Omaveloxolone -d 3 (RTA 408-d 3 ) is the deuterated-labeled Omaveloxolone.
GC80873	Tovophyllin A	40738-44-1	>98%
GC80873	Tovophyllin A is an orally active xanthonoid compound.
GC81040	VVD 065	3034876-85-9	>99.50%
GC81040	VVD 065 is an orally active KEAP1 -dependent NRF2 molecular glue degrader with a KEAP1 K D of 65 nM.
GC81605	PGK1-IN-1	3093312-81-0	>99.50%
GC81605	PGK1-IN-1 (Compound 6e) is a potent and selective PGK1 inhibitor ( IC 50 : 33 nM).
GC81611	Nrf2-IN-4 hydrobromide	-	>99.00%
GC81611	Nrf2-IN-4 (Compound PhcY) hydrobromide is a Nrf2 inhibitor.
GF11023	Hecubine	62874-52-6	>98.00%
GF11023	Hecubine is a natural aspidosperma-type alkaloid found in E. officinalis , with anti-neuroinflammation properties.