GLPBio

E3 Ligase Ligand-Linker Conjugate

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E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc.MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.

Products Related to E3 Ligase Ligand-Linker Conjugate(201)

  • GC62183 structure
    GC62183(S,R,S)-AHPC-O-Ph-PEG1-NH2
    CAS: 2361117-24-8
    Purity: >96.00%

    (S,R,S)-AHPC-O-Ph-PEG1-NH2 (VH032-O-Ph-PEG1-NH2) is E3 ligase ligand-linker conjugate and incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-O-Ph-PEG1-NH2 is used in PROTAC EED degrader-1. PROTAC EED degrader-1 is a PROTAC targeting EED with a pKD of 9.02.

  • GC62204 structure
    GC62204Thalidomide-NH-PEG4-COOH
    CAS: 2412056-48-3
    Purity: >98.50%

    Thalidomide-NH-PEG4-COOH is an E3 ligase ligand-linker conjugate which can be used for synthesizing dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP.

  • GC62226 structure
    GC62226Thalidomide-PEG5-COOH
    Purity: >98.00%

    Thalidomide-PEG5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

  • GC62232 structure
    GC62232Glutarimide-Isoindolinone-NH-PEG4-COOH
    Purity: >99.50%

    Glutarimide-Isoindolinone-NH-PEG4-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a cereblon ligand and a linker used in PROTAC technology.

  • GC62585 structure
    GC62585(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2
    CAS: 2409538-69-6
    Purity: >95.00%

    (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 can be used in PROTAC BRD4 Degrader-5 and PROTAC BRD4 Degrader-5-CO-PEG3-N3.

  • GC62595 structure
    GC62595Thalidomide-O-amido-C3-PEG3-C1-NH2
    CAS: 1799711-29-7
    Purity: >99.00%

    Thalidomide-O-amido-C3-PEG3-C1-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

  • GC62681 structure
    GC62681Thalidomide-NH-PEG3-COOH
    CAS: 2375283-62-6
    Purity: >98.00%

    Thalidomide-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

  • GC62684 structure
    GC62684(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH
    CAS: 2086301-47-3
    Purity: >99.00%

    (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH) is a E3 ligase ligand-linker conjugate that contains on one end a VHL ligand. (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH is used in PROTAC technology.

  • GC62713 structure
    GC62713Thalidomide-Propargyne-PEG2-COOH
    Purity: >99.00%

    Thalidomide-Propargyne-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

  • GC62714 structure
    GC62714Thalidomide-Propargyne-PEG3-COOH
    Purity: >98.00%

    Thalidomide-Propargyne-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

  • GC62718 structure
    GC62718Thalidomide-Propargyne-PEG1-COOH
    Purity: >99.00%

    Thalidomide-Propargyne-PEG1-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

  • GC62722 structure
    GC62722Thalidomide-NH-C4-NH-Boc
    CAS: 2093388-52-2
    Purity: >99.50%

    Thalidomide-NH-C4-NH-Boc (compound 15) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

  • GC62991 structure
    GC62991Glutarimide-Isoindolinone-NH-PEG3-COOH
    Purity: >99.00%

    Glutarimide-Isoindolinone-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a cereblon ligand and a linker used in PROTAC technology.

  • GC63149 structure
    GC63149Pom-8PEG
    CAS: 2488761-03-9
    Purity: >98%

    Pom-8PEG, an E3 ligase ligand-linker conjugate, incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and an 8-unit PEG linker. Pom-8PEG can be used in the synthesis of PROTAC, such as IDO1 PROTAC degrader.

  • GC63219 structure
    GC63219Thalidomide-O-PEG4-amine TFA
    Purity: >98%

    Thalidomide-O-PEG4-amine TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

  • GC63220 structure
    GC63220Thalidomide-piperazine-Boc
    CAS: 2222114-64-7
    Purity: >99.50%

    Thalidomide-piperazine-Boc is an intermediate that can be used in the synthesis of B-cell lymphoma 6 protein (BCL6) PROTAC.

  • GC63221 structure
    GC63221Thalidomide-Piperazine-PEG1-NH2 diTFA
    Purity: >99.50%

    Thalidomide-Piperazine-PEG1-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

  • GC63222 structure
    GC63222Thalidomide-Piperazine-PEG2-NH2 diTFA
    Purity: >99.50%

    Thalidomide-Piperazine-PEG2-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

  • GC63223 structure
    GC63223Thalidomide-Piperazine-PEG3-COOH
    Purity: >99.50%

    Thalidomide-Piperazine-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

  • GC63224 structure
    GC63224Thalidomide-Piperazine-PEG3-NH2
    CAS: 2357113-68-7
    Purity: >98%

    Thalidomide-Piperazine-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

  • GC63225 structure
    GC63225Thalidomide-Piperazine-Piperidine
    CAS: 2229716-11-2
    Purity: >98%

    Thalidomide-Piperazine-Piperidine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

  • GC63474 structure
    GC63474Lenalidomide-C5-amido-Boc
    CAS: 2138441-25-3
    Purity: >95.00%

    Lenalidomide-C5-amido-Boc is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-amido-Boc can be connected to the ligand for protein by a linker to form PROTAC.

  • GC63494 structure
    GC63494(S,R,S)-AHPC-Me-C5-COOH
    CAS: 2229976-21-8
    Purity: >98%

    (S,R,S)-AHPC-Me-C5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C5-COOH can be used in PROTAC DT2216.

  • GC63529 structure
    GC63529Thalidomide-O-PEG4-NHS ester
    CAS: 2411681-88-2
    Purity: >98%

    Thalidomide-O-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.