GLPBio

E3 Ligase Ligand-Linker Conjugate

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E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc.MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.

Products Related to E3 Ligase Ligand-Linker Conjugate(201)

  • GC63561 structure
    GC63561(S,R,S)-AHPC-Me-C7 ester
    CAS: 2639528-48-4
    Purity: >98%

    (S,R,S)-AHPC-Me-C7 ester is a E3 ligase ligand-linker conjugate used to synthesise BCL-XL PROTAC degraders.

  • GC63811 structure
    GC63811Pomalidomide-amino-PEG4-NH2 hydrochloride
    CAS: 2331259-45-9
    Purity: >99.00%

    Pomalidomide-amino-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.

  • GC63831 structure
    GC63831Thalidomide-4-O-C10-COOH
    CAS: 2379870-45-6
    Purity: >98.00%

    Thalidomide-4-O-C10-COOH is a E3 ligase ligand-linker conjugate that can be used in the synthesis of PROTACs.

  • GC64104 structure
    GC64104Lenalidomide-C5-NH2 TFA
    Purity: >98.00%

    Lenalidomide-C5-NH2 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs, such as MDM2 PROTAC degrader.

  • GC64371 structure
    GC64371(S,R,S)-AHPC-Me-C10-NH2
    CAS: 2376139-52-3
    Purity: >98%

    (S,R,S)-AHPC-Me-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432.

  • GC64640 structure
    GC64640Thalidomide-Piperazine-Piperidine hydrochloride
    CAS: 2599846-44-1
    Purity: >98%

    Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-Piperazine-Piperidine hydrochloride incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

  • GC64769 structure
    GC64769Pomalidomide-PEG1-azide
    CAS: 2133360-04-8
    Purity: >95.00%

    Pomalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Pomalidomide-PEG1-azide incorporates the Pomalidomide based cereblon ligand and a linker.?Pomalidomide-PEG1-azide?can be used to design a?PROTAC BRD4 Degrader-1.

  • GC64790 structure
    GC64790Thalidomide-O-PEG4-amine hydrochloride
    Purity: >96.00%

    Thalidomide-O-PEG4-amine hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

  • GC64867 structure
    GC64867Lenalidomide-PEG1-azide
    CAS: 2185795-67-7
    Purity: >95.00%

    Lenalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Lenalidomide-PEG1-azide incorporates the Lenalidomide based cereblon ligand and a linker.?Lenalidomide-PEG1-azide?can be used to design a PROTAC BRD4 Degrader-2.

  • GC65092 structure
    GC65092Pomalidomide-C12-NH2 hydrochloride
    Purity: >96.00%

    Pomalidomide-C12-NH2 hydrochloride is the E3 ligase ligand-linker conjugate of PROTAC KRAS G12C degrader-1. PROTAC KRAS G12C degrader-1 is a Cereblon-based KRASG12C degrader.

  • GC65133 structure
    GC65133(S,R,S)-AHPC-C5-COOH
    CAS: 2267282-19-7
    Purity: >98%

    (S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized?E3 ligase ligand-linker conjugate, contains the VH032 VHL-based ligand and a linker to form PROTACs. VH-032 is a selective and potent inhibitor of VHL/HIF-1α interaction with a Kd of 185 nM, has the potential for the study of anemia and ischemic diseases.

  • GC65196 structure
    GC65196Pomalidomide-PEG6-butyl iodide
    CAS: 1835705-74-2
    Purity: >98.00%

    Pomalidomide-PEG6-butyl iodide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 6-unit PEG linker used in PROTAC technology.

  • GC66314 structure
    GC66314Thalidomide-O-C6-NH2 TFA
    CAS: 1957235-99-2
    Purity: >98%

    Thalidomide-O-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13 (HY-114421), a degrader of FKBP12F36V and BET.

  • GC66635 structure
    GC66635Thalidomide-O-PEG4-Boc
    CAS: 2411681-87-1
    Purity: >98%

    Thalidomide-O-PEG4-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

  • GC66637 structure
    GC66637Thalidomide-O-PEG4-amine
    CAS: 2401832-00-4
    Purity: >98%

    Thalidomide-O-PEG4-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

  • GC66642 structure
    GC66642Thalidomide-O-PEG4-azide
    CAS: 2380318-57-8
    Purity: >98%

    Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

  • GC66644 structure
    GC66644Thalidomide-PEG2-C2-NH2
    CAS: 2093416-32-9
    Purity: >98%

    Thalidomide-PEG2-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.

  • GC67327 structure
    GC67327Thalidomide-NH-C6-NH2
    CAS: 2093386-50-4
    Purity: >98%

    Thalidomide-NH-C6-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

  • GC67478 structure
    GC67478Thalidomide-O-C6-NH2
    CAS: 1957235-98-1
    Purity: >98%

    Thalidomide-O-C6-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

  • GC67499 structure
    GC67499Thalidomide-O-amido-C8-NH2 hydrochloride
    CAS: 2415263-07-7
    Purity: >98%

    Thalidomide-O-amido-C8-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.

  • GC67504 structure
    GC67504Thalidomide-NH-C2-PEG3-OH
    CAS: 2140807-23-2
    Purity: >98%

    Thalidomide-NH-C2-PEG3-OH is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739.

  • GC67505 structure
    GC67505Thalidomide-NH-PEG4-Ms
    CAS: 2140807-24-3
    Purity: >98%

    Thalidomide-NH-PEG4-Ms is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739.

  • GC67506 structure
    GC67506Thalidomide-NH-PEG8-Ts
    CAS: 2488761-07-3
    Purity: >98%

    Thalidomide-NH-PEG8-Ts is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 8-unit PEG linker used in PROTAC technology, such as IDO1 PROTAC degrader .

  • GC67507 structure
    GC67507Thalidomide-PEG4-NH2 hydrochloride
    CAS: 2387510-82-7
    Purity: >98%

    Thalidomide-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.