GLPBio

NF-κB

NF-κB is a family of conserved and ubiquitous transcription factors that involved in various biological processes including immunity, inflammation, cell growth, differentiation and apoptosis. It is associated with cancer, chronic inflammation and arthritis etc.

Products Related to NF-κB(336)

  • GC73301 structure
    GC733015-Aminosalicylic acid-d3
    CAS: 1309283-32-6
    Purity: >99.00%

    5-Aminosalicylic acid-d3 is the deuterium labeled 5-Aminosalicylic Acid.

  • GC73740 structure
    GC73740DCZ5418
    CAS: 2883709-99-5
    Purity: >99.00%

    DCZ5418 is an inhibitor of TRIP13.

  • GC73867 structure
    GC73867Balinatunfib (SAR-441566)
    CAS: 2248726-53-4
    Purity: >98.00%

    Balinatunfib (SAR-441566) is an orally active inhibitor of TNFR1 signaling.

  • GC74042 structure
    GC74042SpiD3
    CAS: 3033533-25-1
    Purity: >98.00%

    SpiD3 is a novel spirocyclic dimer.

  • GC74157 structure
    GC74157EN450
    CAS: 793719-01-4
    Purity: >99.00%

    EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB.

  • GC78965 structure
    GC78965ACT001 hydrochloride
    CAS: 1403357-80-1
    Purity: >98.00%

    ACT001 (Dimethylaminomicheliolide; DMAMCL) hydrochloride is an orally active, blood-brain barrier-permeable anti-inflammatory and anti-tumor agent.

  • GC78981 structure
    GC78981HBS-101
    Purity: >99.50%

    HBS-101 is a selectively, orally active, brain-penetrant, Midkine (MDK) inhibitor ( K D = 38.4 nM).

  • GC79059 structure
    GC79059SAP15 acetate
    Purity: >98.00%

    SAP15 (Synthetic anti-inflammatory peptide 15) acetate is a synthetic anti-inflammatory peptide consisting of 15 amino acids designed from human beta-defensin 3.

  • GC79389 structure
    GC79389ETI41
    CAS: 2773474-99-8
    Purity: >98.00%

    ETI41 is an orally active, selective TLR inhibitor that targets the nucleoside-binding Site I on TLR7 ( IC 50 = 0.63 μM) and TLR9 ( IC 50 = 0.16 μM), sparing surface TLRs (including TLR1/TLR2, TLR2/TLR6, TLR4 and TLR5).

  • GC79390 structure
    GC79390ETI60
    CAS: 2773475-11-7
    Purity: >99.50%

    ETI60 is an orally active, selective TLR inhibitor that targets the nucleoside-binding Site I on TLR7 ( IC 50 = 0.68 μM) and TLR9 ( IC 50 = 0.12 μM), sparing surface TLRs (including TLR1/TLR2, TLR2/TLR6, TLR4 and TLR5).

  • GC79391 structure
    GC79391MyD88-IN-3
    Purity: >99.00%

    MyD88-IN-3 is an orally active, selective MyD88 Inhibitor.

  • GC79406 structure
    GC79406SMU-Z1
    CAS: 2410782-66-8
    Purity: >99.00%

    SMU-Z1 is a TLR1/2 heterodimer agonist with an EC 50 of 4.88 nM.

  • GC79407 structure
    GC79407Anti-Mouse CD20 Antibody (18B12)
    Purity: >99.00%

    Anti-Mouse CD20 Antibody (18B12) is a B cell depleting agent that targets mouse CD20.

  • GC79451 structure
    GC79451JP-11646
    CAS: 1902983-63-4
    Purity: >98.50%

    JP-11646 is a pan-PIM inhibitor with increased potency against PIM2 ( IC 50 = 0.5 nM).

  • GC79486 structure
    GC79486Bacoside A (mixture)
    Purity: >98.00%

    Bacoside A (mixture) is a mixture composed of Bacoside A3, Bacopaside II, Bacopaside X and Bacopasaponin C.

  • GC79676 structure
    GC79676PTPRO-IN-1
    Purity: >98.00%

    PTPRO-IN-1 is a selective, orally active PTPRO inhibitor with an IC 50 of 0.16 μM.

  • GC79724 structure
    GC79724CHI3L1-IN-5
    CAS: 2249043-42-1
    Purity: >98.50%

    CHI3L1-IN-5 (Compound Z17) is a highly selective CHI3L1 inhibitor with a K D value of 6 μM.

  • GC79803 structure
    GC79803Paeonolsilate sodium
    CAS: 827610-11-7
    Purity: >98.00%

    Paeonolsilate (sodium) can inhibit ox-LDL-induced macrophage foam cell formation and inflammation in atherosclerosis.

  • GC79804 structure
    GC79804Cupabimod
    CAS: 297774-48-2
    Purity: >91.00%

    Cupabimod is a decoy oligodeoxynucleotide for transcription factor NF-κB.

  • GC79805 structure
    GC798056-Methoxymellein
    CAS: 13410-15-6
    Purity: >99.00%

    6-Methoxymellein, a phytoalexin, is a NF-κB inhibitor.

  • GC79806 structure
    GC79806TKL002
    CAS: 3098518-95-4
    Purity: >98.00%

    TKL002 is a blood-brain barrier-permeable inhibitor of the CTH/H 2 S/NF-κB/EMT signaling axis.

  • GC79807 structure
    GC79807RP-182 acetate
    Purity: >98.50%

    RP-182 acetate is a synthetic immunomodulatory peptide that exerts anti-tumor effects by targeting the mannose receptor CD206 ( K d = 8 μM) on the surface of tumor-associated macrophages (TAMs).

  • GC79808 structure
    GC79808SAR113945 monopotassium
    CAS: 899418-65-6
    Purity: >98.00%

    SAR113945 monopotassium is a highly selective IKK-β inhibitor with an IC 50 value of 0.4 nM.

  • GC79811 structure
    GC79811Tat-IKIP (46-60) TFA
    Purity: >99.50%

    Tat-IKIP (46-60) TFA is the trifluoroacetic acid of Tat-IKIP (46-60).