E3 Ligase Ligand-Linker Conjugate
Read More about this categoryShow Less
E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc.MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.
Products Related to E3 Ligase Ligand-Linker Conjugate(201)
- GC50663Thalidomide 4'-ether-alkylC3-acidCAS: 2169266-64-0Purity: >95.00%
Thalidomide 4'-ether-alkylC3-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- GC50666Pomalidomide 4'-PEG1-amineCAS: 2154342-56-8Purity: >95.00%
Pomalidomide 4'-PEG1-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- GC50673Thalidomide 4'-ether-alkylC4-acidCAS: 2169266-67-3Purity: >95.00%
Thalidomide 4'-ether-alkylC4-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- GC50683Thalidomide 4'-ether-alkylC5-acidCAS: 2087490-48-8Purity: >95.00%
Thalidomide 4'-ether-alkylC5-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- GC50688Thalidomide 4'-ether-alkylC6-acidCAS: 2169266-69-5Purity: >95.00%
Thalidomide 4'-ether-alkylC6-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- GC50691Thalidomide 4'-ether-alkylC7-acidCAS: 2169266-70-8Purity: >95.00%
Thalidomide 4'-ether-alkylC7-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- GC50692Pomalidomide 4'-alkylC8-amineCAS: 2446474-06-0Purity: >95.00%
Pomalidomide 4'-alkylC8-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- GC50693Pomalidomide 4'-PEG3-amineCAS: 2446474-09-3Purity: >95.00%
Pomalidomide-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 5) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
- GC50713Pomalidomide 4'-PEG5-acidCAS: 2139348-63-1Purity: >95.00%
Pomalidomide 4'-PEG5-acid (Pomalidomide-PEG5-CO2H) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 5-unit PEG linker used in PROTAC technology.
- GC61199Pomalidomide-C7-COOHCAS: 2225940-51-0Purity: >98.00%
Pomalidomide-C7-COOH is a synthesized E3 ligase cereblon ligand-linker conjugate. Pomalidomide-C7-COOH is an intermediate for the synthesis of PROTAC BCL-XL degraders.
- GC61201Pomalidomide-PEG3-C2-NH2 TFACAS: 2414913-97-4Purity: >99.00%
Pomalidomide-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
- GC61202Pomalidomide-PEG4-azideCAS: 2271036-47-4Purity: >98%
Pomalidomide-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
- GC61329Thalidomide-O-amido-C3-COOHCAS: 2308035-51-8Purity: >99.00%
Thalidomide-O-amido-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- GC61330Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2CAS: 2435572-49-7Purity: >96.00%
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
- GC61449Pomalidomide-amido-C3-COOHCAS: 2162120-77-4Purity: >98.00%
Pomalidomide-amido-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
- GC61617Pomalidomide-PEG2-azideCAS: 2267306-14-7Purity: >99.00%
Pomalidomide-PEG2-azide is a synthetic E3 ligase ligand-linker conjugate that includes a Pomalidomide-based cereblon ligand and a 2-unit PEG linker used in proteolysis targeting chimeras (PROTAC) technology. Pomalidomide-PEG2-azide is a click chemistry reagent containing an azide group that can react with alkynyl-containing molecules via a Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction.
- GC61618Pomalidomide-PEG3-azideCAS: 2267306-15-8Purity: >98.00%
Pomalidomide-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
- GC61774(S,R,S)-AHPC-PEG5-BocPurity: >95.00%
(S,R,S)-AHPC-PEG5-Boc is a E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for Cdc20 degrader CP5V.
- GC62126Glutarimide-Isoindolinone-NH-PEG2-COOHPurity: >98.50%
Glutarimide-Isoindolinone-NH-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a cereblon ligand and a linker used in PROTAC technology.
- GC62131Pomalidomide 4’-PEG2-azideCAS: 2271036-45-2Purity: >99.00%
Pomalidomide 4’-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
- GC62148(S,R,S)-AHPC-amido-C5-acidCAS: 2162120-87-6Purity: >97.00%
(S,R,S)-AHPC-amido-C5-acid incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design XY028-133.
- GC62154N-Descyclopropanecarbaldehyde OlaparibCAS: 763111-47-3Purity: >99.00%
N-Descyclopropanecarbaldehyde Olaparib is an analogue of Olaparib containing DOTA moiety. N-Descyclopropanecarbaldehyde Olaparib is a CRBN-based ligand for synthesizing novel dual EGFR and PARP PROTAC, DP-C-4. N-Descyclopropanecarbaldehyde Olaparib can be radiolabeled F-18 or fluorophore for positron emission tomography (PET) or optical imaging in several types of tumor.
- GC62176Thalidomide-PEG3-COOHPurity: >98.00%
Thalidomide-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- GC62177Thalidomide-PEG4-COOHPurity: >95.00%
Thalidomide-PEG4-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC50663 | Thalidomide 4'-ether-alkylC3-acid | 2169266-64-0 | >95.00% | |
Thalidomide 4'-ether-alkylC3-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. | ||||
| GC50666 | Pomalidomide 4'-PEG1-amine | 2154342-56-8 | >95.00% | |
Pomalidomide 4'-PEG1-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. | ||||
| GC50673 | Thalidomide 4'-ether-alkylC4-acid | 2169266-67-3 | >95.00% | |
Thalidomide 4'-ether-alkylC4-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. | ||||
| GC50683 | Thalidomide 4'-ether-alkylC5-acid | 2087490-48-8 | >95.00% | |
Thalidomide 4'-ether-alkylC5-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. | ||||
| GC50688 | Thalidomide 4'-ether-alkylC6-acid | 2169266-69-5 | >95.00% | |
Thalidomide 4'-ether-alkylC6-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. | ||||
| GC50691 | Thalidomide 4'-ether-alkylC7-acid | 2169266-70-8 | >95.00% | |
Thalidomide 4'-ether-alkylC7-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. | ||||
| GC50692 | Pomalidomide 4'-alkylC8-amine | 2446474-06-0 | >95.00% | |
Pomalidomide 4'-alkylC8-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. | ||||
| GC50693 | Pomalidomide 4'-PEG3-amine | 2446474-09-3 | >95.00% | |
Pomalidomide-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 5) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. | ||||
| GC50713 | Pomalidomide 4'-PEG5-acid | 2139348-63-1 | >95.00% | |
Pomalidomide 4'-PEG5-acid (Pomalidomide-PEG5-CO2H) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 5-unit PEG linker used in PROTAC technology. | ||||
| GC61199 | Pomalidomide-C7-COOH | 2225940-51-0 | >98.00% | |
Pomalidomide-C7-COOH is a synthesized E3 ligase cereblon ligand-linker conjugate. Pomalidomide-C7-COOH is an intermediate for the synthesis of PROTAC BCL-XL degraders. | ||||
| GC61201 | Pomalidomide-PEG3-C2-NH2 TFA | 2414913-97-4 | >99.00% | |
Pomalidomide-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. | ||||
| GC61202 | Pomalidomide-PEG4-azide | 2271036-47-4 | >98% | |
Pomalidomide-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. | ||||
| GC61329 | Thalidomide-O-amido-C3-COOH | 2308035-51-8 | >99.00% | |
Thalidomide-O-amido-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. | ||||
| GC61330 | Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 | 2435572-49-7 | >96.00% | |
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. | ||||
| GC61449 | Pomalidomide-amido-C3-COOH | 2162120-77-4 | >98.00% | |
Pomalidomide-amido-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. | ||||
| GC61617 | Pomalidomide-PEG2-azide | 2267306-14-7 | >99.00% | |
Pomalidomide-PEG2-azide is a synthetic E3 ligase ligand-linker conjugate that includes a Pomalidomide-based cereblon ligand and a 2-unit PEG linker used in proteolysis targeting chimeras (PROTAC) technology. Pomalidomide-PEG2-azide is a click chemistry reagent containing an azide group that can react with alkynyl-containing molecules via a Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. | ||||
| GC61618 | Pomalidomide-PEG3-azide | 2267306-15-8 | >98.00% | |
Pomalidomide-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. | ||||
| GC61774 | (S,R,S)-AHPC-PEG5-Boc | - | >95.00% | |
(S,R,S)-AHPC-PEG5-Boc is a E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for Cdc20 degrader CP5V. | ||||
| GC62126 | Glutarimide-Isoindolinone-NH-PEG2-COOH | - | >98.50% | |
Glutarimide-Isoindolinone-NH-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a cereblon ligand and a linker used in PROTAC technology. | ||||
| GC62131 | Pomalidomide 4’-PEG2-azide | 2271036-45-2 | >99.00% | |
Pomalidomide 4’-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. | ||||
| GC62148 | (S,R,S)-AHPC-amido-C5-acid | 2162120-87-6 | >97.00% | |
(S,R,S)-AHPC-amido-C5-acid incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design XY028-133. | ||||
| GC62154 | N-Descyclopropanecarbaldehyde Olaparib | 763111-47-3 | >99.00% | |
N-Descyclopropanecarbaldehyde Olaparib is an analogue of Olaparib containing DOTA moiety. N-Descyclopropanecarbaldehyde Olaparib is a CRBN-based ligand for synthesizing novel dual EGFR and PARP PROTAC, DP-C-4. N-Descyclopropanecarbaldehyde Olaparib can be radiolabeled F-18 or fluorophore for positron emission tomography (PET) or optical imaging in several types of tumor. | ||||
| GC62176 | Thalidomide-PEG3-COOH | - | >98.00% | |
Thalidomide-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. | ||||
| GC62177 | Thalidomide-PEG4-COOH | - | >95.00% | |
Thalidomide-PEG4-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. | ||||