Hecubine is a natural aspidosperma-type alkaloid found in E. officinalis, with anti-neuroinflammation properties [1]. Hecubine can alleviate neuroinflammation and oxidative stress by modulating the Nrf2 and TLR4 signaling pathways [2]. Hecubine has been widely used to inhibit the growth of various types of cancer cells[3].
In vitro, Hecubine pre-treatment (25μM) for 1 hour can effectively reduce the production of NO and PGE2 and the expression of iNOS and COX-2 in BV2 cells stimulated by Lipopolysaccharide (LPS) [4].
References:
[1] Gonzalez C G, Martinez J. Phytochemistry of Ervatamia coronaria Stapf.(II). Hecubine and voaphylline: two alkaloids present in leaves[J]. Rev. Cubana Farmac, 1976, 10: 45-54.
[2] Tan X, Liu H, Liang F, et al. Zebrafish as a multimodal platforms for anti-inflammatory phytomedicine discovery and translation[J]. Frontiers in Pharmacology, 2026, 17: 1775366.
[3] Naidoo C M, Naidoo Y, Dewir Y H, et al. Major bioactive alkaloids and biological activities of Tabernaemontana species (Apocynaceae)[J]. Plants, 2021, 10(2): 313.
[4] Li L, He Y L, Xu N, et al. A natural small molecule aspidosperma-type alkaloid, hecubine, as a new TREM2 activator for alleviating lipopolysaccharide-induced neuroinflammation in vitro and in vivo[J]. Redox biology, 2024, 70: 103057.