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Home >> Signaling Pathways >> Proteases >> Gamma Secretase

Gamma Secretase

Gamma secretase (γ-secretase), a member of the intramembrane cleaving protease (i-CLiP) family, is a promiscuous di-aspartyl protease that catalyzes the regulated intramembrane proteolysis (RIP), in which substrate proteins are cleaved within their membrane-spanning domain. A functional γ-secretase is a multi-protein complex consisting of the catalytic component, presenilin (PSEN), and three protein cofactors, including nicastrin (NCT), anterior-pharynx defective-1 (APH1) and PSEN enhancer-2 (PEN2). So far, 90 substrates of γ-secretase have been identified, which are type-I transmembrane proteins, except for glutamate receptor GluR3, polycystin-1 and glucosaminyltransferase (GnT-V), and appear to function as signaling proteins regulating a wide variety of cellular events, such as Notch signaling pathway.

Products for  Gamma Secretase

  1. Cat.No. Product Name Information
  2. GC38011 γ-Secretase modulator 4 γ-Secretase modulator 4 Chemical Structure
  3. GC67476 (E/Z)-Sulindac sulfide (E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM). (E/Z)-Sulindac sulfide selectively reduces Aβ42 production in favor of shorter Aβ species. (E/Z)-Sulindac sulfide can be used for researching Alzheimer's disease. (E/Z)-Sulindac sulfide Chemical Structure
  4. GC62859 Aβ42-IN-2 Aβ42-IN-2 is a γ-secretase modulator extracted from patent WO2016070107, compound example 36. Aβ42-IN-2 Chemical Structure
  5. GC12659 Begacestat An inhibitor of γ-secretase Begacestat Chemical Structure
  6. GC13099 BMS 299897 A γ-secretase inhibitor BMS 299897 Chemical Structure
  7. GC31012 BMS 433796 BMS 433796 is a γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer's disease. BMS 433796 Chemical Structure
  8. GC13673 BMS-708163 (Avagacestat) A potent inhibitor of γ-secretase BMS-708163 (Avagacestat) Chemical Structure
  9. GC35535 BMS-906024 BMS-906024 is an orally active and selective γ-secretase (gamma secretase) inhibitor. BMS-906024 is a potent pan-Notch receptors inhibitor with IC50s of 1.6 nM, 0.7 nM, 3.4 nM, and 2.9 nM for Notch1, -2, -3, and -4 receptors, respectively. BMS-906024 demonstrates broad-spectrum antineoplastic activity. BMS-906024 Chemical Structure
  10. GC33118 Compound E Compound E is a γ-secretase inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively. Compound E Chemical Structure
  11. GC15645 Compound W A Notch1 signaling modulator Compound W Chemical Structure
  12. GC12942 DAPT (GSI-IX)

    Inhibitor of γ-secretase

     DAPT (GSI-IX) Chemical Structure
  13. GC35921 E 2012 E 2012 is a potent gamma (γ) secretase modulator without affecting Notch processing. E 2012 Chemical Structure
  14. GC30427 ELN 318463 racemate ELN 318463 racemate is the racemate of ELN318463. ELN 318463 racemate Chemical Structure
  15. GC10064 Flurizan A COX-inactive enantiomer of flurbiprofen Flurizan Chemical Structure
  16. GC63366 Fosciclopirox Fosciclopirox suppresses growth of urothelial cancer by targeting the γ-secretase complex. Fosciclopirox Chemical Structure
  17. GC36107 gamma-secretase modulator 1 γ-secretase inhibitior-1 is a gamma-secretase modulator, γ-secretase inhibitior-1 is useful for Alzheimer's disease. gamma-secretase modulator 1 Chemical Structure
  18. GC38782 gamma-secretase modulator 1 hydrochloride gamma-secretase inhibitior-1 is a gamma-secretase modulator, γ-secretase inhibitior-1 is useful for Alzheimer's disease. gamma-secretase modulator 1 hydrochloride Chemical Structure
  19. GC36108 gamma-secretase modulator 2 gamma-secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's disease. gamma-secretase modulator 2 Chemical Structure
  20. GC36109 gamma-secretase modulator 3 gamma-secretase modulator 3 is a gamma-secretase modulator. gamma-secretase modulator 3 Chemical Structure
  21. GC62998 GSM-1 GSM-1 is a potent γ-secretase modulator. GSM-1 Chemical Structure
  22. GC30954 Itanapraced (CHF5074) Itanapraced (CHF5074) (CHF5074) is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively. Itanapraced (CHF5074) Chemical Structure
  23. GC13619 JLK 6 A protease inhibitor JLK 6 Chemical Structure
  24. GC15364 L-685,458 A γ-secretase inhibitor L-685,458 Chemical Structure
  25. GC12191 LY-411575 A γ-secretase inhibitor LY-411575 Chemical Structure
  26. GC36512 LY-411575 isomer 1 LY-411575 isomer 1 is an isomer of LY411575, which is a potent γ-secretase inhibitor. LY-411575 isomer 1 Chemical Structure
  27. GC36513 LY-411575 isomer 2 LY-411575 isomer 2 Chemical Structure
  28. GC36514 LY-411575 isomer 3 LY-411575 isomer 3 Chemical Structure
  29. GC17791 LY2811376 A BACE1 inhibitor LY2811376 Chemical Structure
  30. GC12653 LY3039478 A Notch inhibitor LY3039478 Chemical Structure
  31. GC15899 MK-0752 A potent inhibitor of γ-secretase MK-0752 Chemical Structure
  32. GC16431 MRK 560 A potent inhibitor of γ-secretase MRK 560 Chemical Structure
  33. GC30887 NGP555 A γ-secretase modulator NGP555 Chemical Structure
  34. GC50251 PF 3084014 hydrobromide PF 3084014 hydrobromide (PF-3084014 dihydrobromide) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC50 of 6.2 nM. Inhibition of Notch signaling by PF 3084014 hydrobromide while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers. PF 3084014 hydrobromide Chemical Structure
  35. GC10998 PF-03084014

    γ-secretase inhibitor

     PF-03084014 Chemical Structure
  36. GC63407 PF-06648671 PF-06648671?is a novel, brain‐penetrable, and orally active γ‐secretase modulator (GSM). PF-06648671 Chemical Structure
  37. GC19290 PF-3084014 PF-3084014 (PF-3084014) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC50 of 6.2 nM. Inhibition of Notch signaling by PF-3084014 while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers. PF-3084014 Chemical Structure
  38. GC16197 RO4929097

    An inhibitor of γ-secretase

     RO4929097 Chemical Structure
  39. GC12096 Semagacestat (LY450139) A pan γ-secretase inhibitor Semagacestat (LY450139) Chemical Structure
  40. GC15059 Sulindac sulfide

    COX inhibitor

     Sulindac sulfide Chemical Structure
  41. GC16434 TC-E 5006 γ-secretase modulator TC-E 5006 Chemical Structure
  42. GC17671 YO-01027 (Dibenzazepine, DBZ) An inhibitor of γ-secretase YO-01027 (Dibenzazepine, DBZ) Chemical Structure
  43. GC15896 Z-Ile-Leu-aldehyde potent gamma-Secretase inhibitor Z-Ile-Leu-aldehyde Chemical Structure

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