Acyltransferase
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DGAT (acyl-CoA: diacylglycerol acyltransferase) is a transmembrane enzyme that acts in the final and committed step of triacylglycerides (TAGs) synthesis, and it has been proposed to be the rate-limiting enzyme in plant storage lipid accumulation. DGAT catalyzes the acylation of sn-1,2-diacylglycerol (DAG) at the sn-3 position using an acyl-CoA substrate. DGAT has been proposed to be the rate-limiting enzyme in plant storage lipid accumulation. DGAT is considered a key enzyme for biotechnological purposes; it might be utilized to increase oil content in oleaginous plant species.
DGAT1 and DGAT2 are two of the enzymes that are responsible for the main part of TAG synthesis in most organisms, and they have been studied in many eukaryotic organisms.
Products Related to Acyltransferase(69)
- GC61888Pactimibe sulfateCAS: 608510-47-0Purity: >98.00%
Pactimibe sulfate (CS-505) is a dual ACAT1/2 inhibitor with IC50s of 4.9 μM and 3.0 μM, respectively.
- GC64687BMS-963272CAS: 1441057-15-3Purity: >99.00%
BMS-963272 is a potent, selective MGAT2 inhibitor (IC50 = 7.1 nM) for the treatment of metabolic disorders.
- GC65200Nevanimibe hydrochlorideCAS: 133825-81-7Purity: >98.00%
Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer.
- GC71495LecimibideCAS: 130804-35-2
Lecimibide (DuP 128) is a potent and specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor for antihyperlipidemia research.
- GC73626PF-07202954CAS: 2639372-47-5Purity: >97.00%
PF-07202954 is a weakly basic DGAT2 inhibitor with an IC50 of 10 nM for human DGAT2.
- GC74100EflucimibeCAS: 202340-45-2Purity: >99.50%
Eflucimibe (F 12511) is a new acyl-coenzyme A cholesterol O-acyltransferase (ACAT) inhibitor.
- GC79554PF-06427878CAS: 1809064-23-0Purity: >98%
PF-06427878 is an orally active, selective liver-targeted diacylglycerol acyltransferase 2 ( DGAT2 ) inhibitor with IC 50 s of 99 nM and 202 nM for human and rat DGAT2, respectively.
- GC79555Ent-Calquiquelignan ECAS: 1292294-31-5Purity: >98%
Ent-Calquiquelignan E (Compound 8) is a flavonoid lignan compound.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC50570 | ST 045849 | 442665-87-4 | >98.50% | |
ST 045849 is an inhibitor of O-GlcNAc transferase (OGT), with an IC 50 value of 53μM. | ||||
| GC52256 | CAY10794 | 1231243-91-6 | >98.00% | |
An inhibitor of DGAT-1 | ||||
| GC52290 | (R)-HTS-3 | 2771208-83-2 | >98.00% | |
An inhibitor of LPCAT3 | ||||
| GC61631 | Pactimibe | 189198-30-9 | >98.00% | |
Pactimibe (CS-505 free base) is a dual ACAT1/2 inhibitor with IC50s of 4.9 μM and 3.0 μM, respectively. | ||||
| GC61888 | Pactimibe sulfate | 608510-47-0 | >98.00% | |
Pactimibe sulfate (CS-505) is a dual ACAT1/2 inhibitor with IC50s of 4.9 μM and 3.0 μM, respectively. | ||||
| GC62428 | Ervogastat | 2186700-33-2 | >98.00% | |
| GC62744 | (Rac)-OSMI-1 | 2748153-92-4 | >96.00% | |
(Rac)-OSMI-1 is the racemate of OSMI-1. | ||||
| GC64687 | BMS-963272 | 1441057-15-3 | >99.00% | |
BMS-963272 is a potent, selective MGAT2 inhibitor (IC50 = 7.1 nM) for the treatment of metabolic disorders. | ||||
| GC65200 | Nevanimibe hydrochloride | 133825-81-7 | >98.00% | |
Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer. | ||||
| GC70245 | CP-113818 | 135025-12-6 | >99.00% | |
CP-113818 is a potent cholesterol acyltransferase (ACAT) inhibitor. | ||||
| GC70746 | OSMI-2 | 2260542-60-5 | >98.00% | |
OSMI-2 (Compound 1b) is a cell-permeable O-linked N-acetylglucosamine transferase (OGT) inhibitor. | ||||
| GC71495 | Lecimibide | 130804-35-2 | - | |
Lecimibide (DuP 128) is a potent and specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor for antihyperlipidemia research. | ||||
| GC73626 | PF-07202954 | 2639372-47-5 | >97.00% | |
PF-07202954 is a weakly basic DGAT2 inhibitor with an IC50 of 10 nM for human DGAT2. | ||||
| GC74100 | Eflucimibe | 202340-45-2 | >99.50% | |
Eflucimibe (F 12511) is a new acyl-coenzyme A cholesterol O-acyltransferase (ACAT) inhibitor. | ||||
| GC74105 | H2-003 | 1060438-30-3 | >99.00% | |
H2-003 is a selective human DGAT2 inhibitor that inhibits triglyceride (TG) biosynthesis. | ||||
| GC79554 | PF-06427878 | 1809064-23-0 | >98% | |
PF-06427878 is an orally active, selective liver-targeted diacylglycerol acyltransferase 2 ( DGAT2 ) inhibitor with IC 50 s of 99 nM and 202 nM for human and rat DGAT2, respectively. | ||||
| GC79555 | Ent-Calquiquelignan E | 1292294-31-5 | >98% | |
Ent-Calquiquelignan E (Compound 8) is a flavonoid lignan compound. | ||||
| GC79556 | SPT-IN-2 | 2035011-97-1 | >99.00% | |
SPT-IN-2 is an orally active serine palmitoyltransferase ( SPT ) inhibitor (with an IC 50 of 0.71 nM against human SPT2 ). | ||||
| GC79557 | ST1060 | 1402702-76-4 | >96.50% | |
ST1060 is a Ceramide synthase 2 ( CerS2 ) inhibitor. | ||||
| GC79707 | ST1072 | 1402703-50-7 | >98% | |
ST1072 is an inhibitor of CerS4 and CerS6. | ||||
| GC90472 | Cyano-myracrylamide | 2801702-34-9 | >98.00% | |
A zDHHC20 inhibitor | ||||