Antioxidants

3',4',7-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor of Cot (Tpl2/MAP3K8) and MKK4. 3',4',7-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities.

Naturally occurring phytochemicals such as turmeric (curcumin) have been found to inhibit the growth of tumor cells.

CMS121 is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor.

Curcuminoids are natural and synthetic analogs of curcumin, a natural polyphenol with modulating effects in inflammation, cancer, and immunity.

Aspalatone is an anti-platelet aggregator (IC50 = 180 μM, in vitro) that prolongs bleeding time significantly in a rodent model of thromboembolism.

Orsellinic acid is a fungal metabolite and benzoic acid derivative with antioxidant and neuroprotective activities.

Decursinol angelate is a pyranocoumarin that has been found in the Korean medicinal herb A.

Vitamin E is a well known antioxidant that exists in eight natural forms: four tocopherols (α, β, δ, and γ) and four tocotrienols (α, β, δ, and γ).

Glutathione (GSH) serves as a nucleophilic co-substrate to glutathione transferase in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of hydroperoxides.

Melatonin is a neurotransmitter widely distributed in eukaryotes and is closely linked to circadean rhythms in mammals including humans.

Hecogenin is a natural steroid sapogenin with diverse biological activities that was originally isolated from A.

Ocimene is a monoterpene found in a variety of plants, including Cannabis, and is a volatile compound involved in plant-plant signaling and plant defense against pests.

Terpinolene is a monoterpene found in the essential oils of various plants, including C.

β-Myrcene is a terpene that has been found in Cannabis and has antioxidative properties.

Anacardic acid triene is a polyunsaturated form of anacardic acid that has been found in cashew nut shell liquid.

Molecules having vitamin E antioxidant activity include four tocopherols (α, β, γ, δ) and four tocotrienols (α, β, γ, δ).

(±)-α-Tocopherol is a synthetic vitamin E, with antioxidation effect.

The early stage of atherosclerosis is characterized by the aggregation of foam cells, so called a fatty streak, in the inner arterial wall.

(±)13-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL.

(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP) is a stilbene derivative with antioxidant and anticancer activities.

1,3,7-Trimethyluric acid is a methyl derivative of uric acid and a product of C-8 oxidation of caffeine by cytochrome P450 enzymes.

10-methyl-9-(phenoxycarbonyl) Acridinium is an acridinium ester that produces fluorescent 10-methyl-9-acridone upon oxidation with hydrogen peroxide, persulfates, and other oxidants in alkaline conditions.

2-Thiobarbituric acid is a colorimetric reagent commonly used in the detection of malondialdehyde (MDA), a marker of lipid peroxidation.

Resveratrol is a potent phenolic antioxidant found in natural sources that has antiproliferative activity.