GLPBio

Factor Xa

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Factor Xa is a trypsin-like serine protease that catalyzes the cleavage of peptide bonds on the carboxyl side (P’1) of a basic amino acid residue with a preference to cleave peptide bonds of carboxyl function provided by an argininyl residue. Factor Xa plays an essential role in the coagulation cascade catalyzing the conversion of prothrombin to thrombin on surface of vascular cells to link the extrinsic and intrinsic pathways, in which it forms the Ca2+- and phospholipid-dependent prothrombinase complex with cofactor V/Va on activated platelets, monocytes or endothelial cells. Moreover, factor Xa has been found to mediate the stimulation of lymphocyte proliferation, induce the mitogenesis of endothelial and smooth muscle cells, and trigger acute inflammatory responses in vivo.

Products Related to Factor Xa(59)

  • GC71122 structure
    GC71122GalNAc unconjugated/naked Fitusiran sodium
    Purity: >97.00%

    GalNAc unconjugated/naked Fitusiran (sodium), an small interfering RNA without GalNAc conjugation, specifically targets antithrombin (AT) messenger RNA to lower production of AT in the liver.

  • GC71242 structure
    GC71242ARC19499 sodium
    Purity: >93.00%

    ARC19499 sodium is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway.

  • GC71270 structure
    GC71270CH3OCO-D-CHA-Gly-Arg-pNA acetate
    CAS: 80895-10-9
    Purity: >98.50%

    CH3OCO-D-CHA-Gly-Arg-pNA acetate is a chromogenic substrate for factor Xa.

  • GC71531 structure
    GC71531Ciraparantag acetate
    CAS: 1644388-83-9
    Purity: >98.00%

    Ciraparantag acetate is a small-molecule, synthetic, water-soluble broad-spectrum anticoagulant reversal agent. Ciraparantag binds to and neutralizes the anticoagulant activity of unfractionated heparin, low molecular weight heparin, fondaparinux, as well as direct factor Xa inhibitors and direct thrombin inhibitors through non-covalent hydrogen bonding and charge-charge interactions, thereby restoring hemostatic function without exhibiting significant procoagulant effects.

  • GC71580 structure
    GC71580Otamixaban hydrochloride
    CAS: 409081-12-5

    Otamixaban (FXV673) is a potent, selective, rapid-acting, competitive, and reversible fXa inhibitor (Ki=0.5 nM) that effectively inhibits both free and prothrombinase-bound fXa.

  • GC71583 structure
    GC71583Dechloro Rivaroxaban
    CAS: 1415566-28-7
    Purity: >99.00%

    Dechloro Rivaroxaban is a highly selective, orally active inhibitor of Factor Xa.

  • GC72438 structure
    GC72438Osocimab
    CAS: 2056878-75-0
    Purity: 95.00%

    Osocimab (BAY 1213790), an anti-FXIa antibody (Ki=2.4 nM; EC50=0.2 nM).

  • GC72527 structure
    GC72527S-(-)-Warfarin
    CAS: 5543-57-7
  • GC72772 structure
    GC72772Eribaxaban
    CAS: 536748-46-6
    Purity: >98.00%

    Eribaxaban (PD-0348292) is an orally active and selective FXa inhibitor with a Ki value of 0.32 nM.

  • GC73668 structure
    GC73668Frunexian
    CAS: 1803270-60-1
    Purity: >97.00%

    Frunexian (EP-7041) is a selective and potent inhibitor of coagulation factor XI/activated factor XI, targeting to factor XIa.

  • GC74033 structure
    GC74033FXIIa-IN-4
    Purity: >98.00%

    FXIIa-IN-4 (compound 22) is a potent, selective human FXIIa inhibitor with the IC50 of 0.032 μM, 0.30 μM, ＞50 μM for FXIIa, thrombin and FXIa, respectively.