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Gamma Secretase

Gamma secretase (γ-secretase), a member of the intramembrane cleaving protease (i-CLiP) family, is a promiscuous di-aspartyl protease that catalyzes the regulated intramembrane proteolysis (RIP), in which substrate proteins are cleaved within their membrane-spanning domain. A functional γ-secretase is a multi-protein complex consisting of the catalytic component, presenilin (PSEN), and three protein cofactors, including nicastrin (NCT), anterior-pharynx defective-1 (APH1) and PSEN enhancer-2 (PEN2). So far, 90 substrates of γ-secretase have been identified, which are type-I transmembrane proteins, except for glutamate receptor GluR3, polycystin-1 and glucosaminyltransferase (GnT-V), and appear to function as signaling proteins regulating a wide variety of cellular events, such as Notch signaling pathway.

  1. Cat.No. Product Name Information
  2. GC12659 Begacestat γ-secretase inhibitor
  3. GC13099 BMS 299897 γ--secretase inhibitor, potent and orally active
  4. GC31012 BMS 433796
  5. GC13673 BMS-708163 (Avagacestat) γ-secretase inhibitor
  6. GC35535 BMS-906024
  7. GC33118 Compound E (Compound E (secretase inhibitor) DuPont E)
  8. GC15645 Compound W γ-secretase inhibitor
  9. GC12942 DAPT (GSI-IX) γ-secretase inhibitor,potent and specific
  10. GC35921 E 2012
  11. GC30427 ELN 318463 racemate
  12. GC10064 Flurizan

    NSAID,inhibits γ-secretase activity

  13. GC36107 gamma-secretase modulator 1
  14. GC38782 gamma-secretase modulator 1 hydrochloride
  15. GC36108 gamma-secretase modulator 2
  16. GC36109 gamma-secretase modulator 3
  17. GC30954 Itanapraced (CHF5074)
  18. GC13619 JLK 6 γ-secretase inhibitor
  19. GC15364 L-685,458 γ-secretase inhibitor
  20. GC12191 LY-411575 Gamma secretase inhibitor
  21. GC36512 LY-411575 isomer 1

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