JAK/STAT Signaling

Epertinib hydrochloride (S-22611 hydrochloride) is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4, with IC50s of 1.48 nM, 7.15 nM and 2.49 nM, respectively. Epertinib hydrochloride shows potent antitumor activity.

Golotimod hydrochloride (SCV 07 hydrochloride), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function.

A fourth-generation and non-covalent EGFR tyrosine kinase inhibitor

AS2863619 is an orally administered small molecule inhibitor of cyclin-dependent kinase (CDK) 8 and 19 with IC 50 of 0.6099nM and 4.277nM, respectively.

AS2863619 free base enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases.

Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain.

Reticuline shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways.

Ascochlorin is an isoprenoid antibiotic and antiviral that has diverse effects on mammalian cells.

VX-509 is a selective inhibitor of Janus kinase 3 (JAK3) with a Ki value of 2.5 nM in enzyme assays and an IC50 value of 50-170 nM in cellular assays dependent on JAK3 activity with no measurable activity against other JAK isotypes.

An inhibitor of EGFR

FMS-like tyrosine kinase 3 (FLT3) and Janus kinase 2 (JAK2) are tyrosine kinases that mediate cytokine signaling and are frequently mutated in cancers, particularly acute myeloid leukemia.

Tephrosin (synthetic) is a natural rotenoid which has potent antitumor activities. Tephrosin (synthetic) induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors.

Brassinin (BSN) is a phytoalexin isolated from B.

Delphinidin (chloride) is one of the common monomeric forms of anthocyanins, isolated from berries and red wine.

Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer.

MM-206 is an inhibitor of STAT3 (IC50 = 1.16 μM in an SPR-based competitive assay).

Niclosamide is an anthelmintic drug approved by the US Food and Drug Administration (FDA) for treating intestinal infections of tapeworms .

O-Desmethyl gefitinib is the major metabolite of gefitinib in human plasma, formed by the cytochrome P450 isoform CYP2D6.

A JAK2 inhibitor

C-X-C chemokine receptor type 4 (CXCR4) is a receptor for the stromal cell-derived factor-1 which is designated as chemokine ligand 12 (CXCL12).

An internal standard for the quantification of pimozide

2-NP is a cell-penetrating, selective signal transduction and transcription activator 1 (STAT1) transcription enhancer.

A dual inhibitor of IDO1 and STAT3 activation

An internal standard for the quantification of nifuroxazide