GLPBio

Dipeptidyl Peptidase

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Dipeptidyl Peptidase (DPP) is an antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation,signal transduction and apoptosis. DPP is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPP are proline-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPP plays a major role in glucose metabolism. DPP is responsible for the degradation of incretins such as GLP-1. Furthermore, DPP appears to work as a suppressor in the development of cancer and tumours. DPP plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others.

Products Related to Dipeptidyl Peptidase(55)

  • GC31444 structure
    GC31444Saikogenin A
    CAS: 5092-09-1
    Purity: >98.00%

    Saikogenin A, extracted from a Chinese herbal plant called Tsai-Fu, is a dipeptidyl peptidase-IV (DPP-IV) inhibitor.

  • GC31463 structure
    GC31463Gosogliptin (PF-00734200)
    CAS: 869490-23-3
    Purity: >98.50%

    Gosogliptin (PF-00734200) is a potent and selective inhibitor of dipeptidyl peptidase-IV (DPP-IV).

  • GC31467 structure
    GC31467Dutogliptin
    CAS: 852329-66-9
    Purity: >99.00%

    Dutogliptin (PHX-1149 free base) is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.

  • GC31472 structure
    GC31472Retagliptin Phosphate (SP 2086)
    CAS: 1256756-88-3
    Purity: >99.50%

    Retagliptin Phosphate (SP 2086) (SP2086 phosphate) is a selective, competitive and orally active dipeptidyl peptidase-4 (DPP-4) inhibitor.

  • GC31492 structure
    GC31492Vildagliptin dihydrate (LAF237 dihydrate)
    CAS: 2133364-01-7
    Purity: >98%

    Vildagliptin dihydrate (LAF237 dihydrate) (LAF237 dihydrate) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells.

  • GC31547 structure
    GC31547DPP-IV-IN-1
    CAS: 625110-37-4
    Purity: >98%

    DPP-IV-IN-1 is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV), a highly specific serine protease, with an IC50 of 4.6 nM.

  • GC32546 structure
    GC32546Prodipine hydrochloride
    CAS: 31314-39-3
    Purity: >98%

    Prodipine, a diphenyl-phosphonate derivative.

  • GC33769 structure
    GC33769Gemigliptin (LC15-0444)
    CAS: 911637-19-9
    Purity: >98%

    Gemigliptin (LC15-0444) (LC15-0444 ) is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC50 of 10.3 nM for human recombinant DPP-4.

  • GC33853 structure
    GC33853Talabostat (PT100)
    CAS: 149682-77-9
    Purity: >98%

    Talabostat (PT100) is an orally active and non-selective inhibitor of dipeptidyl peptidase IV (DPP-IV) ( IC 50 < 4 nM; K i = 0.18 nM) and the first clinical inhibitor of fibroblast activation protein (FAP) ( IC 50 = 560 nM), inhibiting DPP 8/9 ( IC 50 = 4/11 nM; K i = 1.5/0.76 nM), prolyl endopeptidase (QPP) (IC50= 310 nM), DPP2, and other DASH family enzymes.

  • GC37594 structure
    GC37594Saxagliptin hydrate
    CAS: 945667-22-1
    Purity: >99.00%

    Saxagliptin hydrate is a highly potent dipeptidyl peptidase-4 (DPP-4) inhibitor that regulates blood glucose by selectively inhibiting the DPP-4 enzyme, thereby elevating levels of endogenous glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).

  • GC37757 structure
    GC37757Teneligliptin hydrobromide hydrate
    CAS: 1572583-29-9
    Purity: >98%

    A DPP-4 inhibitor

  • GC39296 structure
    GC392961G244
    CAS: 847928-32-9
    Purity: >98.50%

    1G244 is a potent DPP8/9 inhibitor with IC50s of 12 nM and 84 nM, respectively. 1G244 does not inhibit DPPIV and DPPII. 1G244 induces apoptosis in multiple myeloma cells and has anti-myeloma effects.

  • GC44353 structure
    GC44353NDMC101
    CAS: 1308631-40-4
    Purity: >99.50%

    A salicylanilide derivative

  • GC44874 structure
    GC44874Saxagliptin (hydrochloride)
    CAS: 709031-78-7
    Purity: >98.00%

    Saxagliptin is a potent inhibitor of dipeptidyl peptidase 4 (DPP-4; Ki = 0.6 nM).

  • GC45436 structure
    GC45436Diprotin A
    CAS: 90614-48-5
    Purity: >99.50%

  • GC47751 structure
    GC47751Nateglinide-d5
    CAS: 1227666-13-8
    Purity: >99.00%

    An internal standard for the quantification of nateglinide

  • GC60613 structure
    GC60613Azaleatin
    CAS: 529-51-1
    Purity: >98%

    Azaleatin is an O-methylated flavonol isolated from Rhododendron species.

  • GC60828 structure
    GC60828Evogliptin tartrate
    CAS: 1222102-51-3
    Purity: >99.50%

    Evogliptin tartrate is a potent, orally bioavailable and selective dipeptidyl peptidase-4 (DPP-4) inhibitor, with antidiabetic activity.

  • GC62280 structure
    GC62280Teneligliptin D8
    CAS: 1391012-95-5
    Purity: >98%

    Teneligliptin D8 (MP-513 D8) a deuterium labeled Teneligliptin (MP-513).

  • GC63170 structure
    GC63170Retagliptin
    CAS: 1174122-54-3
    Purity: >98.50%

    Retagliptin (SP2086) is a selective, competitive and orally active dipeptidyl peptidase-4 (DPP-4) inhibitor.

  • GC63383 structure
    GC63383Sitagliptin-d4 phosphate
    CAS: 1432063-88-1
    Purity: >98%
  • GC66355 structure
    GC66355Linagliptin-d4
    CAS: 2140263-92-7
    Purity: >98%

    Linagliptin-d4 is deuterium labeled Linagliptin. Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM.

  • GC68890 structure
    GC68890Cofrogliptin
    CAS: 1844874-26-5
    Purity: >98.00%

    Cofrogliptin (HSK7653) (compound 2), a tetrahydrofuran derivative, is an effective oral DPP-4 inhibitor with long-lasting blood sugar-lowering effects. Cofrogliptin (compound 2) has great potential in the treatment of type 2 diabetes mellitus (T2DM).

  • GC69900 structure
    GC69900Sitagliptin fenilalanil
    CAS: 1339955-03-1
    Purity: >99.00%

    Sitagliptin phenylalanine is a dipeptidyl peptidase-4 (DPP-4) inhibitor.