mTOR

YJ1206 TFA is an orally active selective CDK12 / CDK13 PROTAC degrader.

Lipoteichoic acid is a teichoic acid predominantly located in the cell walls of Gram-positive bacteria, widely involved in stimulating immune responses and cellular signaling pathways.

Salidroside is a tyrosol glycoside primarily found in the roots of Rhodiola species, exhibiting a wide range of biological and pharmacological properties, including anti-cancer, antioxidant, anti-aging, anti-diabetic, anti-hypertensive, anti-inflammatory, and immunomodulatory effects.

Dihydromyricetin is a natural flavanonol isolated from A. grossedentata and H. dulcis that has antioxidant, antiproliferative, anti-apoptotic, and anti-alcohol intoxication properties.

MTOR inhibitor

Ridaforolimus (Deforolimus, MK-8669) is an orally active and selective Mammalian Target of Rapamycin (mTOR) inhibitor (IC₅₀=0.2nM), Ridaforolimus acts by inhibiting the mTOR signaling pathway, thereby affecting the phosphorylation of downstream effector proteins such as S6 and 4E-BP1.

MTOR inhibitor,ATP-competitive and selective

Torin 2 is an orally active mTOR inhibitor (EC 50 =0.25nM).

OSI-027 is a selective small molecule oral inhibitor that can simultaneously inhibit the kinase activities of mTORC1 and mTORC2, with IC 50 values of 22nM and 65nM, respectively.

WYE-125132 (WYE-132) (WYE-125132) is a highly potent, ATP-competitive, and specific mTOR kinase inhibitor (IC50: 0.19±0.07 nM; >5,000-fold selective versus PI3Ks). WYE-125132 (WYE-132) (WYE-125132) inhibits mTORC1 and mTORC2.

GDC-0980 (RG7422) (GDC-0980; GNE 390; RG 7422) is a selective, potent, orally bioavailable Class I PI3 kinase and mTOR kinase (TORC1/2) inhibitor with IC50s of 5 nM/27 nM/7 nM/14 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ, and with aKiof 17 nM for mTOR.