ERK

FZ1 peptide is a cyclic heptapeptide and also an integrin αvβ3 agonist.

Glutathione trisulfide TFA (GSSSG TFA) is an orally active, blood-brain barrier permeable neuroprotective agent.

UE01 is an orally active, selective small-molecule modulator targeting both ULK1/ERK1/2.

Sialorphin TFA is a neutral endopeptidase ( NEP ) and aminopeptidase N ( APN ) inhibitor that responds to androgen signals.

Hericene A is an orally active aromatic hericene derivative.

RANKL-IN-1 formate is a selective receptor activator of nuclear factor-κB ligand inhibitor ligand ( RANKL ) inhibitor with a K D value of 7.6 μM.

Lipoteichoic acid is a teichoic acid predominantly located in the cell walls of Gram-positive bacteria, widely involved in stimulating immune responses and cellular signaling pathways.

Astragaloside IV, an active component isolated from Astragalus membranaceus, can protect the myocardium against ischemia/reperfusion injury and Inhibits HAdV-3 replication and reduces HAdV-3-induced apoptosis.

Honokiol is a natural bisphenol chemical with multiple biological activities. It targets multiple signaling molecules and has effective antioxidant, anti-inflammatory, anti-angiogenic and anti-cancer activities. It also has broad-spectrum antibacterial and anti-human immunodeficiency virus (HIV) activities.

VRT752271 (BVD-523; VRT752271) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC50 of <0.3 nM against ERK2. VRT752271 (BVD-523; VRT752271) inhibits the phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) in an A375 melanoma cell line.

FR 180204 is a selective ERK inhibitor with IC 50 values of 0.51μM and 0.33μM for ERK1 and ERK2, respectively.