Gamma Secretase
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Gamma secretase (γ-secretase), a member of the intramembrane cleaving protease (i-CLiP) family, is a promiscuous di-aspartyl protease that catalyzes the regulated intramembrane proteolysis (RIP), in which substrate proteins are cleaved within their membrane-spanning domain. A functional γ-secretase is a multi-protein complex consisting of the catalytic component, presenilin (PSEN), and three protein cofactors, including nicastrin (NCT), anterior-pharynx defective-1 (APH1) and PSEN enhancer-2 (PEN2). So far, 90 substrates of γ-secretase have been identified, which are type-I transmembrane proteins, except for glutamate receptor GluR3, polycystin-1 and glucosaminyltransferase (GnT-V), and appear to function as signaling proteins regulating a wide variety of cellular events, such as Notch signaling pathway.
Products Related to Gamma Secretase(42)
- GC33118Compound ECAS: 209986-17-4Purity: >98.00%
Compound E is a γ-secretase inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively.
- GC35535BMS-906024CAS: 1401066-79-2Purity: >98.00%
BMS-906024 is an orally active and selective γ-secretase (gamma secretase) inhibitor. BMS-906024 is a potent pan-Notch receptors inhibitor with IC50s of 1.6 nM, 0.7 nM, 3.4 nM, and 2.9 nM for Notch1, -2, -3, and -4 receptors, respectively. BMS-906024 demonstrates broad-spectrum antineoplastic activity.
- GC36107gamma-secretase modulator 1CAS: 1172637-87-4Purity: >98.00%
γ-secretase inhibitior-1 is a gamma-secretase modulator, γ-secretase inhibitior-1 is useful for Alzheimer's disease.
- GC36108gamma-secretase modulator 2CAS: 1093978-89-2Purity: >98.50%
gamma-secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's disease.
- GC36109gamma-secretase modulator 3CAS: 1431697-84-5Purity: >99.00%
gamma-secretase modulator 3 is a gamma-secretase modulator.
- GC36512LY-411575 isomer 1CAS: 209984-58-7Purity: >99.50%
LY-411575 isomer 1 is an isomer of LY411575, which is a potent γ-secretase inhibitor.
- GC38782gamma-secretase modulator 1 hydrochlorideCAS: 2741571-83-3Purity: >98.50%
gamma-secretase inhibitior-1 is a gamma-secretase modulator, γ-secretase inhibitior-1 is useful for Alzheimer's disease.
- GC50251PF 3084014 hydrobromideCAS: 1962925-29-6Purity: >95.00%
PF 3084014 hydrobromide is a highly potent and selective γ-secretase inhibitor belonging to the azacycle compound class, with an IC₅₀ of 1.2nM.
- GC63366FosciclopiroxCAS: 1380539-06-9Purity: >98%
Fosciclopirox suppresses growth of urothelial cancer by targeting the γ-secretase complex.
- GC63407PF-06648671CAS: 1587727-31-8Purity: >98.00%
PF-06648671?is a novel, brain‐penetrable, and orally active γ‐secretase modulator (GSM).
- GC67476(E/Z)-Sulindac sulfideCAS: 32004-67-4Purity: >98%
(E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM). (E/Z)-Sulindac sulfide selectively reduces Aβ42 production in favor of shorter Aβ species. (E/Z)-Sulindac sulfide can be used for researching Alzheimer's disease.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC33118 | Compound E | 209986-17-4 | >98.00% | |
Compound E is a γ-secretase inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively. | ||||
| GC35535 | BMS-906024 | 1401066-79-2 | >98.00% | |
BMS-906024 is an orally active and selective γ-secretase (gamma secretase) inhibitor. BMS-906024 is a potent pan-Notch receptors inhibitor with IC50s of 1.6 nM, 0.7 nM, 3.4 nM, and 2.9 nM for Notch1, -2, -3, and -4 receptors, respectively. BMS-906024 demonstrates broad-spectrum antineoplastic activity. | ||||
| GC35921 | E 2012 | 870843-42-8 | >98% | |
E 2012 is a potent gamma (γ) secretase modulator without affecting Notch processing. | ||||
| GC36107 | gamma-secretase modulator 1 | 1172637-87-4 | >98.00% | |
γ-secretase inhibitior-1 is a gamma-secretase modulator, γ-secretase inhibitior-1 is useful for Alzheimer's disease. | ||||
| GC36108 | gamma-secretase modulator 2 | 1093978-89-2 | >98.50% | |
gamma-secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's disease. | ||||
| GC36109 | gamma-secretase modulator 3 | 1431697-84-5 | >99.00% | |
gamma-secretase modulator 3 is a gamma-secretase modulator. | ||||
| GC36512 | LY-411575 isomer 1 | 209984-58-7 | >99.50% | |
LY-411575 isomer 1 is an isomer of LY411575, which is a potent γ-secretase inhibitor. | ||||
| GC36513 | LY-411575 isomer 2 | - | >99.50% | |
| GC36514 | LY-411575 isomer 3 | - | >99.00% | |
| GC38011 | γ-Secretase modulator 4 | 1420200-82-3 | >98% | |
| GC38782 | gamma-secretase modulator 1 hydrochloride | 2741571-83-3 | >98.50% | |
gamma-secretase inhibitior-1 is a gamma-secretase modulator, γ-secretase inhibitior-1 is useful for Alzheimer's disease. | ||||
| GC50251 | PF 3084014 hydrobromide | 1962925-29-6 | >95.00% | |
PF 3084014 hydrobromide is a highly potent and selective γ-secretase inhibitor belonging to the azacycle compound class, with an IC₅₀ of 1.2nM. | ||||
| GC62859 | Aβ42-IN-2 | 1914989-80-2 | >98.00% | |
Aβ42-IN-2 is a γ-secretase modulator extracted from patent WO2016070107, compound example 36. | ||||
| GC62998 | GSM-1 | 884600-68-4 | >98.00% | |
GSM-1 is a potent γ-secretase modulator. | ||||
| GC63366 | Fosciclopirox | 1380539-06-9 | >98% | |
Fosciclopirox suppresses growth of urothelial cancer by targeting the γ-secretase complex. | ||||
| GC63407 | PF-06648671 | 1587727-31-8 | >98.00% | |
PF-06648671?is a novel, brain‐penetrable, and orally active γ‐secretase modulator (GSM). | ||||
| GC67476 | (E/Z)-Sulindac sulfide | 32004-67-4 | >98% | |
(E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM). (E/Z)-Sulindac sulfide selectively reduces Aβ42 production in favor of shorter Aβ species. (E/Z)-Sulindac sulfide can be used for researching Alzheimer's disease. | ||||
| GC16434 | TC-E 5006 | 1257395-14-4 | >98% | |
γ-secretase modulator | ||||