ERK

Endothelin-1 (1-31) (Human) TFA is an effective vasoconstrictor and hypertensive agent. It is derived from the selective hydrolysis of big ET-1 by chymase.

RLX-33 is an effective and selective relaxin family peptide 3 (RXFP3) antagonist with blood-brain barrier permeability. It also blocks the phosphorylation of ERK1/2 induced by relaxin 3, with IC50 values for RXFP3, ERK1, and ERK2 phosphorylation being 2.36 μM, 7.82 μM, and 13.86 μM respectively. RLX-33 can block the increase in food intake induced by the RXFP3 selective agonist R3/I5 in rats. RLX-33 can be used for research on metabolic syndrome.

Salbutamol (Albuterol) is a short-acting beta-2 adrenergic receptor agonist with oral activity.

MK2-IN-5 (Hsp25 kinase inhibitor) acetate is a Mk2 pseudosubstrate (Ki= 8 μM).

AZA197 is a selective small molecule inhibitor of Cdc42.

(R)-VX-11e (Compound 1) is an ERK2 inhibitor.

I-287 is a orally active selective PAR2 inhibitor that acting as a negative allosteric regulator on Gαq and Gα12/13 activity and their downstream effectors.

MY-673 is a colchicine binding site inhibitor (CBSI), that inhibits tubulin polymerization.

SHR2415 is a highly potent, selective and orally active ERK1/2 inhibitor.

(S)-BAY 2965501 is the left-handed isomer of BAY 2965501.

MEK-IN-6 (Example 69) is a MEK inhibitor.

ERK1/2 inhibitor 9 (Probe 1) is a covalent ERK1/2 inhibitor.

LUNA18 is an orally-available cyclic peptide KRAS and ERK inhibitor.

ERK5-IN-5 (compound 4a) is an ERK5 kinase inhibitor with anticancer activity.

RMC-4998 is an orally active inhibitor targeting the active or GTP-bound state of the KRASG12C mutant.

Serum tmic factor acetate (Tmulin acetate) is the acetate salt form of Serum tmic factor.

NN3201 is a c-Kit -targeting antibody-drug conjugate ( ADC ) with high affinity ( K D = 0.19 pM).

Peptide R54 acetate (Pep R54 acetate) is a CXCR4 antagonist.

BBO-11818 is an orally active, highly selective (relative to NRAS and HRAS ), non-covalent pan- KRAS inhibitor ( IC 50 =28-120 nM).

RMC-4998 TFA is an orally active inhibitor targeting the active or GTP-bound state of the KRAS G12C mutant.

RM-046 is an orally active, selective ternary complex inhibitor of KRAS Q61H (active form).

SHY-867 is a pan RAS inhibitor.

SHY-855 is a pan RAS inhibitor.

RNK08954 is an orally active KRAS G12D inhibitor with a K d of 0.0395 nM.