Smoothened

Smoothened is a G protein-coupled receptor of the hedgehog signaling pathway.

Products Related to Smoothened(36)

GC37580 SAG hydrochloride
CAS: 2095432-58-7
Purity: >99.50%
SAG hydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG hydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine inhibition of Smo.
GC50135 SAG 21k
CAS: 946002-48-8
Purity: >98.00%
SAG 21k is a potent and orally bioavailable Hedgehog signaling activator with an EC 50 value of 0.4nM.
GC50203 IHR-Cy3
Purity: >98%
Potent fluorescent Smo antagonist
GC50486 Dynarrestin
CAS: 2222768-84-3
Purity: >99.50%
Inhibitor of Hedgehog (Hh) signaling; inhibits cytoplasmic dynein
GC50685 Dynapyrazole A
CAS: 2226517-75-3
Purity: >98.00%
GC62258 SAG-d3
Purity: >98.50%
SAG-d3 is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM).
GC63336 MRT-81
CAS: 1263132-08-6
Purity: >98%
MRT-81 is a potent antagonist of human and rodent smoothened (Smo) receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer.
GC63863 MRT-83 hydrochloride
CAS: 1359944-60-7
Purity: >99.00%
MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease.
GC64419 MRT-14
CAS: 1263131-83-4
Purity: >98.00%
MRT-14 is a potent antagonist of Smo. Smo is the major component involved in signal transduction of the Hedgehog (Hh) morphogens. MRT-14 has the potential for the research of several types of cancers linked to abnormal Hh signaling.
GC73310 SMO-IN-2
CAS: 1822355-27-0
Purity: >98.00%
SMO-IN-2 (compound 1) is a potent smoothened (SMO) inhibitor with an IC50 value of 123.4 nM for hedgehog (Hh) signaling pathway.
GC81339 Taladegib hydrochloride
CAS: 1258861-21-0
Purity: >97.00%
Taladegib (LY2940680) hydrochloride is a Smoothened ( SMO ) antagonist.
GC13655 LDE225 (NVP-LDE225,Erismodegib)
CAS: 956697-53-3
Purity: >99.50%
LDE225 (NVP-LDE225,Erismodegib) (Erismodegib) is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively.

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC37580	SAG hydrochloride	2095432-58-7	>99.50%
GC37580	SAG hydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG hydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine inhibition of Smo.
GC50135	SAG 21k	946002-48-8	>98.00%
GC50135	SAG 21k is a potent and orally bioavailable Hedgehog signaling activator with an EC 50 value of 0.4nM.
GC50203	IHR-Cy3	-	>98%
GC50203	Potent fluorescent Smo antagonist
GC50486	Dynarrestin	2222768-84-3	>99.50%
GC50486	Inhibitor of Hedgehog (Hh) signaling; inhibits cytoplasmic dynein
GC50685	Dynapyrazole A	2226517-75-3	>98.00%
GC62258	SAG-d3	-	>98.50%
GC62258	SAG-d3 is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM).
GC63336	MRT-81	1263132-08-6	>98%
GC63336	MRT-81 is a potent antagonist of human and rodent smoothened (Smo) receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer.
GC63863	MRT-83 hydrochloride	1359944-60-7	>99.00%
GC63863	MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease.
GC64419	MRT-14	1263131-83-4	>98.00%
GC64419	MRT-14 is a potent antagonist of Smo. Smo is the major component involved in signal transduction of the Hedgehog (Hh) morphogens. MRT-14 has the potential for the research of several types of cancers linked to abnormal Hh signaling.
GC73310	SMO-IN-2	1822355-27-0	>98.00%
GC73310	SMO-IN-2 (compound 1) is a potent smoothened (SMO) inhibitor with an IC50 value of 123.4 nM for hedgehog (Hh) signaling pathway.
GC81339	Taladegib hydrochloride	1258861-21-0	>97.00%
GC81339	Taladegib (LY2940680) hydrochloride is a Smoothened ( SMO ) antagonist.
GC13655	LDE225 (NVP-LDE225,Erismodegib)	956697-53-3	>99.50%
GC13655	LDE225 (NVP-LDE225,Erismodegib) (Erismodegib) is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively.