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Home >> Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

E3 Ligase Ligand-Linker Conjugate

E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc.MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.

Targets for  E3 Ligase Ligand-Linker Conjugate

Products for  E3 Ligase Ligand-Linker Conjugate

  1. Cat.No. Product Name Information
  2. GC69944 (S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-Me-C10-NH2 TFA

    (S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-Me-C10-NH2 TFA is a synthetic E3 ligase ligand-linker conjugate containing the (S,R,S)-AHPC ligand, which can be used in PROTAC research.

     (S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-Me-C10-NH2 TFA Chemical Structure
  3. GC69945 (S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-PEG3-NH2 TFA

    "(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-PEG3-NH2 TFA" is a synthetic E3 ligase ligand-linker conjugate, which includes a ligand based on (S,R,S)-AHPC and a three-unit PEG linker."

     (S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-PEG3-NH2 TFA Chemical Structure
  4. GC62148 (S,R,S)-AHPC-amido-C5-acid (S,R,S)-AHPC-amido-C5-acid incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design XY028-133. (S,R,S)-AHPC-amido-C5-acid Chemical Structure
  5. GC69946 (S,R,S)-AHPC-amido-C7-acid

    (S,R,S)-AHPC-amido-C7-acid contains a VHL ligand for recruiting E3 ubiquitin ligases and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used for designing PROTACs.

     (S,R,S)-AHPC-amido-C7-acid Chemical Structure
  6. GC62684 (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH) is a E3 ligase ligand-linker conjugate that contains on one end a VHL ligand. (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH is used in PROTAC technology. (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH Chemical Structure
  7. GC69947 (S,R,S)-AHPC-C10-NHBoc

    (S,R,S)-AHPC-C10-NHBoc is a synthetic E3 ligase ligand-linker conjugate, containing a VHL ligand based on (S,R,S)-AHPC and one linker. It can be used to synthesize targeted PROTACs for BET.

     (S,R,S)-AHPC-C10-NHBoc Chemical Structure
  8. GC69743 (S,R,S)-AHPC-C4-NH2 hydrochloride

    (S,R,S)-AHPC-C4-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate, containing a VHL ligand based on (S,R,S)-AHPC and one linker. It is used for the synthesis of targeted PROTACs for EED.

     (S,R,S)-AHPC-C4-NH2 hydrochloride Chemical Structure
  9. GC65133 (S,R,S)-AHPC-C5-COOH (S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized?E3 ligase ligand-linker conjugate, contains the VH032 VHL-based ligand and a linker to form PROTACs. VH-032 is a selective and potent inhibitor of VHL/HIF-1α interaction with a Kd of 185 nM, has the potential for the study of anemia and ischemic diseases. (S,R,S)-AHPC-C5-COOH Chemical Structure
  10. GC69948 (S,R,S)-AHPC-CO-C9-acid

    "(S,R,S)-AHPC-CO-C9-acid" is a ligand-linker complex of E3 ligase, which can be attached to the ligand of a protein to form a PROTAC."

     (S,R,S)-AHPC-CO-C9-acid Chemical Structure
  11. GC67831 (S,R,S)-AHPC-Me-C10-Br (S,R,S)-AHPC-Me-C10-Br Chemical Structure
  12. GC64371 (S,R,S)-AHPC-Me-C10-NH2 (S,R,S)-AHPC-Me-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432. (S,R,S)-AHPC-Me-C10-NH2 Chemical Structure
  13. GC63494 (S,R,S)-AHPC-Me-C5-COOH (S,R,S)-AHPC-Me-C5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C5-COOH can be used in PROTAC DT2216. (S,R,S)-AHPC-Me-C5-COOH Chemical Structure
  14. GC67729 (S,R,S)-AHPC-Me-C6-NH2 (S,R,S)-AHPC-Me-C6-NH2 Chemical Structure
  15. GC63561 (S,R,S)-AHPC-Me-C7 ester (S,R,S)-AHPC-Me-C7 ester is a E3 ligase ligand-linker conjugate used to synthesise BCL-XL PROTAC degraders. (S,R,S)-AHPC-Me-C7 ester Chemical Structure
  16. GC62585 (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 can be used in PROTAC BRD4 Degrader-5 and PROTAC BRD4 Degrader-5-CO-PEG3-N3. (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 Chemical Structure
  17. GC62183 (S,R,S)-AHPC-O-Ph-PEG1-NH2 (S,R,S)-AHPC-O-Ph-PEG1-NH2 (VH032-O-Ph-PEG1-NH2) is E3 ligase ligand-linker conjugate and incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-O-Ph-PEG1-NH2 is used in PROTAC EED degrader-1. PROTAC EED degrader-1 is a PROTAC targeting EED with a pKD of 9.02. (S,R,S)-AHPC-O-Ph-PEG1-NH2 Chemical Structure
  18. GC61774 (S,R,S)-AHPC-PEG5-Boc (S,R,S)-AHPC-PEG5-Boc is a E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for Cdc20 degrader CP5V. (S,R,S)-AHPC-PEG5-Boc Chemical Structure
  19. GC50466 A 410099.1, amine A 410099.1, amine is afunctionalizedIAP ligand and can be used for the synthesis of PROTACs, such as PROTACs targeting BTK (PROTACs 4 and 5). A 410099.1, amine Chemical Structure
  20. GC35931 E3 ligase Ligand 17 E3 ligase Ligand 17 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a PEG linker used in PROTAC technology. E3 ligase Ligand 17 Chemical Structure
  21. GC34565 E3 ligase Ligand 8 hydrochloride E3 ligase Ligand 8 hydrochloride Chemical Structure
  22. GC34566 E3 ligase Ligand 9 E3 ligase Ligand 9 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 9 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins. E3 ligase Ligand 9 Chemical Structure
  23. GC32779 E3 Ligase Ligand-Linker Conjugates 1 E3 Ligase Ligand-Linker Conjugates 1 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. E3 Ligase Ligand-Linker Conjugates 1 Chemical Structure
  24. GC32986 E3 ligase Ligand-Linker Conjugates 11 E3 ligase Ligand-Linker Conjugates 11 is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. E3 ligase Ligand-Linker Conjugates 11 is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays. E3 ligase Ligand-Linker Conjugates 11 Chemical Structure
  25. GC33000 E3 ligase Ligand-Linker Conjugates 12 E3 ligase Ligand-Linker Conjugates 12 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. E3 ligase Ligand-Linker Conjugates 12 Chemical Structure
  26. GC32888 E3 ligase Ligand-Linker Conjugates 13 E3 ligase Ligand-Linker Conjugates 13 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in PROTAC technology. E3 ligase Ligand-Linker Conjugates 13 Chemical Structure
  27. GC32761 E3 ligase Ligand-Linker Conjugates 14 E3 ligase Ligand-Linker Conjugates 14 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. E3 ligase Ligand-Linker Conjugates 14 Chemical Structure
  28. GC34365 E3 ligase Ligand-Linker Conjugates 15 E3 ligase Ligand-Linker Conjugates 15 Chemical Structure
  29. GC30064 E3 ligase Ligand-Linker Conjugates 16 E3 ligase Ligand-Linker Conjugates 16 (Cereblon Ligand-Linker Conjugates 6 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. E3 ligase Ligand-Linker Conjugates 16 Chemical Structure
  30. GC30050 E3 ligase Ligand-Linker Conjugates 17 E3 ligase Ligand-Linker Conjugates 17 (Cereblon Ligand -Linker Conjugates 2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. E3 ligase Ligand-Linker Conjugates 17 Chemical Structure
  31. GC30105 E3 ligase Ligand-Linker Conjugates 18 E3 ligase Ligand-Linker Conjugates 18 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. E3 ligase Ligand-Linker Conjugates 18 Chemical Structure
  32. GC33129 E3 Ligase Ligand-Linker Conjugates 19 E3 Ligase Ligand-Linker Conjugates 19 (Cereblon Ligand-Linker Conjugates 6), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs. E3 Ligase Ligand-Linker Conjugates 19 Chemical Structure
  33. GC32871 E3 Ligase Ligand-Linker Conjugates 2 E3 Ligase Ligand-Linker Conjugates 2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. E3 Ligase Ligand-Linker Conjugates 2 Chemical Structure
  34. GC33390 E3 Ligase Ligand-Linker Conjugates 20 E3 Ligase Ligand-Linker Conjugates 20 (Cereblon Ligand-Linker Conjugates 2), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs. E3 Ligase Ligand-Linker Conjugates 20 Chemical Structure
  35. GC33103 E3 Ligase Ligand-Linker Conjugates 21 E3 Ligase Ligand-Linker Conjugates 21 (Cereblon Ligand-Linker Conjugates 3) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. E3 Ligase Ligand-Linker Conjugates 21 Chemical Structure
  36. GC32903 E3 Ligase Ligand-Linker Conjugates 22 E3 Ligase Ligand-Linker Conjugates 22 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. E3 Ligase Ligand-Linker Conjugates 22 Chemical Structure
  37. GC34334 E3 Ligase Ligand-Linker Conjugates 23 TFA E3 Ligase Ligand-Linker Conjugates 23 TFA Chemical Structure
  38. GC33473 E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate (Cereblon Ligand-Linker Conjugates 11 TFA), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs. E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate Chemical Structure
  39. GC33110 E3 ligase Ligand-Linker Conjugates 3 E3 ligase Ligand-Linker Conjugates 3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 1-unit PEG linker used in PROTAC technology. E3 ligase Ligand-Linker Conjugates 3 Chemical Structure
  40. GC35935 E3 ligase Ligand-Linker Conjugates 30 E3 ligase Ligand-Linker Conjugates 30 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. E3 ligase Ligand-Linker Conjugates 30 Chemical Structure
  41. GC35936 E3 ligase Ligand-Linker Conjugates 30 TFA E3 ligase Ligand-Linker Conjugates 30 TFA Chemical Structure
  42. GC35937 E3 ligase Ligand-Linker Conjugates 33 E3 ligase Ligand-Linker Conjugates 33 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 33 can be used to design SNIPERs. E3 ligase Ligand-Linker Conjugates 33 Chemical Structure
  43. GC35938 E3 ligase Ligand-Linker Conjugates 33 Hydrochloride E3 ligase Ligand-Linker Conjugates 33 Hydrochloride incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 33 Hydrochloride can be used to design SNIPERs. E3 ligase Ligand-Linker Conjugates 33 Hydrochloride Chemical Structure
  44. GC35939 E3 ligase Ligand-Linker Conjugates 34 E3 ligase Ligand-Linker Conjugates 34 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 34 can be used to design SNIPERs. E3 ligase Ligand-Linker Conjugates 34 Chemical Structure
  45. GC35940 E3 ligase Ligand-Linker Conjugates 34 Hydrochloride E3 ligase Ligand-Linker Conjugates 34 Hydrochloride incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 34 Hydrochloride can be used to design SNIPERs. E3 ligase Ligand-Linker Conjugates 34 Hydrochloride Chemical Structure
  46. GC35941 E3 ligase Ligand-Linker Conjugates 35 Hydrochlride E3 ligase Ligand-Linker Conjugates 35 Hydrochlride Chemical Structure
  47. GC35942 E3 ligase Ligand-Linker Conjugates 36 E3 ligase Ligand-Linker Conjugates 36 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 36 can be used to design SNIPERs. E3 ligase Ligand-Linker Conjugates 36 Chemical Structure
  48. GC35943 E3 ligase Ligand-Linker Conjugates 37 E3 ligase Ligand-Linker Conjugates 37 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 37 can be used to design SNIPERs. E3 ligase Ligand-Linker Conjugates 37 Chemical Structure
  49. GC35944 E3 ligase Ligand-Linker Conjugates 37 Hydrochloride E3 ligase Ligand-Linker Conjugates 37 Hydrochloride Chemical Structure
  50. GC35945 E3 ligase Ligand-Linker Conjugates 38 E3 ligase Ligand-Linker Conjugates 38 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 38 can be used to design SNIPERs. E3 ligase Ligand-Linker Conjugates 38 Chemical Structure
  51. GC35946 E3 ligase Ligand-Linker Conjugates 39 E3 ligase Ligand-Linker Conjugates 39 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 39 can be used to design SNIPERs. E3 ligase Ligand-Linker Conjugates 39 Chemical Structure
  52. GC30071 E3 ligase Ligand-Linker Conjugates 4 E3 ligase Ligand-Linker Conjugates 4 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. E3 ligase Ligand-Linker Conjugates 4 Chemical Structure
  53. GC35947 E3 ligase Ligand-Linker Conjugates 40 E3 ligase Ligand-Linker Conjugates 40 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 40 can be used to design SNIPERs. E3 ligase Ligand-Linker Conjugates 40 Chemical Structure
  54. GC35948 E3 ligase Ligand-Linker Conjugates 41 E3 ligase Ligand-Linker Conjugates 41 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 41 can be used to design SNIPERs. E3 ligase Ligand-Linker Conjugates 41 Chemical Structure
  55. GC35949 E3 ligase Ligand-Linker Conjugates 42 E3 ligase Ligand-Linker Conjugates 42 Chemical Structure
  56. GC35950 E3 ligase Ligand-Linker Conjugates 43 E3 ligase Ligand-Linker Conjugates 43 Chemical Structure
  57. GC35951 E3 ligase Ligand-Linker Conjugates 44 E3 ligase Ligand-Linker Conjugates 44 Chemical Structure
  58. GC35952 E3 ligase Ligand-Linker Conjugates 45 E3 ligase Ligand-Linker Conjugates 45 Chemical Structure
  59. GC35953 E3 ligase Ligand-Linker Conjugates 46 E3 ligase Ligand-Linker Conjugates 46 Chemical Structure
  60. GC35954 E3 ligase Ligand-Linker Conjugates 47 E3 ligase Ligand-Linker Conjugates 47 Chemical Structure
  61. GC35955 E3 ligase Ligand-Linker Conjugates 48 E3 ligase Ligand-Linker Conjugates 48 Chemical Structure
  62. GC35956 E3 ligase Ligand-Linker Conjugates 49 E3 ligase Ligand-Linker Conjugates 49 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. E3 ligase Ligand-Linker Conjugates 49 Chemical Structure
  63. GC32813 E3 ligase Ligand-Linker Conjugates 5 E3 ligase Ligand-Linker Conjugates 5 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. E3 ligase Ligand-Linker Conjugates 5 Chemical Structure
  64. GC33113 E3 ligase Ligand-Linker Conjugates 5 Free Base E3 ligase Ligand-Linker Conjugates 5 Free Base is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. E3 ligase Ligand-Linker Conjugates 5 Free Base Chemical Structure
  65. GC35957 E3 ligase Ligand-Linker Conjugates 50 E3 ligase Ligand-Linker Conjugates 50 Chemical Structure
  66. GC35958 E3 ligase Ligand-Linker Conjugates 51 E3 ligase Ligand-Linker Conjugates 51 Chemical Structure
  67. GC32839 E3 ligase Ligand-Linker Conjugates 6 E3 ligase Ligand-Linker Conjugates 6 (VH032-PEG2-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs. E3 ligase Ligand-Linker Conjugates 6 Chemical Structure
  68. GC33111 E3 ligase Ligand-Linker Conjugates 6 Free Base E3 ligase Ligand-Linker Conjugates 6 Free Base (VH032-PEG2-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs. E3 ligase Ligand-Linker Conjugates 6 Free Base Chemical Structure
  69. GC32866 E3 ligase Ligand-Linker Conjugates 7 E3 ligase Ligand-Linker Conjugates 7 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. E3 ligase Ligand-Linker Conjugates 7 Chemical Structure
  70. GC32994 E3 ligase Ligand-Linker Conjugates 7 Free Base E3 ligase Ligand-Linker Conjugates 7 Free Base is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. E3 ligase Ligand-Linker Conjugates 7 Free Base Chemical Structure
  71. GC62126 Glutarimide-Isoindolinone-NH-PEG2-COOH Glutarimide-Isoindolinone-NH-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a cereblon ligand and a linker used in PROTAC technology. Glutarimide-Isoindolinone-NH-PEG2-COOH Chemical Structure
  72. GC62991 Glutarimide-Isoindolinone-NH-PEG3-COOH Glutarimide-Isoindolinone-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a cereblon ligand and a linker used in PROTAC technology. Glutarimide-Isoindolinone-NH-PEG3-COOH Chemical Structure
  73. GC62232 Glutarimide-Isoindolinone-NH-PEG4-COOH Glutarimide-Isoindolinone-NH-PEG4-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a cereblon ligand and a linker used in PROTAC technology. Glutarimide-Isoindolinone-NH-PEG4-COOH Chemical Structure
  74. GC63474 Lenalidomide-C5-amido-Boc Lenalidomide-C5-amido-Boc is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-amido-Boc can be connected to the ligand for protein by a linker to form PROTAC. Lenalidomide-C5-amido-Boc Chemical Structure
  75. GC64104 Lenalidomide-C5-NH2 TFA Lenalidomide-C5-NH2 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs, such as MDM2 PROTAC degrader. Lenalidomide-C5-NH2 TFA Chemical Structure
  76. GC64867 Lenalidomide-PEG1-azide Lenalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Lenalidomide-PEG1-azide incorporates the Lenalidomide based cereblon ligand and a linker.?Lenalidomide-PEG1-azide?can be used to design a PROTAC BRD4 Degrader-2. Lenalidomide-PEG1-azide Chemical Structure
  77. GC38808 Lenalidomide-propargyl-C2-NH2 hydrochloride Lenalidomide-propargyl-C2-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. Lenalidomide-propargyl-C2-NH2 hydrochloride can be used to design the PROTAC MD-224. Lenalidomide-propargyl-C2-NH2 hydrochloride Chemical Structure
  78. GC62154 N-Descyclopropanecarbaldehyde Olaparib N-Descyclopropanecarbaldehyde Olaparib is an analogue of Olaparib containing DOTA moiety. N-Descyclopropanecarbaldehyde Olaparib is a CRBN-based ligand for synthesizing novel dual EGFR and PARP PROTAC, DP-C-4. N-Descyclopropanecarbaldehyde Olaparib can be radiolabeled F-18 or fluorophore for positron emission tomography (PET) or optical imaging in several types of tumor. N-Descyclopropanecarbaldehyde Olaparib Chemical Structure
  79. GC68431 NJH-2-030 NJH-2-030 Chemical Structure
  80. GC67991 Nutlin-C1-amido-PEG4-C2-N3 Nutlin-C1-amido-PEG4-C2-N3 Chemical Structure
  81. GC63149 Pom-8PEG Pom-8PEG, an E3 ligase ligand-linker conjugate, incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and an 8-unit PEG linker. Pom-8PEG can be used in the synthesis of PROTAC, such as IDO1 PROTAC degrader. Pom-8PEG Chemical Structure
  82. GC62131 Pomalidomide 4’-PEG2-azide Pomalidomide 4’-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. Pomalidomide 4’-PEG2-azide Chemical Structure
  83. GC50692 Pomalidomide 4'-alkylC8-amine Pomalidomide 4'-alkylC8-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Pomalidomide 4'-alkylC8-amine Chemical Structure
  84. GC50666 Pomalidomide 4'-PEG1-amine Pomalidomide 4'-PEG1-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Pomalidomide 4'-PEG1-amine Chemical Structure
  85. GC50545 Pomalidomide 4'-PEG3-acid Pomalidomide 4'-PEG3-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. Pomalidomide 4'-PEG3-acid Chemical Structure
  86. GC50693 Pomalidomide 4'-PEG3-amine Pomalidomide-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 5) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. Pomalidomide 4'-PEG3-amine Chemical Structure
  87. GC50713 Pomalidomide 4'-PEG5-acid Pomalidomide 4'-PEG5-acid (Pomalidomide-PEG5-CO2H) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 5-unit PEG linker used in PROTAC technology. Pomalidomide 4'-PEG5-acid Chemical Structure
  88. GC69726 Pomalidomide-5'-PEG8-C2-COOH

    Pomalidomide-5'-PEG8-C2-COOH is an E3 ligase ligand-linker conjugate composed of Pomalidomide and a linker. It can be used to synthesize PROTACs.

     Pomalidomide-5'-PEG8-C2-COOH Chemical Structure
  89. GC39171 Pomalidomide-amido-C1-Br Pomalidomide-amido-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker. Pomalidomide-amido-C1-Br can be used to design a B-Raf PROTAC degrader PROTAC B-Raf degrader 1. PROTAC B-Raf degrader 1 has anti-cancer activity. Pomalidomide-amido-C1-Br Chemical Structure
  90. GC61449 Pomalidomide-amido-C3-COOH Pomalidomide-amido-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. Pomalidomide-amido-C3-COOH Chemical Structure
  91. GC68156 Pomalidomide-amino-PEG3-NH2 hydrochloride Pomalidomide-amino-PEG3-NH2 hydrochloride Chemical Structure
  92. GC63811 Pomalidomide-amino-PEG4-NH2 hydrochloride Pomalidomide-amino-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. Pomalidomide-amino-PEG4-NH2 hydrochloride Chemical Structure
  93. GC68157 Pomalidomide-amino-PEG5-NH2 hydrochloride Pomalidomide-amino-PEG5-NH2 hydrochloride Chemical Structure
  94. GC65092 Pomalidomide-C12-NH2 hydrochloride Pomalidomide-C12-NH2 hydrochloride is the E3 ligase ligand-linker conjugate of PROTAC KRAS G12C degrader-1. PROTAC KRAS G12C degrader-1 is a Cereblon-based KRASG12C degrader. Pomalidomide-C12-NH2 hydrochloride Chemical Structure
  95. GC38381 Pomalidomide-C2-NH2 hydrochloride Pomalidomide-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. Pomalidomide-C2-NH2 hydrochloride Chemical Structure
  96. GC61199 Pomalidomide-C7-COOH Pomalidomide-C7-COOH is a synthesized E3 ligase cereblon ligand-linker conjugate. Pomalidomide-C7-COOH is an intermediate for the synthesis of PROTAC BCL-XL degraders. Pomalidomide-C7-COOH Chemical Structure
  97. GC64769 Pomalidomide-PEG1-azide Pomalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Pomalidomide-PEG1-azide incorporates the Pomalidomide based cereblon ligand and a linker.?Pomalidomide-PEG1-azide?can be used to design a?PROTAC BRD4 Degrader-1. Pomalidomide-PEG1-azide Chemical Structure
  98. GC69727 Pomalidomide-PEG1-NH2 hydrochloride

    Pomalidomide-PEG1-NH2 hydrochloride is a crosslinking E3 ligase ligand conjugate composed of the E3 ligase ligand pomalidomide and a PEGylated crosslinker with an end amine group, which is used to react with carboxylic acid groups on the target ligand.

     Pomalidomide-PEG1-NH2 hydrochloride Chemical Structure
  99. GC61617 Pomalidomide-PEG2-azide Pomalidomide-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology. Pomalidomide-PEG2-azide Chemical Structure
  100. GC61618 Pomalidomide-PEG3-azide Pomalidomide-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. Pomalidomide-PEG3-azide Chemical Structure
  101. GC61201 Pomalidomide-PEG3-C2-NH2 TFA Pomalidomide-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. Pomalidomide-PEG3-C2-NH2 TFA Chemical Structure

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