PKA

Metadoxine blocks adipocyte differentiation in association with inhibition of the protein kinase A-cAMP response element binding protein (PKA-CREB) pathway.

A biflavonoid with diverse biological activities

Bucladesine calcium salt salt (Dibutyryl-cAMP calcium salt;DC2797 calcium salt) is a cell-permeable cyclic AMP (cAMP) analog and selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP.

Kemptide (Phospho-Ser5) is a phosphate acceptor peptide that serves as a specific substrate for cAMP-dependent protein kinase (PKA).

PKA Inhibitor (5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM.

Rp-8-CPT-Cyclic AMP (sodium salt), a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II.

A PKA inhibitor

PKA signaling activator; promotes osteogenesis from hMSCs

Inhibits PKA/AKAP interactions; cell permeable

Negative control for st-Ht31

AKAP disruptor; selectively binds PKA-RII and blocks its interaction with AKAP; cell permeable

AKAP disruptor; selectively binds PKA-RI with high affinity and blocks its interaction with AKAP; cell permeable

A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases.

PKA inhibitor fragment (6-22) amide TFA is a synthetic peptide inhibitor of cAMP-dependent protein kinase A (PKA) with K i =1.7 nM.

Sp-cAMPS, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II.

PKI 14-22 amide,myristoylated TFA is a potent cAMP-dependent PKA inhibitor. PKI 14-22 amide,myristoylated TFA reduces the IgG-mediated phagocytic response and also inhibits neutrophil adhesion.

Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 ?M and 4.5 ?M, respectively) antagonist.

8-Chloro-cAMP is a cAMP analogue that induces growth arrest, and modulates cAMP-dependent PKA activity. 8-Chloro-cAMP has anticancer activity.

Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei.

DS89002333 is an orally effective and potent inhibitor of PRKACA with an IC50 value of 0.3 nM. It exhibits good anti-tumor activity in a xenograft model derived from FL-HCC patients expressing the DNAJB1-PRKACA fusion gene. DS89002333 can be used for research on fibrolamellar hepatocellular carcinoma (FL-HCC).

PKI (14-24)amide TFA is an effective inhibitor of PKA. In cell cytosol, PKI (14-24)amide strongly inhibits the activity of cyclic AMP-dependent protein kinase.

PKA RII peptide TFA is a PKA substrate that, after being phosphorylated at the serine residue, can be used for the detection of calcineurin activity.

CREBtide TFA is a CREB (cAMP response element binding protein)-like peptide.

BLU0588 is an orally active, potent and selective PRKACA (protein kinase cAMP-activated catalytic subunit alpha) kinase inhibitor, with an IC50 of 1 nM and dissociation constant (Kd) of 4 nM.