Obesity, Appetite Control & Diabetes

Ghrelin is an endogenous gastrointestinal hormone and neuropeptide that binds to the growth hormone (GH) secretagogue receptor (GHS-R).

GLP-1 (7-36) amide is a peptide hormone released from intestinal L-cells upon nutrient consumption.

Glucagon-like peptide-1 (GLP-1) (7-37) is an endogenous incretin hormone and truncated form of GLP-1 (1-37) that is produced via cleavage of preproglucagon in the pancreas and intestine.

Glucagon-like peptide-2 (GLP-2) is an endogenous peptide hormone formed in L cells of the small and large intestine by cleavage of proglucagon in response to nutrient ingestion.

An inactive control for glucagon receptor antagonist I

Glucocerebrosides are formed by the tethering of glucose to a ceramide by glucosylceramide synthase.

Glyburide is a sulfonylurea and an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.3 nM).

Glycolithocholic Acid, a conjugate of secondary bile acids and glycine, is an endogenous metabolic product within the body.

Glycolithocholic acid is a glycine conjugate of lithocholic acid, a bile acid.

Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor found predominantly in the liver that is involved in the regulation of lipid homeostasis.

Fasudil (HA-1077; AT877) dihydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. HA-1077 (hydrochloride) is also a potent Ca2+ channel antagonist and vasodilator.

Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor that stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis.

Lactisole is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit.

Lithocholic acid 3-sulfate is a metabolite of the secondary bile acid lithocholic acid.

MHY908 is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ that increases transcriptional activity of PPARα and PPARγ in a luciferase reporter assay in AC2F rat liver cells when used at a concentration of 5 μM.

ML-262 is an inhibitor of hepatic lipid droplet formation (IC50 = 6.4 nM in murine AML-12 cells), which is associated with non-alcoholic fatty liver disease.

MLS-0322825 Cmpd 23 is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A.

Agmatine is a natural polyamine formed by the enzymatic decarboxylation of arginine.

ND-336 is a selective inhibitor of the gelatinases matrix metalloproteinase-2 (MMP-2) and MMP-9, as well as MMP-14 (Kis = 85, 150, and 120 nM, respectively).

Neuromedin S is a neuropeptide expressed in brain.

N-Oleoyl Leucine is a fatty acid–amino acid conjugate (FAAA) that belongs to the family of N-acyl amino acids.

In humans, two forms of diacylglycerol lipase, DAGLα and DAGLβ, generate the endocannabinoid 2-arachidonoyl glycerol by attacking DAG at the sn-1 position.

Obestatin is a 23-amino acid peptide hormone that is formed by cleavage of the ghrelin and obestatin prepropeptide.

Orlistat degradation product is a degradation product of the digestive lipase inhibitor orlistat.